NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	LV497_RS00945	Genome accession	NZ_CP090007
Coordinates	206166..206840 (-)	Length	224 a.a.
NCBI ID	WP_073688405.1	Uniprot ID	-
Organism	Streptococcus salivarius strain SALI-10
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 201166..211840

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LV497_RS00920 (LV497_00920)	-	201480..202757 (-)	1278	WP_104021054.1	pyrimidine-nucleoside phosphorylase	-
LV497_RS00925 (LV497_00925)	-	202754..203344 (-)	591	WP_045768632.1	class I SAM-dependent methyltransferase	-
LV497_RS00930 (LV497_00930)	coaA	203457..204377 (+)	921	WP_104021193.1	type I pantothenate kinase	-
LV497_RS00935 (LV497_00935)	rpsT	204447..204683 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
LV497_RS00940 (LV497_00940)	ciaH	204761..206176 (-)	1416	WP_084869337.1	cell wall metabolism sensor histidine kinase WalK	Regulator
LV497_RS00945 (LV497_00945)	ciaR	206166..206840 (-)	675	WP_073688405.1	response regulator transcription factor	Regulator
LV497_RS00950 (LV497_00950)	-	207037..208707 (-)	1671	WP_245084905.1	formate--tetrahydrofolate ligase	-
LV497_RS00955 (LV497_00955)	-	208902..209585 (+)	684	WP_084869336.1	phosphopantothenate--cysteine ligase	-
LV497_RS00960 (LV497_00960)	coaC	209578..210123 (+)	546	WP_084869334.1	phosphopantothenoylcysteine decarboxylase	-
LV497_RS00965 (LV497_00965)	-	210152..210724 (+)	573	WP_245084908.1	ECF transporter S component	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25385.05 Da Isoelectric Point: 4.3406

                                >NTDB_id=640093 LV497_RS00945 WP_073688405.1 206166..206840(-) (ciaR) [Streptococcus salivarius strain SALI-10]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY

FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKHAD

Nucleotide

Download Length: 675 bp

                                >NTDB_id=640093 LV497_RS00945 WP_073688405.1 206166..206840(-) (ciaR) [Streptococcus salivarius strain SALI-10]

ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT

GATGCAAGTCTTTGATGGTGATGAAGGCCTTTACGAAGCTGAAAGTGGCGTTTATGATTTGATTCTTTTAGACCTTATGT

TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT

AAGGAAAGTCTAGATGATAAAGGCCACGGCTTTGAACTTGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA

GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG

TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC

TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT

ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA

GAAGTGTGGGGTATATTTTGAAGCATGCTGACTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	88.235	98.661	0.871
ciaR	Streptococcus pneumoniae D39	88.235	98.661	0.871
ciaR	Streptococcus pneumoniae R6	88.235	98.661	0.871
ciaR	Streptococcus pneumoniae TIGR4	88.235	98.661	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384

Detailed information NTG0640093