Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   SPYJRS4_RS02220 Genome accession   NZ_AP012335
Coordinates   422289..422999 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes JRS4     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 417289..427999
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYJRS4_RS02195 (SPYJRS4_0441) - 417299..418012 (+) 714 WP_313769765.1 MIP/aquaporin family protein -
  SPYJRS4_RS02200 (SPYJRS4_0442) - 418147..418716 (+) 570 WP_011889083.1 hypothetical protein -
  SPYJRS4_RS02205 (SPYJRS4_0443) - 418685..419833 (+) 1149 WP_011889082.1 acetyl-CoA C-acyltransferase -
  SPYJRS4_RS02210 (SPYJRS4_0444) - 419790..421037 (+) 1248 WP_011184289.1 AMP-binding protein -
  SPYJRS4_RS02215 (SPYJRS4_0445) - 421093..422127 (+) 1035 WP_011184290.1 DUF3114 domain-containing protein -
  SPYJRS4_RS02220 (SPYJRS4_0446) vicR 422289..422999 (+) 711 WP_002985645.1 response regulator YycF Regulator
  SPYJRS4_RS02225 (SPYJRS4_0447) vicK 422992..424344 (+) 1353 WP_002990673.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SPYJRS4_RS02230 (SPYJRS4_0448) vicX 424348..425157 (+) 810 WP_011184291.1 MBL fold metallo-hydrolase Regulator
  SPYJRS4_RS02235 (SPYJRS4_0449) rnc 425589..426281 (+) 693 WP_002985639.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=65175 SPYJRS4_RS02220 WP_002985645.1 422289..422999(+) (vicR) [Streptococcus pyogenes JRS4]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=65175 SPYJRS4_RS02220 WP_002985645.1 422289..422999(+) (vicR) [Streptococcus pyogenes JRS4]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACTCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment