Detailed information NTG0066148

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SRT_RS00405
• Genome accession: NZ_AP014612
• Coordinates: 67250..68164 (+)
• Length: 304 a.a.
• NCBI ID: WP_128832666.1
• Uniprot ID: A0A1L7LGK5
• Organism: Streptococcus troglodytae strain TKU 31
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 62250..73164

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SRT_RS00380 (SRT_00610)	-	62833..63522 (+)	690	WP_128832661.1	aspartate/glutamate racemase family protein	-
SRT_RS00385 (SRT_00620)	-	63533..63937 (+)	405	WP_128832662.1	SRPBCC family protein	-
SRT_RS00390 (SRT_00630)	-	63973..64842 (+)	870	WP_128832663.1	hypothetical protein	-
SRT_RS00395 (SRT_00640)	purB	64859..66157 (+)	1299	WP_128832664.1	adenylosuccinate lyase	-
SRT_RS00400 (SRT_00650)	-	66206..66862 (+)	657	WP_128832665.1	DNA alkylation repair protein	-
SRT_RS00405 (SRT_00660)	comR	67250..68164 (+)	915	WP_128832666.1	helix-turn-helix domain-containing protein	Regulator
SRT_RS00410	-	68622..70462 (-)	1841	Protein_61	carbohydrate-binding domain-containing protein	-
SRT_RS00415 (SRT_00690)	ruvB	70869..71864 (+)	996	WP_128832667.1	Holliday junction branch migration DNA helicase RuvB	-
SRT_RS00420 (SRT_00700)	-	71902..72327 (+)	426	WP_128832668.1	low molecular weight protein-tyrosine-phosphatase	-
SRT_RS00425 (SRT_00710)	-	72392..72775 (+)	384	WP_128832669.1	hypothetical protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35304.42 Da
• Isoelectric Point: 4.9067

>NTDB_id=66148 SRT_RS00405 WP_128832666.1 67250..68164(+) (comR) [Streptococcus troglodytae strain TKU 31]
MLKDFGKKIKSLRLEKGLTKEAVCRDESQLSIRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSKKYNQLLETLLKQVHCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNEIMA
RTYDFQKKPIVNLLTWKHYLFVEKDYAQAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=66148 SRT_RS00405 WP_128832666.1 67250..68164(+) (comR) [Streptococcus troglodytae strain TKU 31]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAGGCTGTCTGCCGTGATGA
ATCGCAGTTGTCAATACGGCAGCTGACTAGAATTGAATCGGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGCCGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTCGAGTTACCCAGTCGTTATAAAGAACTAAAA
TATTTATTATTACGAACGCCAACCTATGGCGACCAGCAAAGATTAGCCGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGTTTACAATCGAAACTAGATATTCATTTTAGTG
ATAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGCTTGGATTCAGCTATTTTTGATTCAAAAAAATATAA
TCAATTATTGGAAACATTGCTTAAGCAGGTACATTGTCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATGAAATCATGGCT
AGAACTTATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAACACTATTTGTTTGTTGAAAAAGATTATGC
GCAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (9-64)

3D structure

• AlphaFold DB: A0A1L7LGK5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	97.039	100	0.97
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.778	94.737	0.5
comR	Streptococcus pyogenes MGAS315	47.157	98.355	0.464
comR	Streptococcus pyogenes MGAS8232	46.358	99.342	0.461
comR	Streptococcus suis P1/7	42.809	98.355	0.421
comR	Streptococcus suis 05ZYH33	42.809	98.355	0.421
comR	Streptococcus suis D9	37	98.684	0.365