NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	KX728_RS05680	Genome accession	NZ_CP079724
Coordinates	1147636..1148310 (-)	Length	224 a.a.
NCBI ID	WP_000590630.1	Uniprot ID	A0A4V0BT06
Organism	Streptococcus oralis strain 34
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1142636..1153310

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KX728_RS05655 (KX728_05650)	-	1142771..1143700 (-)	930	WP_084851842.1	peptidase U32 family protein	-
KX728_RS05660 (KX728_05655)	-	1143825..1144505 (-)	681	WP_215804590.1	ABC transporter ATP-binding protein	-
KX728_RS05665 (KX728_05660)	-	1144519..1145574 (-)	1056	WP_215804589.1	ABC transporter permease	-
KX728_RS05670 (KX728_05665)	-	1145960..1146244 (+)	285	WP_061414515.1	DUF3270 domain-containing protein	-
KX728_RS05675 (KX728_05670)	ciaH	1146309..1147646 (-)	1338	WP_215804588.1	cell wall metabolism sensor histidine kinase WalK	Regulator
KX728_RS05680 (KX728_05675)	ciaR	1147636..1148310 (-)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
KX728_RS05685 (KX728_05680)	-	1148417..1150963 (-)	2547	WP_215804587.1	M1 family metallopeptidase	-
KX728_RS05690 (KX728_05685)	-	1151085..1151525 (-)	441	WP_215804586.1	ASCH domain-containing protein	-
KX728_RS05695 (KX728_05690)	-	1151580..1151939 (-)	360	WP_215804585.1	hypothetical protein	-
KX728_RS05700 (KX728_05695)	-	1151917..1152417 (-)	501	WP_215804584.1	NUDIX hydrolase	-
KX728_RS05705 (KX728_05700)	-	1152428..1153126 (-)	699	WP_215804583.1	3-oxoacyl-ACP reductase	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25479.29 Da Isoelectric Point: 4.2660

                                >NTDB_id=588982 KX728_RS05680 WP_000590630.1 1147636..1148310(-) (ciaR) [Streptococcus oralis strain 34]

MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

Download Length: 675 bp

                                >NTDB_id=588982 KX728_RS05680 WP_000590630.1 1147636..1148310(-) (ciaR) [Streptococcus oralis strain 34]

ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT

CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTTGACTTGATGT

TGCCGGAAAAAAATGGTTTCCAAGTCTTGAAAGAGTTGCGCGAAAAAGGAATTACGACACCAGTCCTTATCATGACTGCC

AAAGAGAGTTTGGATGACAAGGGACACGGTTTTGAGCTTGGAGCGGATGACTACCTCACCAAACCTTTCTACCTTGAAGA

ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAACACCTTGACCTATGGAGATATTGTCG

TCAACCTTTCAACGAATGAAGTGAAAGTGGAAGATACTCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAC

TTCCTTCAAAATCAAAATGTTATTCTTCCCAAGACGCAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT

TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC

GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae TIGR4	97.768	100	0.978
ciaR	Streptococcus pneumoniae D39	97.768	100	0.978
ciaR	Streptococcus pneumoniae R6	97.768	100	0.978
ciaR	Streptococcus pneumoniae Rx1	97.768	100	0.978
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366

Detailed information NTG0588982