Detailed information NTG0061810

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: SCR2_RS02270
• Genome accession: NC_022245
• Coordinates: 441484..442158 (-)
• Length: 224 a.a.
• NCBI ID: WP_020997643.1
• Uniprot ID: -
• Organism: Streptococcus constellatus subsp. pharyngis C818
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	434175..444243	441484..442158	within	0

Gene organization within MGE regions

Location: 434175..444243

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCR2_RS02225 (SCR2_0442)	comFA/cflA	434175..435476 (+)	1302	WP_020997640.1	DEAD/DEAH box helicase	Machinery gene
SCR2_RS02230 (SCR2_0443)	-	435473..436138 (+)	666	WP_006267632.1	ComF family protein	-
SCR2_RS02235 (SCR2_0444)	hpf	436217..436759 (+)	543	WP_006267638.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
SCR2_RS02240 (SCR2_0445)	rsmD	436956..437495 (+)	540	WP_020997641.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SCR2_RS02245 (SCR2_0446)	coaD	437485..437982 (+)	498	WP_006267255.1	pantetheine-phosphate adenylyltransferase	-
SCR2_RS02250 (SCR2_0447)	sepM	437963..439018 (+)	1056	WP_020997642.1	SepM family pheromone-processing serine protease	Regulator
SCR2_RS02255 (SCR2_0448)	-	439305..439862 (+)	558	WP_006267391.1	YutD family protein	-
SCR2_RS02260 (SCR2_0449)	rlmN	439896..440978 (+)	1083	WP_006269861.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SCR2_RS02265 (SCR2_0450)	-	440971..441489 (+)	519	WP_003070167.1	VanZ family protein	-
SCR2_RS02270 (SCR2_0451)	cclA/cilC	441484..442158 (-)	675	WP_020997643.1	prepilin peptidase	Machinery gene
SCR2_RS02275 (SCR2_0452)	-	442309..442836 (+)	528	WP_006267546.1	Dps family protein	-
SCR2_RS02280 (SCR2_0454)	-	443053..444243 (-)	1191	WP_006267506.1	site-specific integrase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25312.66 Da
• Isoelectric Point: 8.5004

>NTDB_id=61810 SCR2_RS02270 WP_020997643.1 441484..442158(-) (cclA/cilC) [Streptococcus constellatus subsp. pharyngis C818]
MIHFYFFLVGSIVASFLGLVVDRFPEQSIITPASHCNVCRQKLAPRDLIPVLSQLINRLRCRFCNSKIPIRYILLELTGG
CLFLATSLGYLNINRLVLLAMGMTLSLYDQREQEYPLLIWLIFHIFLLFLTSFNLLMVAFLALGILTHFVDLRIGAGDFL
FLASCSTIFHLTEVLLIIQIASIIGLLLFGLKSKKDRLAFVPCLFCGGSILIMIQFIVLHQNAL

Nucleotide

• Length: 675 bp

>NTDB_id=61810 SCR2_RS02270 WP_020997643.1 441484..442158(-) (cclA/cilC) [Streptococcus constellatus subsp. pharyngis C818]
ATGATTCATTTTTATTTTTTCTTGGTTGGAAGTATTGTAGCTTCCTTTTTAGGACTGGTCGTTGATCGCTTTCCTGAGCA
GTCTATTATCACACCTGCTAGTCATTGCAACGTTTGTAGACAGAAATTAGCACCTCGTGATTTAATTCCTGTTCTTTCAC
AGCTTATCAATCGGCTGCGTTGCCGTTTTTGCAACTCAAAAATTCCCATCCGTTACATCCTTCTAGAACTAACTGGTGGC
TGTCTCTTTCTTGCAACATCTTTAGGTTATCTAAACATCAACCGGCTCGTTTTGCTTGCAATGGGAATGACCTTATCCCT
TTATGATCAAAGAGAACAAGAATATCCTCTCCTCATCTGGTTAATCTTCCATATTTTTCTCCTTTTTTTGACAAGCTTCA
ATCTTTTAATGGTTGCTTTTTTAGCACTTGGGATTTTGACTCACTTCGTTGATTTACGTATCGGTGCAGGAGACTTTCTT
TTTCTGGCATCTTGCTCAACTATTTTTCATCTGACTGAAGTTCTTCTCATTATTCAAATTGCTAGTATCATTGGTCTGCT
CCTTTTTGGTTTAAAATCAAAAAAAGACAGGTTAGCCTTTGTTCCCTGTCTTTTCTGTGGTGGCAGCATCCTGATAATGA
TACAATTTATCGTTCTTCACCAAAATGCCTTATGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-87)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus mitis SK321	58.019	94.643	0.549
cclA/cilC	Streptococcus mitis NCTC 12261	57.547	94.643	0.545
cclA/cilC	Streptococcus pneumoniae TIGR4	57.075	94.643	0.54
cclA/cilC	Streptococcus pneumoniae Rx1	56.604	94.643	0.536
cclA/cilC	Streptococcus pneumoniae D39	56.604	94.643	0.536
cclA/cilC	Streptococcus pneumoniae R6	56.604	94.643	0.536