Detailed information NTG0668110

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: MP387_RS05415
• Genome accession: NZ_CP094226
• Coordinates: 1109301..1109975 (-)
• Length: 224 a.a.
• NCBI ID: WP_000590630.1
• Uniprot ID: A0A4V0BT06
• Organism: Streptococcus oralis strain 1648
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1104301..1114975

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MP387_RS05390 (MP387_05390)	-	1104437..1105366 (-)	930	WP_000411181.1	peptidase U32 family protein	-
MP387_RS05395 (MP387_05395)	-	1105491..1106171 (-)	681	WP_242745593.1	ABC transporter ATP-binding protein	-
MP387_RS05400 (MP387_05400)	-	1106185..1107240 (-)	1056	WP_242745600.1	ABC transporter permease	-
MP387_RS05405 (MP387_05405)	-	1107626..1107910 (+)	285	WP_084918530.1	DUF3270 domain-containing protein	-
MP387_RS05410 (MP387_05410)	ciaH	1107974..1109311 (-)	1338	WP_242745602.1	HAMP domain-containing sensor histidine kinase	Regulator
MP387_RS05415 (MP387_05415)	ciaR	1109301..1109975 (-)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
MP387_RS05420 (MP387_05420)	-	1110085..1112631 (-)	2547	WP_242745604.1	M1 family metallopeptidase	-
MP387_RS05425 (MP387_05425)	-	1112753..1113193 (-)	441	WP_242745606.1	ASCH domain-containing protein	-
MP387_RS05430 (MP387_05430)	-	1113190..1113687 (-)	498	WP_242745608.1	NUDIX hydrolase	-
MP387_RS05435 (MP387_05435)	-	1113727..1114332 (-)	606	Protein_1024	DUF6707 family protein	-
MP387_RS05445 (MP387_05445)	-	1114392..1114943 (-)	552	WP_242745613.1	hypothetical protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25479.29 Da
• Isoelectric Point: 4.2660

>NTDB_id=668110 MP387_RS05415 WP_000590630.1 1109301..1109975(-) (ciaR) [Streptococcus oralis strain 1648]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=668110 MP387_RS05415 WP_000590630.1 1109301..1109975(-) (ciaR) [Streptococcus oralis strain 1648]
ATGATAAAAATCTTATTAGTCGAAGATGACCTAGGCCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGACTTGATTTTGCTTGACCTGATGT
TGCCGGAAAAAAATGGTTTCCAAGTCTTGAAAGAATTGCGCGAAAAAGGAATTACCACACCAGTCCTTATCATGACCGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCAGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAACGAAAACACCTTGACCTATGGAGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAGGTGGAAGATACTCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTTATTCTTCCTAAGACGCAAATTTTTGACCGTCTATGGGGGTTTGATAGCGATACGACGAT
TTCTGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A4V0BT06

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	97.768	100	0.978
ciaR	Streptococcus pneumoniae D39	97.768	100	0.978
ciaR	Streptococcus pneumoniae R6	97.768	100	0.978
ciaR	Streptococcus pneumoniae Rx1	97.768	100	0.978
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366