Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SAIN_RS05265 Genome accession   NC_022244
Coordinates   1069895..1070569 (-) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus C1051     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1064895..1075569
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SAIN_RS05255 (SAIN_1022) - 1066634..1068082 (+) 1449 WP_021001736.1 alpha-amylase -
  SAIN_RS10090 - 1068279..1068413 (-) 135 WP_256381214.1 hypothetical protein -
  SAIN_RS05260 (SAIN_1023) ciaH 1068559..1069905 (-) 1347 WP_021001737.1 sensor histidine kinase Regulator
  SAIN_RS05265 (SAIN_1024) ciaR 1069895..1070569 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  SAIN_RS05270 (SAIN_1025) - 1070842..1071294 (-) 453 WP_021001738.1 hypothetical protein -
  SAIN_RS05275 (SAIN_1026) - 1071619..1072362 (-) 744 WP_003024349.1 alpha/beta fold hydrolase -
  SAIN_RS05280 (SAIN_1027) - 1072822..1073070 (+) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  SAIN_RS05285 (SAIN_1028) - 1073067..1073363 (+) 297 WP_041784012.1 type II toxin-antitoxin system RelE family toxin -
  SAIN_RS05290 (SAIN_1029) - 1073494..1074192 (-) 699 WP_021001740.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=61772 SAIN_RS05265 WP_003024352.1 1069895..1070569(-) (ciaR) [Streptococcus anginosus C1051]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=61772 SAIN_RS05265 WP_003024352.1 1069895..1070569(-) (ciaR) [Streptococcus anginosus C1051]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCGGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATCTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment