Detailed information NTG0600071

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: K6973_RS00380
• Genome accession: NZ_CP082206
• Coordinates: 60499..61410 (+)
• Length: 303 a.a.
• NCBI ID: WP_138124363.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae strain DY107
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 55499..66410

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6973_RS00360 (K6973_00360)	purE	57004..57492 (+)	489	WP_129555152.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
K6973_RS00365 (K6973_00365)	purK	57479..58561 (+)	1083	WP_222819420.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
K6973_RS00370 (K6973_00370)	-	58690..58917 (+)	228	WP_222819421.1	phosphoribosylaminoimidazole carboxylase	-
K6973_RS00375 (K6973_00375)	purB	59065..60357 (+)	1293	WP_222819422.1	adenylosuccinate lyase	-
K6973_RS00380 (K6973_00380)	comR	60499..61410 (+)	912	WP_138124363.1	XRE family transcriptional regulator	Regulator
K6973_RS00385 (K6973_00385)	comS	61498..61596 (+)	99	WP_014611913.1	quorum-sensing system DWW-type pheromone	Regulator
K6973_RS00390 (K6973_00390)	ruvB	61630..62628 (+)	999	WP_222819423.1	Holliday junction branch migration DNA helicase RuvB	-
K6973_RS00395 (K6973_00395)	-	62763..63194 (+)	432	WP_222819424.1	low molecular weight protein-tyrosine-phosphatase	-
K6973_RS00400 (K6973_00400)	-	63223..63624 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
K6973_RS00405 (K6973_00405)	-	63621..65396 (+)	1776	WP_218654988.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35896.44 Da
• Isoelectric Point: 4.6217

>NTDB_id=600071 K6973_RS00380 WP_138124363.1 60499..61410(+) (comR) [Streptococcus dysgalactiae strain DY107]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDGKLQVRESQFDEIFENYYDQLPEEEKIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKKTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQQEWDKDIHPS

Nucleotide

• Length: 912 bp

>NTDB_id=600071 K6973_RS00380 WP_138124363.1 60499..61410(+) (comR) [Streptococcus dysgalactiae strain DY107]
ATGTTAGAGCATTTTGGAGAAAAAGTGAGAGGACTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTATCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATGGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAAGAAAAAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAAAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTTACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTATTAGAAGATTTATTTCTATTAAATAATATTCTTTTAT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGCCATTTTATTATGTCA
ACCATTCAAGATTTTCAGCGAATGCCCATGTATTGCATGTATGAATGGAAATTATCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAC
AAGAATGGGATAAGGATATTCATCCATCTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	83.721	99.34	0.832
comR	Streptococcus pyogenes MGAS8232	56.291	99.67	0.561
comR	Streptococcus mutans UA159	45.819	98.68	0.452
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.575	96.37	0.449
comR	Streptococcus suis P1/7	37.288	97.36	0.363
comR	Streptococcus suis 05ZYH33	37.288	97.36	0.363