Detailed information NTG0065176

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: SPYJRS4_RS02225
• Genome accession: NZ_AP012335
• Coordinates: 422992..424344 (+)
• Length: 450 a.a.
• NCBI ID: WP_002990673.1
• Uniprot ID: A0A660A508
• Organism: Streptococcus pyogenes JRS4
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 417992..429344

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYJRS4_RS02200 (SPYJRS4_0442)	-	418147..418716 (+)	570	WP_011889083.1	hypothetical protein	-
SPYJRS4_RS02205 (SPYJRS4_0443)	-	418685..419833 (+)	1149	WP_011889082.1	acetyl-CoA C-acyltransferase	-
SPYJRS4_RS02210 (SPYJRS4_0444)	-	419790..421037 (+)	1248	WP_011184289.1	AMP-binding protein	-
SPYJRS4_RS02215 (SPYJRS4_0445)	-	421093..422127 (+)	1035	WP_011184290.1	DUF3114 domain-containing protein	-
SPYJRS4_RS02220 (SPYJRS4_0446)	vicR	422289..422999 (+)	711	WP_002985645.1	response regulator YycF	Regulator
SPYJRS4_RS02225 (SPYJRS4_0447)	vicK	422992..424344 (+)	1353	WP_002990673.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SPYJRS4_RS02230 (SPYJRS4_0448)	vicX	424348..425157 (+)	810	WP_011184291.1	MBL fold metallo-hydrolase	Regulator
SPYJRS4_RS02235 (SPYJRS4_0449)	rnc	425589..426281 (+)	693	WP_002985639.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=65176 SPYJRS4_RS02225 WP_002990673.1 422992..424344(+) (vicK) [Streptococcus pyogenes JRS4]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=65176 SPYJRS4_RS02225 WP_002990673.1 422992..424344(+) (vicK) [Streptococcus pyogenes JRS4]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTATCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

3D structure

• AlphaFold DB: A0A660A508

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64