Detailed information NTG0066072

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: M3B_RS00260
• Genome accession: NZ_AP014596
• Coordinates: 47468..48379 (+)
• Length: 303 a.a.
• NCBI ID: WP_011054099.1
• Uniprot ID: A0A5S4TJF2
• Organism: Streptococcus pyogenes strain M3-b
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42468..53379

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M3B_RS00240 (M3B_0049)	purE	42764..43255 (+)	492	WP_030127619.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
M3B_RS00245 (M3B_0050)	purK	43242..44315 (+)	1074	WP_032461293.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
M3B_RS00250 (M3B_0051)	-	44336..45676 (+)	1341	WP_002986685.1	hypothetical protein	-
M3B_RS00255 (M3B_0053)	purB	46045..47337 (+)	1293	WP_011054098.1	adenylosuccinate lyase	-
M3B_RS00260 (M3B_0054)	comR	47468..48379 (+)	912	WP_011054099.1	helix-turn-helix domain-containing protein	Regulator
M3B_RS10135	comS	48470..48568 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
M3B_RS00265 (M3B_0055)	ruvB	48599..49597 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
M3B_RS00270 (M3B_0056)	-	49735..50172 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
M3B_RS00275	-	50195..50596 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
M3B_RS00280 (M3B_0058)	-	50593..52368 (+)	1776	WP_011054101.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35896.55 Da
• Isoelectric Point: 4.9324

>NTDB_id=66072 M3B_RS00260 WP_011054099.1 47468..48379(+) (comR) [Streptococcus pyogenes strain M3-b]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGHLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=66072 M3B_RS00260 WP_011054099.1 47468..48379(+) (comR) [Streptococcus pyogenes strain M3-b]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCATCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

3D structure

• AlphaFold DB: A0A5S4TJF2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	100	100	1
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366