Detailed information NTG0645602

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: L1A12_RS05935
• Genome accession: NZ_CP090882
• Coordinates: 1189791..1190639 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705300.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain CH2241
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1184791..1195639

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A12_RS05920 (L1A12_05920)	-	1185032..1185391 (-)	360	WP_001237219.1	YbaN family protein	-
L1A12_RS05925 (L1A12_05925)	topA	1185612..1187699 (-)	2088	WP_000179680.1	type I DNA topoisomerase	-
L1A12_RS05930 (L1A12_05930)	-	1187866..1188909 (-)	1044	WP_001812883.1	TIGR00341 family protein	-
L1A12_RS10645	-	1189486..1189608 (+)	123	WP_001814242.1	hypothetical protein	-
L1A12_RS05935 (L1A12_05935)	dprA/cilB/dalA	1189791..1190639 (-)	849	WP_000705300.1	DNA-processing protein DprA	Machinery gene
L1A12_RS05940 (L1A12_05940)	-	1190725..1191414 (-)	690	WP_000643970.1	sugar phosphate nucleotidyltransferase	-
L1A12_RS05945 (L1A12_05945)	-	1191426..1192304 (-)	879	WP_000837618.1	DMT family transporter	-
L1A12_RS05950 (L1A12_05950)	licA	1192294..1193163 (-)	870	WP_000411215.1	choline kinase LicA	-
L1A12_RS05955 (L1A12_05955)	-	1193180..1194202 (-)	1023	WP_000609885.1	ribitol-5-phosphate dehydrogenase	-
L1A12_RS05960 (L1A12_05960)	-	1194207..1194914 (-)	708	WP_000638502.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31048.70 Da
• Isoelectric Point: 5.4047

>NTDB_id=645602 L1A12_RS05935 WP_000705300.1 1189791..1190639(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain CH2241]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLALSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDIFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=645602 L1A12_RS05935 WP_000705300.1 1189791..1190639(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain CH2241]
ATGAAAATTACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATCTCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAACAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGCTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACCTGTGAGCGAGCAATGGAAGAA
GGACGCGATATCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.291	100	0.993
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	97.872	100	0.979
dprA/cilB/dalA	Streptococcus mitis SK321	97.163	100	0.972
dprA	Streptococcus mutans UA159	62.857	99.291	0.624
dprA	Lactococcus lactis subsp. cremoris KW2	55.714	99.291	0.553
dprA	Staphylococcus aureus N315	37.102	100	0.372