Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   SCI_RS02365 Genome accession   NC_022238
Coordinates   459891..460565 (-) Length   224 a.a.
NCBI ID   WP_020997643.1    Uniprot ID   -
Organism   Streptococcus constellatus subsp. pharyngis C1050     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 434024..467336 459891..460565 within 0


Gene organization within MGE regions


Location: 434024..467336
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCI_RS02235 (SCI_0444) - 434462..435238 (-) 777 WP_006267458.1 aminoglycoside 3'-phosphotransferase -
  SCI_RS02240 (SCI_0445) rlmD 435295..436659 (+) 1365 WP_006267121.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  SCI_RS02245 (SCI_0446) - 437517..438449 (-) 933 WP_006267664.1 nitronate monooxygenase -
  SCI_RS02250 (SCI_0447) - 438784..439017 (+) 234 WP_003070208.1 DUF1858 domain-containing protein -
  SCI_RS02255 (SCI_0448) - 439017..440378 (+) 1362 WP_006267202.1 DUF438 domain-containing protein -
  SCI_RS02260 (SCI_0449) - 440391..440645 (+) 255 WP_006267273.1 DUF1912 family protein -
  SCI_RS02265 (SCI_0451) - 441032..441610 (+) 579 WP_003070202.1 GNAT family N-acetyltransferase -
  SCI_RS02270 (SCI_0452) - 441607..442413 (+) 807 WP_020999313.1 hypothetical protein -
  SCI_RS02275 (SCI_0453) - 442567..445215 (+) 2649 WP_006267276.1 valine--tRNA ligase -
  SCI_RS02280 - 445223..445612 (+) 390 WP_006267502.1 hypothetical protein -
  SCI_RS11115 (SCI_0456) - 447106..448614 (-) 1509 WP_020999314.1 YSIRK signal domain/LPXTG anchor domain surface protein -
  SCI_RS10150 (SCI_0457) - 448753..449633 (-) 881 Protein_433 ISAs1 family transposase -
  SCI_RS10155 (SCI_0458) - 449810..450079 (-) 270 Protein_434 IS30 family transposase -
  SCI_RS10160 (SCI_0459) - 450184..450908 (-) 725 Protein_435 ISL3 family transposase -
  SCI_RS02310 (SCI_0460) cysK 450862..451791 (-) 930 WP_020997639.1 cysteine synthase A -
  SCI_RS02315 (SCI_0461) - 451890..452525 (-) 636 WP_003035211.1 YigZ family protein -
  SCI_RS02320 (SCI_0462) comFA/cflA 452582..453883 (+) 1302 WP_020997640.1 DEAD/DEAH box helicase Machinery gene
  SCI_RS02325 (SCI_0463) - 453880..454545 (+) 666 WP_006267632.1 ComF family protein -
  SCI_RS02330 (SCI_0464) hpf 454624..455166 (+) 543 WP_006267638.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  SCI_RS02335 (SCI_0465) rsmD 455363..455902 (+) 540 WP_020997641.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  SCI_RS02340 (SCI_0466) coaD 455892..456389 (+) 498 WP_006267255.1 pantetheine-phosphate adenylyltransferase -
  SCI_RS02345 (SCI_0467) sepM 456370..457425 (+) 1056 WP_020997642.1 SepM family pheromone-processing serine protease Regulator
  SCI_RS02350 (SCI_0468) - 457712..458269 (+) 558 WP_006267391.1 YutD family protein -
  SCI_RS02355 (SCI_0469) rlmN 458303..459385 (+) 1083 WP_006269861.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  SCI_RS02360 (SCI_0470) - 459378..459896 (+) 519 WP_003070167.1 VanZ family protein -
  SCI_RS02365 (SCI_0471) cclA/cilC 459891..460565 (-) 675 WP_020997643.1 A24 family peptidase Machinery gene
  SCI_RS02370 (SCI_0472) - 460716..461243 (+) 528 WP_006267546.1 DNA starvation/stationary phase protection protein -
  SCI_RS02375 (SCI_0474) - 461460..462650 (-) 1191 WP_006267506.1 site-specific integrase -
  SCI_RS02380 (SCI_0475) - 462726..462929 (-) 204 WP_002983016.1 excisionase -
  SCI_RS02385 (SCI_0476) - 463359..463610 (-) 252 WP_006267285.1 helix-turn-helix domain-containing protein -
  SCI_RS02390 (SCI_0477) - 463591..464034 (-) 444 WP_006267609.1 RNA polymerase sigma factor -
  SCI_RS02395 (SCI_0478) - 464375..465709 (-) 1335 WP_006267371.1 MATE family efflux transporter -
  SCI_RS10170 (SCI_0479) - 466343..466667 (+) 325 Protein_454 plasmid mobilization protein -
  SCI_RS10875 - 466634..466864 (+) 231 Protein_455 relaxase/mobilization nuclease domain-containing protein -
  SCI_RS10180 - 466836..466988 (+) 153 WP_080654533.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25312.66 Da        Isoelectric Point: 8.5004

>NTDB_id=61584 SCI_RS02365 WP_020997643.1 459891..460565(-) (cclA/cilC) [Streptococcus constellatus subsp. pharyngis C1050]
MIHFYFFLVGSIVASFLGLVVDRFPEQSIITPASHCNVCRQKLAPRDLIPVLSQLINRLRCRFCNSKIPIRYILLELTGG
CLFLATSLGYLNINRLVLLAMGMTLSLYDQREQEYPLLIWLIFHIFLLFLTSFNLLMVAFLALGILTHFVDLRIGAGDFL
FLASCSTIFHLTEVLLIIQIASIIGLLLFGLKSKKDRLAFVPCLFCGGSILIMIQFIVLHQNAL

Nucleotide


Download         Length: 675 bp        

>NTDB_id=61584 SCI_RS02365 WP_020997643.1 459891..460565(-) (cclA/cilC) [Streptococcus constellatus subsp. pharyngis C1050]
ATGATTCATTTTTATTTTTTCTTGGTTGGAAGTATTGTAGCTTCCTTTTTAGGACTGGTCGTTGATCGCTTTCCTGAGCA
GTCTATTATCACACCTGCTAGTCATTGCAACGTTTGTAGACAGAAATTAGCACCTCGTGATTTAATTCCTGTTCTTTCAC
AGCTTATCAATCGGCTGCGTTGCCGTTTTTGCAACTCAAAAATTCCCATCCGTTACATCCTTCTAGAACTAACTGGTGGC
TGTCTCTTTCTTGCAACATCTTTAGGTTATCTAAACATCAACCGGCTCGTTTTGCTTGCAATGGGAATGACCTTATCCCT
TTATGATCAAAGAGAACAAGAATATCCTCTCCTCATCTGGTTAATCTTCCATATTTTTCTCCTTTTTTTGACAAGCTTCA
ATCTTTTAATGGTTGCTTTTTTAGCACTTGGGATTTTGACTCACTTCGTTGATTTACGTATCGGTGCAGGAGACTTTCTT
TTTCTGGCATCTTGCTCAACTATTTTTCATCTGACTGAAGTTCTTCTCATTATTCAAATTGCTAGTATCATTGGTCTGCT
CCTTTTTGGTTTAAAATCAAAAAAAGACAGGTTAGCCTTTGTTCCCTGTCTTTTCTGTGGTGGCAGCATCCTGATAATGA
TACAATTTATCGTTCTTCACCAAAATGCCTTATGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-87)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus mitis SK321

58.019

94.643

0.549
  cclA/cilC Streptococcus mitis NCTC 12261

57.547

94.643

0.545
  cclA/cilC Streptococcus pneumoniae TIGR4

57.075

94.643

0.54
  cclA/cilC Streptococcus pneumoniae Rx1

56.604

94.643

0.536
  cclA/cilC Streptococcus pneumoniae D39

56.604

94.643

0.536
  cclA/cilC Streptococcus pneumoniae R6

56.604

94.643

0.536

Multiple sequence alignment