Detailed information NTG0061885

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SIR_RS15605
• Genome accession: NC_022246
• Coordinates: 1208465..1209211 (+)
• Length: 248 a.a.
• NCBI ID: WP_041787711.1
• Uniprot ID: -
• Organism: Streptococcus intermedius B196
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1203465..1214211

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SIR_RS15555 (SIR_1142)	-	1203621..1203839 (-)	219	WP_021002958.1	Blp family class II bacteriocin	-
SIR_RS15560 (SIR_1143)	-	1204067..1204387 (-)	321	WP_021002959.1	hypothetical protein	-
SIR_RS15565 (SIR_1144)	-	1204538..1204828 (-)	291	WP_021002960.1	bacteriocin immunity protein	-
SIR_RS20345	-	1204895..1205113 (-)	219	Protein_1132	garvicin Q family class II bacteriocin	-
SIR_RS15570 (SIR_1145)	-	1205121..1205441 (-)	321	WP_039677379.1	hypothetical protein	-
SIR_RS15580 (SIR_1147)	-	1206118..1206339 (-)	222	WP_021002963.1	Blp family class II bacteriocin	-
SIR_RS15585 (SIR_1148)	-	1206681..1206872 (-)	192	WP_021002964.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SIR_RS15590 (SIR_1149)	-	1206892..1207140 (-)	249	WP_021002965.1	bacteriocin class II family protein	-
SIR_RS15595	-	1207385..1207564 (+)	180	WP_041787481.1	hypothetical protein	-
SIR_RS15600 (SIR_1150)	-	1207583..1208296 (+)	714	WP_021002966.1	CPBP family intramembrane glutamic endopeptidase	-
SIR_RS15605 (SIR_1151)	comE/blpR	1208465..1209211 (+)	747	WP_041787711.1	response regulator transcription factor	Regulator
SIR_RS15610 (SIR_1152)	-	1209213..1210529 (+)	1317	WP_021002968.1	sensor histidine kinase	-
SIR_RS15615 (SIR_1153)	-	1210610..1210762 (-)	153	WP_003073362.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SIR_RS15620 (SIR_1154)	-	1210859..1212220 (-)	1362	WP_021002969.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 248 a.a.
• Molecular weight: 28755.16 Da
• Isoelectric Point: 7.3918

>NTDB_id=61885 SIR_RS15605 WP_041787711.1 1208465..1209211(+) (comE/blpR) [Streptococcus intermedius B196]
MNIFILEDDLTQQYYMETIVEEIIEKHRLQYHHFEVFGKPKQLLEAISEKGSHQVFFLDIEIKTEEKKGLDVAKKIREID
PYAIIVFVTSHSELMPAAFKLQVGALDYLDKSLSKEALKKRIETALLHTENLTGKGLADDSLLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLSDMLKKEKRFYQCHRSFVVNPANVHQVDKVNHILHFQNGATCLVSRSKIKGLTEA
IAALHWRE

Nucleotide

• Length: 747 bp

>NTDB_id=61885 SIR_RS15605 WP_041787711.1 1208465..1209211(+) (comE/blpR) [Streptococcus intermedius B196]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
TCGTCTTCAATATCACCATTTTGAAGTTTTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAAGCCATC
AGGTTTTCTTTTTGGATATTGAAATCAAAACTGAAGAAAAAAAGGGCTTAGACGTCGCCAAAAAGATACGCGAGATAGAT
CCTTATGCCATTATTGTCTTTGTAACCAGTCACTCTGAATTGATGCCGGCAGCGTTTAAACTGCAAGTCGGCGCCCTTGA
CTATCTTGACAAATCGTTATCAAAAGAAGCTTTGAAAAAACGGATCGAAACTGCGCTGCTACATACTGAAAACCTAACAG
GCAAAGGCCTGGCAGACGATTCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCGTTTAAAGATATTCTTTAC
ATTGAAACTTCCTCTCGTCCTCACCGTTTAGTACTTTACACACATAGAGGGCGTACGGAATTTACTGCCAATCTTTCAGA
TATGTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGTTCCTTTGTTGTTAACCCAGCTAATGTTCATCAAGTGGATA
AAGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTGTTTCTAGATCAAAAATAAAAGGGTTAACAGAAGCT
ATTGCAGCCCTGCACTGGAGGGAATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-123)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	50.206	97.984	0.492
comE/comE1	Streptococcus equinus JB1	45.992	95.565	0.44