Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   KX728_RS05675 Genome accession   NZ_CP079724
Coordinates   1146309..1147646 (-) Length   445 a.a.
NCBI ID   WP_215804588.1    Uniprot ID   -
Organism   Streptococcus oralis strain 34     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1141309..1152646
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KX728_RS05650 (KX728_05645) rpiA 1141982..1142665 (-) 684 WP_061852182.1 ribose-5-phosphate isomerase RpiA -
  KX728_RS05655 (KX728_05650) - 1142771..1143700 (-) 930 WP_084851842.1 peptidase U32 family protein -
  KX728_RS05660 (KX728_05655) - 1143825..1144505 (-) 681 WP_215804590.1 ABC transporter ATP-binding protein -
  KX728_RS05665 (KX728_05660) - 1144519..1145574 (-) 1056 WP_215804589.1 ABC transporter permease -
  KX728_RS05670 (KX728_05665) - 1145960..1146244 (+) 285 WP_061414515.1 DUF3270 domain-containing protein -
  KX728_RS05675 (KX728_05670) ciaH 1146309..1147646 (-) 1338 WP_215804588.1 cell wall metabolism sensor histidine kinase WalK Regulator
  KX728_RS05680 (KX728_05675) ciaR 1147636..1148310 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  KX728_RS05685 (KX728_05680) - 1148417..1150963 (-) 2547 WP_215804587.1 M1 family metallopeptidase -
  KX728_RS05690 (KX728_05685) - 1151085..1151525 (-) 441 WP_215804586.1 ASCH domain-containing protein -
  KX728_RS05695 (KX728_05690) - 1151580..1151939 (-) 360 WP_215804585.1 hypothetical protein -
  KX728_RS05700 (KX728_05695) - 1151917..1152417 (-) 501 WP_215804584.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50802.49 Da        Isoelectric Point: 9.6085

>NTDB_id=588981 KX728_RS05675 WP_215804588.1 1146309..1147646(-) (ciaH) [Streptococcus oralis strain 34]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKVEIKPNVSSNTEVLLFDKDFNQLLLGNRFSGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANFELIASENDRIFEYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISAPDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=588981 KX728_RS05675 WP_215804588.1 1146309..1147646(-) (ciaH) [Streptococcus oralis strain 34]
ATGTTCAATAAACTAAAAAAAACATGGTATGCAGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCGATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTCCAAGCCC
TTAGTAGCAGTCCCCAAGCGGTTATCCAGTTAGCCTTGAATCGGGCAACTGAAGAGGTCAAGGATATTCAACCCGCAACT
GCGGATGCCAGCAAGGTTGAAATCAAACCCAATGTCAGCTCCAATACGGAAGTCTTACTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGGAATCGTTTTTCAGGTTTGGACAAGATCAAGTTGGACAAGAAAGAGTTGAATCACATTCGCCAAATCC
AAGTTGTCAATAGCTATGGTCAGGAAGAAACCTATCGGATGATTTTGATGGAAACCAACTCATCTTCCGTCTCAAGTAAC
GTCAAATATGCTGCGGTTTTAATCAATACCAGCCAGCTCGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTATTTGGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTCGAAAATGCCAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAA
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATTGCTTCGAGCCTTGAAGAAGTTCGCAACAT
GCGCTTTCTCACAACCAATCTTCTCAACCTTGCACGTCGCGATGATGGAATCAAACCAGAAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACTACCTTTGCTAACTTTGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTATTTGACAATGCCATCAAGTATACTGA
AGAAGATGGAAAAATTGAGTTTGTAGTTCATGCTACAGATCGTCATCTCTATCTAACAGTAACGGATAATGGAATTGGAA
TTTCAGCTCCTGACAAGAAGAAAATCTTTGACCGTTTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCTTTGGCCAAGCAGATCGTAGATGCCTTACGAGGAACGATTAGCGTCAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAAATCGCTATTCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

55.251

98.427

0.544