Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   I872_RS08770 Genome accession   NC_021175
Coordinates   1773413..1775566 (-) Length   717 a.a.
NCBI ID   WP_015605745.1    Uniprot ID   A0A512ADD9
Organism   Streptococcus cristatus AS 1.3089     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1768413..1780566
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I872_RS08745 (I872_08765) - 1768713..1769240 (+) 528 WP_015605740.1 NUDIX hydrolase -
  I872_RS08750 (I872_08770) - 1769353..1770504 (-) 1152 WP_015605741.1 FtsX-like permease family protein -
  I872_RS08755 (I872_08775) - 1770508..1771188 (-) 681 WP_015605742.1 ABC transporter ATP-binding protein -
  I872_RS08760 (I872_08780) - 1771185..1771763 (-) 579 WP_015605743.1 TetR/AcrR family transcriptional regulator -
  I872_RS08765 (I872_08785) comB 1772043..1773398 (-) 1356 WP_015605744.1 bacteriocin secretion accessory protein Regulator
  I872_RS08770 (I872_08790) comA 1773413..1775566 (-) 2154 WP_015605745.1 peptide cleavage/export ABC transporter ComA Regulator
  I872_RS08775 (I872_08795) - 1775922..1776149 (-) 228 WP_231913924.1 hypothetical protein -
  I872_RS08780 - 1776218..1776391 (-) 174 WP_041826837.1 Blp family class II bacteriocin -
  I872_RS08785 (I872_08800) rnhC 1776616..1777500 (+) 885 WP_015605747.1 ribonuclease HIII -
  I872_RS08790 (I872_08805) lepB 1777504..1778136 (+) 633 WP_015605748.1 signal peptidase I -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 81109.54 Da        Isoelectric Point: 8.4090

>NTDB_id=58476 I872_RS08770 WP_015605745.1 1773413..1775566(-) (comA) [Streptococcus cristatus AS 1.3089]
MRFTKRHYRAQVDARDCGVAALAMIYGYYGSYYSLASLREMAKTTLRGTTAFGLVKVSEELGFETRALKADMSLFDMKGV
IYPFIAHVIKDKKMLHYYVVTGHDKHSVHIADPDPAVKMTKLSKEQFAQEWTGVSIFIAPAPEYRPHKEKKNGLWSFVPI
LIKQKGLIANIVIATMLVTIINIVGSYYMQGIIDTYVPNQMRNTLGIISLGLIVVYILQQILSYAQNYLLLILGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFNDANSIIDALASTILSIFLDVSIVVVMAVVLFSQNFYLFFISLLSLPIYIV
VIFAFMKPFEKMNRDTMESNAILSSSIIEDINGIETIKSLTSEDFRYQKIDREFVDYLKKSFAYSRMENIQIGLKKTAQL
LLNVAILWMGALLVMDNKMTLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVDSEFMDKKAIRDLSMT
KGNIELRNVSYKYGYGRNVLSDINLTIERGSKVAFVGISGSGKTTLAKMIVNFYDPNEGEILVNNINLNQIDKHVLRRHI
NYLPQQPYVFNGTILENVLLGAKPGTTQKEIIRALEIAEIREDIERMPLNYQTELTSDGSGISGGQRQRLALARALLTDA
PVLILDEATSNLDILTEKKIIDNLLELDKTIIFIAHRLTIAERSEKVVVLDKGEIVEQGTHEELVAQDGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=58476 I872_RS08770 WP_015605745.1 1773413..1775566(-) (comA) [Streptococcus cristatus AS 1.3089]
ATGAGATTTACAAAGCGTCATTATAGAGCTCAAGTTGACGCTAGAGATTGTGGTGTAGCAGCGCTCGCCATGATTTATGG
TTATTATGGTTCCTATTATTCTTTGGCCAGTTTGCGTGAAATGGCCAAAACGACCTTGAGGGGAACAACTGCTTTTGGGC
TAGTGAAAGTTTCGGAAGAGTTAGGCTTTGAGACACGAGCCTTGAAAGCGGATATGTCTTTATTTGACATGAAAGGGGTT
ATCTATCCTTTTATCGCTCATGTCATCAAAGACAAGAAGATGCTTCATTACTACGTTGTGACTGGGCATGATAAACATTC
GGTTCATATTGCTGACCCTGATCCAGCTGTTAAGATGACCAAGCTTTCTAAGGAACAGTTTGCGCAAGAGTGGACAGGTG
TTTCTATTTTCATTGCCCCCGCACCGGAATATAGACCGCACAAGGAAAAGAAAAATGGTCTCTGGTCTTTTGTTCCAATT
TTAATAAAGCAAAAAGGCTTGATTGCTAATATCGTTATCGCAACGATGCTGGTTACGATCATCAATATCGTGGGCTCTTA
CTATATGCAGGGGATTATTGATACCTATGTACCCAATCAGATGAGGAATACCTTAGGGATTATTTCTTTGGGTCTAATAG
TCGTCTATATTCTGCAACAGATCCTATCCTATGCCCAGAATTATTTGCTTCTCATTTTGGGACAACGACTTTCGATTGAT
GTGATTTTATCCTATATCAAGCATGTCTTTCATCTACCTATGTCCTTTTTCGCTACGAGAAGGACAGGGGAAATCGTATC
GCGCTTCAATGATGCCAATAGTATCATCGACGCCTTGGCTAGTACCATTCTCTCCATCTTCTTGGATGTCTCCATCGTTG
TCGTCATGGCAGTTGTTTTGTTCTCGCAAAACTTCTATTTATTCTTTATCAGCTTGCTCTCGCTGCCGATCTATATTGTC
GTGATTTTTGCCTTCATGAAACCATTTGAAAAAATGAATCGTGACACCATGGAATCCAATGCCATTCTGTCTTCTTCCAT
TATCGAGGATATCAATGGGATTGAGACGATCAAATCCTTGACCAGTGAGGATTTCCGCTATCAAAAGATTGATAGAGAAT
TTGTGGATTATTTGAAGAAATCATTTGCTTATAGTCGGATGGAGAATATCCAAATTGGTTTGAAGAAGACAGCTCAGCTC
TTGCTGAATGTTGCAATCCTTTGGATGGGAGCCCTCTTGGTTATGGACAATAAAATGACCTTGGGGCAGCTGATTACTTA
TAACACTTTGCTGGTTTATTTCACGAATCCGCTGGAAAACATTATCAATTTACAGACCAAACTCCAAACAGCGCAAGTTG
CCAATAATCGTTTGAATGAGGTTTATTTGGTTGATTCTGAGTTTATGGATAAAAAAGCGATTCGTGATTTGAGTATGACC
AAGGGCAATATTGAGTTGCGGAATGTTAGCTATAAGTATGGCTATGGACGAAATGTCCTGTCAGATATTAACTTGACCAT
TGAAAGAGGCAGTAAGGTGGCCTTTGTCGGAATTTCTGGTTCTGGAAAGACGACCCTTGCTAAGATGATTGTGAATTTCT
ATGATCCGAACGAGGGAGAGATTCTGGTTAATAATATCAACCTCAATCAGATTGACAAACATGTCTTGCGGCGTCATATC
AATTACTTGCCACAACAGCCTTATGTTTTTAATGGTACCATCTTGGAGAATGTTCTCCTAGGTGCCAAGCCTGGAACGAC
TCAGAAAGAGATCATTCGAGCGCTGGAAATTGCCGAGATTCGTGAAGACATTGAACGGATGCCTTTGAATTATCAAACAG
AATTGACATCAGATGGTTCAGGGATTTCAGGTGGTCAGCGTCAGCGTTTGGCCTTAGCTCGGGCTCTTTTGACCGATGCT
CCTGTTTTGATTCTCGATGAGGCGACCAGCAACCTTGATATCTTGACAGAGAAAAAGATTATTGACAACCTTTTAGAGTT
GGACAAGACCATTATATTCATTGCCCATCGACTGACCATTGCAGAGCGATCTGAAAAAGTGGTCGTCCTGGACAAGGGCG
AAATCGTAGAGCAAGGAACGCATGAGGAGCTGGTTGCTCAAGATGGCTTCTATGCTCATCTGGTAAATAGTTAG

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(170-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A512ADD9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

79.777

100

0.798
  comA Streptococcus mitis SK321

79.498

100

0.795
  comA Streptococcus pneumoniae Rx1

79.498

100

0.795
  comA Streptococcus pneumoniae D39

79.498

100

0.795
  comA Streptococcus pneumoniae R6

79.498

100

0.795
  comA Streptococcus pneumoniae TIGR4

79.219

100

0.792
  comA Streptococcus gordonii str. Challis substr. CH1

76.29

100

0.763
  comA/nlmT Streptococcus mutans UA159

63.459

100

0.635

Multiple sequence alignment