Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SIR_RS14120 Genome accession   NC_022246
Coordinates   874359..875033 (-) Length   224 a.a.
NCBI ID   WP_003036714.1    Uniprot ID   -
Organism   Streptococcus intermedius B196     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 869359..880033
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS14100 (SIR_0855) rpsT 870119..870355 (+) 237 WP_003072853.1 30S ribosomal protein S20 -
  SIR_RS14105 (SIR_0856) - 870420..870929 (+) 510 WP_021002771.1 DNA topology modulation protein -
  SIR_RS14110 (SIR_0857) - 871299..872747 (+) 1449 WP_021002772.1 alpha-amylase -
  SIR_RS14115 (SIR_0858) ciaH 873023..874369 (-) 1347 WP_003072859.1 sensor histidine kinase Regulator
  SIR_RS14120 (SIR_0859) ciaR 874359..875033 (-) 675 WP_003036714.1 response regulator transcription factor Regulator
  SIR_RS14125 (SIR_0860) - 875295..875738 (-) 444 WP_020998689.1 hypothetical protein -
  SIR_RS14130 (SIR_0861) - 876038..876778 (-) 741 WP_021002773.1 alpha/beta hydrolase -
  SIR_RS14140 (SIR_0863) rplS 877023..877370 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  SIR_RS14145 (SIR_0864) - 877520..878479 (-) 960 WP_021002774.1 ROK family glucokinase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25373.03 Da        Isoelectric Point: 4.2408

>NTDB_id=61877 SIR_RS14120 WP_003036714.1 874359..875033(-) (ciaR) [Streptococcus intermedius B196]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=61877 SIR_RS14120 WP_003036714.1 874359..875033(-) (ciaR) [Streptococcus intermedius B196]
ATGATTAAGATTCTATTAGTAGAAGATGACCTCGGTTTATCTAACTCAGTATTTGATTTTTTAGATGACTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTACGAAGCTGAAAGTGGTGTGTATGATCTTATCTTACTTGATTTGATGT
TACCGGAAAAAGATGGTTTTCAAGTATTGAAGGAATTACGTGAAAAAGGTGTTACAACACCGGTATTGATTATGACAGCT
AAAGAGAGTTTGAATGATAAAGGACATGGCTTTGAGCTGGGAGCTGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGTGATGTAACCA
TTAATTTGTCAACGAACACTACACTTGTAGATGGAAATGAAGTAGAGTTACTCGGAAAAGAATTTGATTTATTAGTATAT
TTCTTGCAGAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGATTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATTCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAACCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.518

100

0.915
  ciaR Streptococcus pneumoniae D39

91.518

100

0.915
  ciaR Streptococcus pneumoniae R6

91.518

100

0.915
  ciaR Streptococcus pneumoniae TIGR4

91.518

100

0.915
  ciaR Streptococcus mutans UA159

89.686

99.554

0.893
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment