Detailed information NTG0058631

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: TL13_RS04325
• Genome accession: NC_021213
• Coordinates: 864852..865523 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis TL13
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 859852..870523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
TL13_RS04295 (TL13_0850)	pstC	860068..860985 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
TL13_RS04300 (TL13_0851)	pstA	860975..861862 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
TL13_RS04305 (TL13_0852)	pstB	861887..862690 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
TL13_RS04310 (TL13_0853)	pstB	862702..863460 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
TL13_RS04315 (TL13_0854)	phoU	863489..864145 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
TL13_RS04320 (TL13_0855)	-	864311..864658 (+)	348	WP_014635995.1	hypothetical protein	-
TL13_RS04325 (TL13_0856)	ciaR	864852..865523 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
TL13_RS04330 (TL13_0857)	ciaH	865516..866895 (+)	1380	WP_024409447.1	sensor histidine kinase	Regulator
TL13_RS04335 (TL13_0858)	-	866996..868225 (+)	1230	WP_014637854.1	transglutaminase domain-containing protein	-
TL13_RS04340 (TL13_0859)	rpsT	868488..868736 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
TL13_RS04345 (TL13_0860)	coaA	868795..869715 (-)	921	WP_002935283.1	type I pantothenate kinase	-
TL13_RS04350 (TL13_0861)	-	869824..870414 (+)	591	WP_014637855.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=58631 TL13_RS04325 WP_014637852.1 864852..865523(+) (ciaR) [Streptococcus suis TL13]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=58631 TL13_RS04325 WP_014637852.1 864852..865523(+) (ciaR) [Streptococcus suis TL13]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368