Detailed information NTG0066197

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SRT_RS10255
• Genome accession: NZ_AP014612
• Coordinates: 2095659..2096834 (+)
• Length: 391 a.a.
• NCBI ID: WP_128833990.1
• Uniprot ID: A0A1L7LMI0
• Organism: Streptococcus troglodytae strain TKU 31
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2090659..2101834

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SRT_RS10235	-	2092753..2093706 (+)	954	WP_128832720.1	DDE-type integrase/transposase/recombinase	-
SRT_RS10245 (SRT_20790)	-	2093937..2094599 (-)	663	WP_128833989.1	YoaK family protein	-
SRT_RS10250 (SRT_20800)	rlmH	2094942..2095421 (-)	480	WP_128834079.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SRT_RS10255 (SRT_20810)	htrA	2095659..2096834 (+)	1176	WP_128833990.1	S1C family serine protease	Regulator
SRT_RS10260 (SRT_20820)	spo0J	2096903..2097673 (+)	771	WP_161940058.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 391 a.a.
• Molecular weight: 41772.90 Da
• Isoelectric Point: 7.1962

>NTDB_id=66197 SRT_RS10255 WP_128833990.1 2095659..2096834(+) (htrA) [Streptococcus troglodytae strain TKU 31]
MVYTFFSYFLTFILGVISTLTFNWITGNKSFSNNGKTTVSNVIYDTKSNTTKAVKNVKNTVVSVINYQKTDNSYYNYDSG
SQEKNKSEDGLGVYGEGSGVIYKKDGDSAYLVTNNHVVKDAEKLEIMMANGKKVVGKLVGSDTYSDLAVIKISSKYVTTV
AEFANSDKIKVGEPAIAIGSPLGSDYANSVTEGIVSSLSRTVTSQNENGETISTNAIQTDAAINPGNSGGALINIKGQVI
GINSSKIASSNNSNSGVAVEGMGFAIPSNDVVSIINQLEENGEVVRPALGISMANLSEASTSGRDTLKIPSDVTSGIVVL
STQSGMPADGKLKKYDVITEIDGKKVASISDLQSILYKHKKGDKIKLTFYREKDKQTVEIQLTKTSQDLNN

Nucleotide

• Length: 1176 bp

>NTDB_id=66197 SRT_RS10255 WP_128833990.1 2095659..2096834(+) (htrA) [Streptococcus troglodytae strain TKU 31]
ATGGTTTATACCTTTTTTAGTTATTTTTTAACTTTTATTTTAGGAGTTATATCAACACTTACCTTTAATTGGATAACTGG
TAACAAATCGTTTTCTAACAATGGAAAAACAACTGTTAGTAATGTCATTTATGATACCAAATCCAACACTACCAAAGCTG
TCAAAAATGTCAAAAATACAGTTGTATCTGTCATCAATTATCAAAAAACAGATAATAGTTATTACAATTATGACAGCGGT
TCTCAAGAAAAAAATAAATCAGAGGATGGTCTAGGGGTCTACGGTGAAGGTTCTGGCGTTATCTACAAAAAAGATGGTGA
TAGTGCTTATTTAGTCACAAATAATCATGTCGTTAAAGATGCAGAAAAATTAGAAATCATGATGGCTAATGGTAAAAAAG
TTGTGGGTAAATTAGTAGGTTCTGATACTTATTCTGATCTGGCTGTTATTAAAATTTCTTCTAAGTATGTTACGACAGTT
GCTGAATTTGCTAATTCAGATAAAATAAAAGTTGGAGAACCAGCAATCGCTATTGGTAGCCCTTTAGGCAGTGATTATGC
TAATTCTGTAACAGAAGGAATTGTTTCAAGTCTCAGTCGTACAGTAACTTCACAAAATGAAAATGGCGAAACAATTTCAA
CTAATGCTATTCAAACAGACGCAGCTATTAACCCTGGTAATTCTGGTGGCGCTTTAATCAATATCAAGGGACAAGTTATT
GGTATCAATTCAAGTAAAATTGCATCAAGTAATAACTCAAATAGTGGCGTTGCTGTTGAAGGAATGGGCTTTGCAATTCC
TTCAAACGATGTTGTCTCTATTATTAATCAATTAGAAGAAAATGGTGAAGTTGTTAGACCCGCTCTTGGTATTTCAATGG
CTAATCTTAGTGAAGCTTCAACAAGTGGAAGAGATACTTTAAAAATACCAAGTGATGTCACAAGTGGTATTGTCGTTCTT
TCAACACAAAGTGGTATGCCAGCAGATGGGAAGCTGAAGAAATATGACGTCATTACAGAAATTGATGGAAAGAAAGTAGC
TTCTATCAGCGATCTTCAAAGTATTCTTTACAAACACAAAAAAGGAGATAAAATTAAACTCACTTTCTATCGCGAAAAAG
ATAAACAAACAGTTGAGATCCAATTAACTAAAACAAGTCAAGATTTGAATAACTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (97-242)

• Peptidase family M50 (Peptidase_M50) (231-387)

• PDZ domain (PDZ_2) (287-382)

3D structure

• AlphaFold DB: A0A1L7LMI0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	98.966	98.977	0.98
htrA	Streptococcus gordonii str. Challis substr. CH1	56.555	99.488	0.563
htrA	Streptococcus mitis NCTC 12261	55.352	97.954	0.542
htrA	Streptococcus pneumoniae Rx1	57.79	90.281	0.522
htrA	Streptococcus pneumoniae D39	57.79	90.281	0.522
htrA	Streptococcus pneumoniae R6	57.79	90.281	0.522
htrA	Streptococcus pneumoniae TIGR4	57.79	90.281	0.522