Detailed information NTG0600069

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: K6969_RS12310
• Genome accession: NZ_CP082205
• Coordinates: 2558831..2560027 (+)
• Length: 398 a.a.
• NCBI ID: WP_004195348.1
• Uniprot ID: A0A2I5KIT8
• Organism: Streptococcus suis strain AKJ18
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2553831..2565027

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6969_RS12280 (K6969_12150)	-	2554490..2557069 (+)	2580	WP_029173854.1	YfhO family protein	-
K6969_RS12300 (K6969_12170)	-	2557470..2558153 (-)	684	WP_171942918.1	YoaK family protein	-
K6969_RS12305 (K6969_12175)	rlmH	2558178..2558657 (-)	480	WP_023371894.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
K6969_RS12310 (K6969_12180)	htrA	2558831..2560027 (+)	1197	WP_004195348.1	S1C family serine protease	Regulator
K6969_RS12315 (K6969_12185)	spo0J	2560088..2560852 (+)	765	WP_171942917.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41758.83 Da
• Isoelectric Point: 4.5454

>NTDB_id=600069 K6969_RS12310 WP_004195348.1 2558831..2560027(+) (htrA) [Streptococcus suis strain AKJ18]
MERIPYMKKYLKFAILFVIGFLGGLIGALSASFFQPQIQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYVVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSEDGQTISTNAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKITSSSVSSSGVAVEGMGFAIPANDAVAIINQLEKAGKVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=600069 K6969_RS12310 WP_004195348.1 2558831..2560027(+) (htrA) [Streptococcus suis strain AKJ18]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTGGGTGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAACCACAGATTCAACAAGCAAATTCTGCTATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAGTCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCTGTTGCTGGAGAGGGGTCTGGGGTTAT
CTATAAAAAAGATGGTCAATATGCCTATGTTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATTCTTT
TAGCATCTGGAGAAAAAATCAGCGGTGAACTCGTTGGTTCCGATACCTATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCCAATACAGTTACTCAAGGTATTATTTCTAGCCTAAGTCGGACAGTTACTTCACAATCAGAAG
ATGGTCAAACAATCTCAACCAACGCTATTCAAACCGATACAGCTATCAACCCTGGAAACTCTGGAGGACCATTGATTAAT
ATCCAAGGACAAGTTATTGGTATCACCTCTAGCAAAATCACCTCAAGTTCTGTAAGTAGCTCAGGTGTGGCTGTGGAAGG
GATGGGATTCGCTATTCCTGCAAATGATGCCGTAGCCATTATCAATCAACTAGAGAAAGCTGGAAAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAGGCTGGATTATCAAATACAGAATTA
ACATCCGGTGTCGTAATTGTCTCTACACAAAGTGGACTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (293-389)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: A0A2I5KIT8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	60.453	99.749	0.603
htrA	Streptococcus gordonii str. Challis substr. CH1	60.506	99.246	0.6
htrA	Streptococcus pneumoniae Rx1	56.997	98.744	0.563
htrA	Streptococcus pneumoniae D39	56.997	98.744	0.563
htrA	Streptococcus pneumoniae R6	56.997	98.744	0.563
htrA	Streptococcus pneumoniae TIGR4	56.997	98.744	0.563
htrA	Streptococcus mitis NCTC 12261	56.997	98.744	0.563