Detailed information NTG0061886

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: SIR_RS15625
• Genome accession: NC_022246
• Coordinates: 1212231..1214381 (-)
• Length: 716 a.a.
• NCBI ID: WP_021002970.1
• Uniprot ID: T1ZFN9
• Organism: Streptococcus intermedius B196
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1207231..1219381

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SIR_RS15595	-	1207385..1207564 (+)	180	WP_041787481.1	hypothetical protein	-
SIR_RS15600 (SIR_1150)	-	1207583..1208296 (+)	714	WP_021002966.1	CPBP family intramembrane glutamic endopeptidase	-
SIR_RS15605 (SIR_1151)	comE/blpR	1208465..1209211 (+)	747	WP_041787711.1	response regulator transcription factor	Regulator
SIR_RS15610 (SIR_1152)	-	1209213..1210529 (+)	1317	WP_021002968.1	sensor histidine kinase	-
SIR_RS15615 (SIR_1153)	-	1210610..1210762 (-)	153	WP_003073362.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SIR_RS15620 (SIR_1154)	-	1210859..1212220 (-)	1362	WP_021002969.1	bacteriocin secretion accessory protein	-
SIR_RS15625 (SIR_1155)	comA/nlmT	1212231..1214381 (-)	2151	WP_021002970.1	peptide cleavage/export ABC transporter	Regulator
SIR_RS15630 (SIR_1156)	-	1214862..1215236 (+)	375	WP_041787483.1	hypothetical protein	-
SIR_RS15635 (SIR_1157)	-	1215309..1215914 (-)	606	WP_021002972.1	superoxide dismutase	-
SIR_RS15640 (SIR_1158)	holA	1215985..1217022 (-)	1038	WP_021002973.1	DNA polymerase III subunit delta	-
SIR_RS15645 (SIR_1159)	cvfB	1217082..1217936 (-)	855	WP_021002974.1	RNA-binding virulence regulatory protein CvfB	-
SIR_RS15650 (SIR_1160)	frr	1218049..1218606 (-)	558	WP_020998907.1	ribosome recycling factor	-
SIR_RS15655 (SIR_1161)	pyrH	1218610..1219350 (-)	741	WP_003073377.1	UMP kinase	-

Sequence

Protein

• Length: 716 a.a.
• Molecular weight: 80412.94 Da
• Isoelectric Point: 9.3464

>NTDB_id=61886 SIR_RS15625 WP_021002970.1 1212231..1214381(-) (comA/nlmT) [Streptococcus intermedius B196]
MNVKKTFVPQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTSKEGTTALGIVQAAQEIGFETRPIQGDMSLFDMEAIP
YPFIVHVQKKGKLPHYYVIYKNTKKGLLVGDPDPSVKITKISKETFATEWTGVAIFLAPEPSYKPHKDKKNGLISLIPLI
FKQKMLVTYIVLASLLVTLINIVGSYYLQGILDEYIPNQMRSTLGIVSIGLIITYILQQMMSFSRDYLLIVLSQRLTIDV
ILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDLSILIIVGGVLLLQNTNLFFLTLLAIPIYTVI
IFAFIKPFEKMNHDVMQSNSMVNSAIIEDINGIETIKSLTSEEARYQKIDSEFVNYLDKSFTLSKYSIFQTTLKQGFQLI
LNVLILWLGAHLVISEKISIGQLITFTALLSYFTNSLESIINLQTKLQSAKVANKRLNEVYLVESEFKTKQTLTEKGFLA
GDITFHNVSYKYGFGRDTLSDINLTIKTGDKVSLVGISGSGKTTLAKMMVHFYEPYKGQIRLNGNDLKMIDKKTLRQYIN
YLPQQAYIFSGSILENLTLGTNQIFSQKEIIRACEIAEIRSDIEQMPMGYQTELSDGAGLSGGQRQRIALARALLTKSPI
LILDEATSGLDVLTEKKVIDNLMGLKDKTIIFVAHRLSISKRTNQVIVLDKGQIIETGSHAELMERQGFYHHLFNK

Nucleotide

• Length: 2151 bp

>NTDB_id=61886 SIR_RS15625 WP_021002970.1 1212231..1214381(-) (comA/nlmT) [Streptococcus intermedius B196]
GTGAATGTTAAGAAAACATTTGTTCCTCAAATAGATGCAAGAGATTGCGGTGTCGCTGCGCTTGCTTCCATTGCAAAATA
CTATGGTTCAGACTACTCTCTTGCACATCTGAGAGAACTTGCTAAGACAAGTAAAGAAGGGACAACGGCTCTTGGAATTG
TTCAAGCAGCGCAAGAAATAGGTTTTGAGACACGACCGATTCAAGGGGATATGTCTTTGTTTGATATGGAAGCTATTCCC
TATCCTTTTATCGTTCATGTTCAGAAAAAAGGTAAACTCCCACATTATTATGTTATCTATAAAAATACGAAAAAAGGTCT
GCTAGTTGGAGATCCTGATCCAAGTGTAAAAATAACCAAGATCTCAAAAGAAACATTTGCAACAGAATGGACTGGTGTTG
CTATTTTTTTAGCACCAGAACCTAGCTATAAACCACATAAGGATAAGAAAAATGGTTTGATAAGCTTAATTCCTCTTATT
TTTAAACAGAAAATGCTGGTCACCTATATTGTTTTAGCTAGTCTGCTTGTGACACTCATCAATATTGTTGGATCTTACTA
CCTACAAGGAATTTTAGACGAATACATTCCAAATCAAATGAGATCAACTCTTGGAATAGTGTCTATTGGTCTGATTATTA
CTTATATTTTGCAGCAAATGATGAGTTTTTCCAGAGATTACTTATTGATTGTACTTAGTCAGCGGCTGACCATTGATGTG
ATTTTATCATATATTCGACACATTTTTGAATTACCAATGTCTTTTTTTGCTACGAGACGCACTGGAGAGATTATTTCTCG
TTTTACAGATGCTAATTCCATTATTGATGCTCTCGCTTCTACAATACTTTCACTCTTTCTTGACCTTTCTATTTTGATAA
TAGTAGGAGGGGTATTATTATTACAGAATACCAACCTTTTCTTCCTCACTCTGCTTGCTATTCCTATCTATACGGTGATT
ATTTTTGCTTTTATAAAGCCTTTTGAAAAAATGAATCATGACGTCATGCAAAGCAATTCCATGGTAAATTCTGCTATTAT
CGAAGATATTAATGGCATTGAAACCATTAAATCTTTAACAAGCGAAGAAGCTCGTTACCAAAAGATAGACAGCGAATTTG
TAAATTATTTAGATAAATCTTTTACGCTTAGTAAATATTCTATTTTTCAAACAACCCTTAAACAAGGATTTCAATTAATT
TTAAATGTGCTTATTTTATGGCTCGGTGCGCATTTAGTTATATCTGAGAAAATCTCAATTGGGCAGCTCATCACATTTAC
GGCTCTACTTTCTTATTTTACAAATTCTCTTGAAAGTATTATTAATCTGCAAACTAAGCTGCAGTCGGCTAAGGTTGCTA
ACAAGCGGTTGAATGAAGTTTATTTAGTAGAGTCTGAATTTAAAACTAAGCAAACACTTACAGAGAAAGGTTTCTTGGCT
GGTGATATTACGTTCCATAATGTCTCCTATAAATACGGCTTCGGACGAGATACGTTATCGGATATTAACTTAACAATAAA
AACAGGAGATAAGGTGAGCTTAGTCGGCATCAGTGGTTCGGGAAAGACAACACTTGCCAAAATGATGGTTCATTTTTATG
AGCCTTATAAAGGGCAAATCCGTCTCAATGGAAATGACCTTAAAATGATTGATAAGAAGACACTTCGTCAATATATCAAT
TATTTACCACAACAAGCCTATATTTTTAGTGGTTCCATCTTAGAAAATCTTACATTAGGGACGAATCAAATATTTTCTCA
AAAAGAGATTATTCGCGCTTGTGAAATTGCAGAAATTCGTTCGGATATTGAACAAATGCCTATGGGATATCAAACAGAAT
TGTCCGATGGAGCTGGTCTATCAGGTGGACAAAGGCAACGAATTGCTCTAGCACGCGCCCTCTTAACAAAGTCACCAATT
CTTATTCTTGACGAAGCAACGAGCGGATTGGATGTTCTAACTGAGAAAAAGGTCATTGACAATCTGATGGGTTTAAAAGA
CAAAACGATTATTTTTGTTGCTCATCGTCTCAGCATTTCAAAGCGGACAAATCAGGTTATTGTTCTTGATAAAGGGCAGA
TTATTGAAACTGGATCCCACGCTGAATTGATGGAAAGACAAGGCTTTTATCATCATTTATTTAATAAATAA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (499-648)

• ABC transporter transmembrane region (ABC_membrane) (168-437)

• Peptidase C39 family (Peptidase_C39) (6-141)

3D structure

• AlphaFold DB: T1ZFN9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	71.932	99.022	0.712
comA	Streptococcus mitis NCTC 12261	66.9	99.581	0.666
comA	Streptococcus mitis SK321	66.76	99.581	0.665
comA	Streptococcus gordonii str. Challis substr. CH1	66.339	99.581	0.661
comA	Streptococcus pneumoniae D39	66.199	99.581	0.659
comA	Streptococcus pneumoniae R6	66.199	99.581	0.659
comA	Streptococcus pneumoniae Rx1	66.199	99.581	0.659
comA	Streptococcus pneumoniae TIGR4	65.778	99.581	0.655