Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SMUNUM_RS05310 Genome accession   NZ_AP014571
Coordinates   1074501..1075808 (-) Length   435 a.a.
NCBI ID   WP_002262215.1    Uniprot ID   -
Organism   Streptococcus mutans LP13     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1069501..1080808
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNUM_RS05280 (SMNUM_0996) - 1070048..1070434 (-) 387 WP_002264513.1 cytidine deaminase -
  SMUNUM_RS05285 (SMNUM_0997) deoC 1070424..1071086 (-) 663 WP_002268748.1 deoxyribose-phosphate aldolase -
  SMUNUM_RS05290 (SMNUM_0998) - 1071105..1072382 (-) 1278 WP_002297051.1 pyrimidine-nucleoside phosphorylase -
  SMUNUM_RS05295 (SMNUM_0999) - 1072491..1073087 (-) 597 WP_002268746.1 class I SAM-dependent methyltransferase -
  SMUNUM_RS05300 (SMNUM_1000) coaA 1073183..1074103 (+) 921 WP_002262217.1 type I pantothenate kinase -
  SMUNUM_RS05305 (SMNUM_1001) rpsT 1074157..1074411 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUNUM_RS05310 (SMNUM_1002) ciaH 1074501..1075808 (-) 1308 WP_002262215.1 three-component system sensor histidine kinase CiaH Regulator
  SMUNUM_RS05315 (SMNUM_1003) ciaR 1075798..1076472 (-) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  SMUNUM_RS05320 (SMNUM_1004) ciaX 1076523..1076786 (-) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUNUM_RS05325 (SMNUM_1005) - 1077187..1079736 (-) 2550 WP_002269276.1 M1 family metallopeptidase -
  SMUNUM_RS05330 (SMNUM_1006) phoU 1079777..1080430 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49868.35 Da        Isoelectric Point: 9.7262

>NTDB_id=65976 SMUNUM_RS05310 WP_002262215.1 1074501..1075808(-) (ciaH) [Streptococcus mutans LP13]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHIINKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=65976 SMUNUM_RS05310 WP_002262215.1 1074501..1075808(-) (ciaH) [Streptococcus mutans LP13]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTATCAATAAGGTCAACCGTCAA
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAGAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

100

100

1
  ciaH Streptococcus pneumoniae Rx1

55.632

100

0.556
  ciaH Streptococcus pneumoniae D39

55.632

100

0.556
  ciaH Streptococcus pneumoniae R6

55.632

100

0.556
  ciaH Streptococcus pneumoniae TIGR4

55.632

100

0.556

Multiple sequence alignment