Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SMUNUM_RS05315 Genome accession   NZ_AP014571
Coordinates   1075798..1076472 (-) Length   224 a.a.
NCBI ID   WP_002264509.1    Uniprot ID   -
Organism   Streptococcus mutans LP13     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1070798..1081472
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNUM_RS05290 (SMNUM_0998) - 1071105..1072382 (-) 1278 WP_002297051.1 pyrimidine-nucleoside phosphorylase -
  SMUNUM_RS05295 (SMNUM_0999) - 1072491..1073087 (-) 597 WP_002268746.1 class I SAM-dependent methyltransferase -
  SMUNUM_RS05300 (SMNUM_1000) coaA 1073183..1074103 (+) 921 WP_002262217.1 type I pantothenate kinase -
  SMUNUM_RS05305 (SMNUM_1001) rpsT 1074157..1074411 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUNUM_RS05310 (SMNUM_1002) ciaH 1074501..1075808 (-) 1308 WP_002262215.1 three-component system sensor histidine kinase CiaH Regulator
  SMUNUM_RS05315 (SMNUM_1003) ciaR 1075798..1076472 (-) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  SMUNUM_RS05320 (SMNUM_1004) ciaX 1076523..1076786 (-) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUNUM_RS05325 (SMNUM_1005) - 1077187..1079736 (-) 2550 WP_002269276.1 M1 family metallopeptidase -
  SMUNUM_RS05330 (SMNUM_1006) phoU 1079777..1080430 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  SMUNUM_RS05335 (SMNUM_1007) pstB 1080462..1081220 (-) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25417.19 Da        Isoelectric Point: 4.3777

>NTDB_id=65977 SMUNUM_RS05315 WP_002264509.1 1075798..1076472(-) (ciaR) [Streptococcus mutans LP13]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=65977 SMUNUM_RS05315 WP_002264509.1 1075798..1076472(-) (ciaR) [Streptococcus mutans LP13]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment