Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   I872_RS08765 Genome accession   NC_021175
Coordinates   1772043..1773398 (-) Length   451 a.a.
NCBI ID   WP_015605744.1    Uniprot ID   A0A512AD83
Organism   Streptococcus cristatus AS 1.3089     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1767043..1778398
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I872_RS08735 (I872_08755) - 1767091..1767852 (-) 762 WP_015605738.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
  I872_RS08740 (I872_08760) truA 1767842..1768591 (-) 750 WP_015605739.1 tRNA pseudouridine(38-40) synthase TruA -
  I872_RS08745 (I872_08765) - 1768713..1769240 (+) 528 WP_015605740.1 NUDIX hydrolase -
  I872_RS08750 (I872_08770) - 1769353..1770504 (-) 1152 WP_015605741.1 FtsX-like permease family protein -
  I872_RS08755 (I872_08775) - 1770508..1771188 (-) 681 WP_015605742.1 ABC transporter ATP-binding protein -
  I872_RS08760 (I872_08780) - 1771185..1771763 (-) 579 WP_015605743.1 TetR/AcrR family transcriptional regulator -
  I872_RS08765 (I872_08785) comB 1772043..1773398 (-) 1356 WP_015605744.1 bacteriocin secretion accessory protein Regulator
  I872_RS08770 (I872_08790) comA 1773413..1775566 (-) 2154 WP_015605745.1 peptide cleavage/export ABC transporter ComA Regulator
  I872_RS08775 (I872_08795) - 1775922..1776149 (-) 228 WP_231913924.1 hypothetical protein -
  I872_RS08780 - 1776218..1776391 (-) 174 WP_041826837.1 Blp family class II bacteriocin -
  I872_RS08785 (I872_08800) rnhC 1776616..1777500 (+) 885 WP_015605747.1 ribonuclease HIII -
  I872_RS08790 (I872_08805) lepB 1777504..1778136 (+) 633 WP_015605748.1 signal peptidase I -

Sequence

Protein


Download         Length: 451 a.a.        Molecular weight: 49930.89 Da        Isoelectric Point: 6.3250

>NTDB_id=58475 I872_RS08765 WP_015605744.1 1772043..1773398(-) (comB) [Streptococcus cristatus AS 1.3089]
MKEHYLESAEFYNRRYSSFSVHVILPTFFLLLFVVLFSLFAKKEITITSGASIEPSKILASIQSTSNNAIVTNNLKENKV
VKKGDLLVQYKSDSENTQKETFSSQVESLKEQKRQLELLQESLKTGTSQFSGEDRFGYEQAFNDYKSQAASIRSNTEQQN
STIASQNSAASNSQAELGNLINETNAKLADYQTLRNAIQNGTSVPSTNAGYSIYQAYEAQAVADSQGQLKSQVLSQIDNQ
ISQFESALSGYRVQYAGSGAQQAYSGSLDSQLESLKAQQLTKVGQELTALNQKILEVENNLKVQGGITQKGMITATEDGI
LHLNPETAGANLVPEGKLLAQLYPVLTKEKKVIITTYVTSKDVASLKKGETLRFTAMDENNKEFVLKSKISNIDSNATKT
EKGNFFKVEAETTLTDAQAKKMRYGVEGRAVVITGSKTYFDYYLDEFLRRD

Nucleotide


Download         Length: 1356 bp        

>NTDB_id=58475 I872_RS08765 WP_015605744.1 1772043..1773398(-) (comB) [Streptococcus cristatus AS 1.3089]
ATGAAAGAACATTACTTAGAGAGTGCCGAATTTTATAATCGTAGATATTCTAGCTTTTCTGTGCACGTGATTTTACCGAC
TTTCTTCTTATTGCTTTTTGTAGTTTTATTCTCTCTATTTGCTAAAAAAGAAATCACCATTACTTCAGGTGCCTCTATTG
AGCCTAGCAAAATTTTGGCCAGCATCCAATCAACTAGTAACAATGCTATTGTTACTAATAACTTAAAGGAAAACAAGGTT
GTTAAAAAAGGGGATCTTTTAGTTCAGTATAAGTCTGATAGCGAAAATACTCAGAAAGAAACCTTCTCCTCTCAAGTGGA
AAGCTTGAAGGAGCAAAAACGGCAGTTGGAATTGCTACAAGAAAGTCTGAAGACGGGGACTAGCCAGTTTTCAGGAGAGG
ATCGCTTCGGTTATGAGCAGGCCTTTAATGACTATAAGAGTCAAGCTGCTAGCATCCGTAGCAACACCGAACAACAGAAT
TCGACCATTGCTTCTCAAAATTCAGCGGCTAGCAATTCACAGGCAGAGCTGGGAAATTTGATCAATGAAACCAATGCTAA
ATTGGCGGATTATCAAACGCTTAGAAACGCCATCCAAAATGGGACAAGTGTCCCTTCGACCAATGCTGGTTATAGCATTT
ATCAGGCTTATGAGGCGCAAGCCGTTGCTGATAGTCAAGGTCAGCTAAAGAGTCAAGTTCTGTCGCAGATTGACAATCAG
ATTTCGCAGTTTGAATCAGCTCTTTCGGGTTATCGGGTGCAGTATGCAGGTTCCGGTGCTCAGCAAGCCTATTCTGGAAG
TTTGGATAGCCAGCTTGAATCCTTGAAAGCTCAACAATTGACTAAAGTTGGCCAAGAGTTGACGGCCTTGAATCAAAAGA
TTTTAGAAGTTGAAAACAATCTCAAGGTGCAAGGTGGTATTACTCAAAAGGGCATGATCACAGCAACTGAAGATGGTATT
CTCCACCTAAATCCTGAAACAGCAGGAGCGAATTTGGTTCCCGAAGGGAAGTTGCTCGCTCAGTTGTATCCTGTTTTGAC
CAAGGAAAAAAAGGTGATTATCACCACTTATGTGACCTCAAAAGATGTTGCTAGTCTGAAAAAAGGTGAAACTCTACGTT
TCACTGCAATGGACGAAAATAATAAAGAGTTTGTTCTCAAATCTAAAATTTCGAACATTGATAGCAATGCAACAAAGACG
GAAAAAGGAAACTTCTTTAAAGTGGAAGCTGAAACAACCTTAACCGATGCTCAGGCCAAGAAAATGCGTTATGGTGTTGA
AGGTCGTGCGGTTGTCATCACAGGAAGCAAGACCTACTTTGACTATTACTTGGATGAATTCTTAAGAAGAGATTAA

Domains

Predicted by InterproScan.

HlyD family secretion protein (HlyD_3)

(313-425)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A512AD83

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae R6

57.206

100

0.572
  comB Streptococcus pneumoniae Rx1

57.206

100

0.572
  comB Streptococcus pneumoniae D39

57.206

100

0.572
  comB Streptococcus mitis SK321

57.206

100

0.572
  comB Streptococcus mitis NCTC 12261

56.984

100

0.57
  comB Streptococcus pneumoniae TIGR4

56.763

100

0.568
  comB Streptococcus gordonii str. Challis substr. CH1

53.898

99.557

0.537

Multiple sequence alignment