Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   MP387_RS05410 Genome accession   NZ_CP094226
Coordinates   1107974..1109311 (-) Length   445 a.a.
NCBI ID   WP_242745602.1    Uniprot ID   -
Organism   Streptococcus oralis strain 1648     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1102974..1114311
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MP387_RS05385 (MP387_05385) rpiA 1103648..1104331 (-) 684 WP_242745586.1 ribose-5-phosphate isomerase RpiA -
  MP387_RS05390 (MP387_05390) - 1104437..1105366 (-) 930 WP_000411181.1 peptidase U32 family protein -
  MP387_RS05395 (MP387_05395) - 1105491..1106171 (-) 681 WP_242745593.1 ABC transporter ATP-binding protein -
  MP387_RS05400 (MP387_05400) - 1106185..1107240 (-) 1056 WP_242745600.1 ABC transporter permease -
  MP387_RS05405 (MP387_05405) - 1107626..1107910 (+) 285 WP_084918530.1 DUF3270 domain-containing protein -
  MP387_RS05410 (MP387_05410) ciaH 1107974..1109311 (-) 1338 WP_242745602.1 HAMP domain-containing sensor histidine kinase Regulator
  MP387_RS05415 (MP387_05415) ciaR 1109301..1109975 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  MP387_RS05420 (MP387_05420) - 1110085..1112631 (-) 2547 WP_242745604.1 M1 family metallopeptidase -
  MP387_RS05425 (MP387_05425) - 1112753..1113193 (-) 441 WP_242745606.1 ASCH domain-containing protein -
  MP387_RS05430 (MP387_05430) - 1113190..1113687 (-) 498 WP_242745608.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50838.66 Da        Isoelectric Point: 9.7636

>NTDB_id=668109 MP387_RS05410 WP_242745602.1 1107974..1109311(-) (ciaH) [Streptococcus oralis strain 1648]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSILYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADANKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSTVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKPFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPVIAEVSPQFFKTTFANYELIASENDRVFNYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISATDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=668109 MP387_RS05410 WP_242745602.1 1107974..1109311(-) (ciaH) [Streptococcus oralis strain 1648]
ATGTTCAATAAACTAAAAAAAACATGGTATGCAGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACACTGAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGATTCTCTACACTTCTGTAGATGAAAAACTCCAAGCCC
TTAGTAGCAGTCCCCAAGCTGTCATCCAGTTAGCCCTGAATCGGGCAACTGAAGAGGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAACAAGGCTGAAATCAAACCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGTTTTTTAGGTTTGGACAAGATCAAGCTGGACAAAAAGGAGTTGAATCACATTCGCCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTATCGGATGATTTTGATGGAAACAAATTCGTCCACTGTTTCAAGCAAT
GTCAAATATGCGGCGGTTTTAATCAATACCAGCCAGCTCGAGCAAATCAGCCAAAATCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTACTTGGCACGCGTCAGTGTCAAACCCTTGCTGGAAAGCA
TGCAAAAGCAGAAGCCCTTTGTTGAAAATGCGAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTGGAA
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATCGCTTCCAGTCTTGAAGAAGTTCGCAACAT
GCGCTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGCGATGATGGAATCAAACCAGTAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACGACCTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGAGTTTTTAACTACGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTACTCCTAAAACAGCTCATGACCATTTTATTTGACAATGCCATCAAGTATACCGA
AGAAGATGGGAAAATTGAGTTCGTAGTTCATGCTACAGATCGTCACCTCTATCTAACAGTAACGGATAACGGAATTGGAA
TCTCAGCTACTGACAAGAAGAAAATCTTTGACCGTTTTTATCGTGTAGACAAGGCAAGAACTCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCCTTGGCCAAGCAGATCGTAGATGCCTTACGAGGAACGATTAGCGTAAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAAATCGCTATTCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(220-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.296

99.551

0.829
  ciaH Streptococcus pneumoniae D39

83.296

99.551

0.829
  ciaH Streptococcus pneumoniae R6

83.296

99.551

0.829
  ciaH Streptococcus pneumoniae TIGR4

83.296

99.551

0.829
  ciaH Streptococcus mutans UA159

54.338

98.427

0.535

Multiple sequence alignment