Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE/cglE   Type   Machinery gene
Locus tag   ANG_RS10050 Genome accession   NZ_AP013072
Coordinates   2019161..2019454 (-) Length   97 a.a.
NCBI ID   WP_003035318.1    Uniprot ID   I0SGQ0
Organism   Streptococcus anginosus subsp. whileyi MAS624     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2014161..2024454
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ANG_RS10030 (ANG_2035) - 2016149..2017348 (-) 1200 WP_003035323.1 acetate kinase -
  ANG_RS10035 (ANG_2036) - 2017395..2018348 (-) 954 Protein_1984 class I SAM-dependent methyltransferase -
  ANG_RS10040 (ANG_2037) comGG 2018433..2018759 (-) 327 WP_020999447.1 competence type IV pilus minor pilin ComGG -
  ANG_RS10045 (ANG_2038) comGF/cglF 2018740..2019177 (-) 438 WP_003035329.1 competence type IV pilus minor pilin ComGF Machinery gene
  ANG_RS10050 (ANG_2039) comGE/cglE 2019161..2019454 (-) 294 WP_003035318.1 competence type IV pilus minor pilin ComGE Machinery gene
  ANG_RS10055 (ANG_2040) comYD 2019426..2019854 (-) 429 WP_020999411.1 competence type IV pilus minor pilin ComGD Machinery gene
  ANG_RS10060 (ANG_2041) comYC 2019814..2020131 (-) 318 WP_020998068.1 competence type IV pilus major pilin ComGC Machinery gene
  ANG_RS10065 (ANG_2042) comYB 2020128..2021150 (-) 1023 WP_038677372.1 competence type IV pilus assembly protein ComGB Machinery gene
  ANG_RS10070 (ANG_2043) comYA 2021092..2022033 (-) 942 WP_006268058.1 competence type IV pilus ATPase ComGA Machinery gene
  ANG_RS10075 (ANG_2044) - 2022103..2022468 (-) 366 WP_022525692.1 DUF1033 family protein -
  ANG_RS10080 (ANG_2045) glnA 2022656..2024002 (-) 1347 WP_025272015.1 type I glutamate--ammonia ligase -
  ANG_RS10085 (ANG_2046) - 2024041..2024400 (-) 360 WP_003073972.1 MerR family transcriptional regulator -

Sequence

Protein


Download         Length: 97 a.a.        Molecular weight: 10936.85 Da        Isoelectric Point: 10.4707

>NTDB_id=65552 ANG_RS10050 WP_003035318.1 2019161..2019454(-) (comGE/cglE) [Streptococcus anginosus subsp. whileyi MAS624]
MENLRKQYVRGTILLEALLASAVFAFIVTLLLGQIHQSRQTENDLLKKEEVLRVANMALQTKQSHLTINGIEVRVKKSQQ
GIQIYHGKELIVGVQGK

Nucleotide


Download         Length: 294 bp        

>NTDB_id=65552 ANG_RS10050 WP_003035318.1 2019161..2019454(-) (comGE/cglE) [Streptococcus anginosus subsp. whileyi MAS624]
ATGGAAAATTTAAGAAAACAATACGTTAGAGGAACGATTTTATTAGAAGCTTTATTGGCATCGGCTGTTTTTGCGTTTAT
TGTGACCTTGTTATTGGGGCAGATCCATCAGTCTCGACAGACAGAAAATGATTTACTGAAAAAAGAAGAAGTTCTAAGAG
TGGCTAATATGGCATTACAAACAAAGCAAAGCCATTTAACAATAAACGGTATTGAAGTTCGTGTTAAAAAAAGTCAACAA
GGCATCCAGATTTATCATGGGAAGGAGCTGATTGTCGGTGTTCAAGGCAAATAA

Domains

Predicted by InterproScan.

Type II secretory pathway pseudopilin (ComGE)

(13-92)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SGQ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE/cglE Streptococcus pneumoniae Rx1

55.435

94.845

0.526
  comGE/cglE Streptococcus pneumoniae D39

55.435

94.845

0.526
  comGE/cglE Streptococcus pneumoniae R6

55.435

94.845

0.526
  comGE/cglE Streptococcus pneumoniae TIGR4

55.435

94.845

0.526
  comGE/cglE Streptococcus mitis NCTC 12261

54.348

94.845

0.515
  comGE/cglE Streptococcus mitis SK321

54.348

94.845

0.515
  comYE Streptococcus mutans UA140

42.424

100

0.433
  comYE Streptococcus mutans UA159

42.424

100

0.433

Multiple sequence alignment