Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   I6L85_RS00395 Genome accession   NZ_CP077248
Coordinates   58463..59821 (+) Length   452 a.a.
NCBI ID   WP_111724244.1    Uniprot ID   -
Organism   Streptococcus gordonii strain FDAARGOS 1455     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 24721..61589 58463..59821 within 0


Gene organization within MGE regions


Location: 24721..61589
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L85_RS00135 (I6L85_00135) ftsH 24721..26703 (+) 1983 WP_046164766.1 ATP-dependent zinc metalloprotease FtsH -
  I6L85_RS00150 (I6L85_00150) comR/comR2 27232..27714 (+) 483 WP_045772576.1 sigma-70 family RNA polymerase sigma factor Regulator
  I6L85_RS00260 (I6L85_00260) mreC 34619..35434 (+) 816 WP_111724262.1 rod shape-determining protein MreC -
  I6L85_RS00265 (I6L85_00265) mreD 35436..35936 (+) 501 WP_111724261.1 rod shape-determining protein MreD -
  I6L85_RS00270 (I6L85_00270) pcsB 36036..37226 (+) 1191 WP_111724260.1 peptidoglycan hydrolase PcsB -
  I6L85_RS00275 (I6L85_00275) - 37386..38351 (+) 966 WP_111724259.1 ribose-phosphate diphosphokinase -
  I6L85_RS00280 (I6L85_00280) abpA 38568..39155 (+) 588 WP_045504766.1 amylase-binding adhesin AbpA -
  I6L85_RS00285 (I6L85_00285) srtB 39243..40100 (+) 858 WP_045504765.1 class B sortase, LPKTxAVK-specific -
  I6L85_RS00290 (I6L85_00290) - 40179..40838 (+) 660 WP_061597425.1 HAD family phosphatase -
  I6L85_RS00295 (I6L85_00295) - 41178..41468 (+) 291 WP_045504760.1 thiamine-binding protein -
  I6L85_RS00300 (I6L85_00300) - 41431..42183 (+) 753 WP_060554273.1 ABC transporter permease -
  I6L85_RS00305 (I6L85_00305) - 42224..43225 (+) 1002 WP_111724258.1 ABC transporter substrate-binding protein -
  I6L85_RS00310 (I6L85_00310) - 43225..43947 (+) 723 WP_111724257.1 ABC transporter ATP-binding protein -
  I6L85_RS00315 (I6L85_00315) rpsD 44213..44824 (+) 612 WP_008810013.1 30S ribosomal protein S4 -
  I6L85_RS00320 (I6L85_00320) - 44913..46079 (-) 1167 WP_111724256.1 site-specific integrase -
  I6L85_RS00325 (I6L85_00325) - 46425..47414 (-) 990 WP_084849558.1 DUF3644 domain-containing protein -
  I6L85_RS00330 (I6L85_00330) - 47458..48231 (-) 774 WP_111724255.1 helix-turn-helix transcriptional regulator -
  I6L85_RS00335 (I6L85_00335) - 48395..48592 (+) 198 WP_111724254.1 helix-turn-helix transcriptional regulator -
  I6L85_RS00340 (I6L85_00340) - 48607..49233 (+) 627 WP_111724253.1 Rha family transcriptional regulator -
  I6L85_RS00345 (I6L85_00345) - 49515..49718 (+) 204 WP_111724252.1 hypothetical protein -
  I6L85_RS00350 (I6L85_00350) - 49720..49935 (+) 216 WP_111724251.1 hypothetical protein -
  I6L85_RS00355 (I6L85_00355) - 49932..50273 (+) 342 WP_111724250.1 DNA-binding protein -
  I6L85_RS00360 (I6L85_00360) - 50266..50542 (+) 277 Protein_45 XRE family transcriptional regulator -
  I6L85_RS00365 (I6L85_00365) - 50683..51543 (+) 861 WP_111724249.1 primase alpha helix C-terminal domain-containing protein -
  I6L85_RS00370 (I6L85_00370) - 51623..53062 (+) 1440 WP_111724323.1 phage/plasmid primase, P4 family -
  I6L85_RS00375 (I6L85_00375) - 53427..53951 (+) 525 WP_111724248.1 hypothetical protein -
  I6L85_RS00380 (I6L85_00380) - 54024..54527 (+) 504 WP_111724247.1 hypothetical protein -
  I6L85_RS00385 (I6L85_00385) - 55389..55598 (+) 210 WP_111724246.1 hypothetical protein -
  I6L85_RS00390 (I6L85_00390) comA 56300..58453 (+) 2154 WP_111724245.1 peptide cleavage/export ABC transporter ComA Regulator
  I6L85_RS00395 (I6L85_00395) comB 58463..59821 (+) 1359 WP_111724244.1 competence pheromone export protein ComB Regulator
  I6L85_RS00400 (I6L85_00400) lytF 59940..61589 (-) 1650 WP_111724243.1 GBS Bsp-like repeat-containing protein Regulator

Sequence

Protein


Download         Length: 452 a.a.        Molecular weight: 49835.12 Da        Isoelectric Point: 6.1758

>NTDB_id=580233 I6L85_RS00395 WP_111724244.1 58463..59821(+) (comB) [Streptococcus gordonii strain FDAARGOS 1455]
MNEQFLESAEFYQKRYHNFASCLIVPSLILLVFLVGFSMLAKKEITISSRASVEASRVLAQIQSTSNQAIIANHLAENKE
VKKGDLLIQYAVEGEGAQEQKFSSQLDLLKDQKGKLETLRSSLESGRNQFTEPDSYGYEQSFKDYQNQVASMTSSVNQQN
ATIASQNAAASQSQAELGGVISDVDSKLNDYRNLKNAIQSGVGIDASHPLYSLYQSYRDQLSLAEDKTTAQSQIVAQLDG
QISQLEATAATYRVQYAGAGAQQAYASNLSSQLASLKAQYLVKVGQELTTLTQQILEAESNLKLQETVSKRGQILAEMDG
LLHLNPEVQGSTLVAEGTALAQIYPKITSERKIKIVTYVSSKDVSTIKNGDKVRFITADDANKQMILTSQISSIDANATQ
TKQGNFFKVECEMAVSKDQAKKLRYGLEGKFVMVTGQKTYFSYYMEKFFNLG

Nucleotide


Download         Length: 1359 bp        

>NTDB_id=580233 I6L85_RS00395 WP_111724244.1 58463..59821(+) (comB) [Streptococcus gordonii strain FDAARGOS 1455]
ATGAATGAACAATTTTTAGAAAGTGCAGAGTTTTATCAGAAACGTTATCATAATTTTGCTAGTTGTTTAATTGTGCCAAG
TCTTATTTTACTAGTATTTCTAGTTGGTTTTTCCATGCTGGCTAAAAAGGAAATTACGATTTCTAGCCGTGCTTCTGTAG
AAGCTAGCCGAGTGCTAGCTCAGATTCAGTCGACTAGTAACCAGGCTATCATTGCGAATCATTTGGCAGAAAATAAGGAG
GTCAAAAAAGGAGACCTGTTAATTCAGTATGCAGTAGAAGGAGAGGGAGCTCAGGAACAGAAGTTTTCCAGCCAGCTTGA
CTTACTCAAAGATCAAAAGGGCAAACTAGAAACTTTGCGTTCCAGTTTAGAAAGCGGGCGTAATCAATTCACTGAGCCAG
ATAGTTATGGCTACGAACAAAGCTTTAAAGACTACCAGAATCAAGTAGCGAGTATGACTAGTTCTGTGAATCAGCAAAAT
GCTACGATTGCTTCACAAAATGCAGCGGCCAGTCAGTCTCAGGCGGAACTGGGCGGTGTTATCAGTGATGTGGATAGCAA
ACTAAATGACTATCGAAACTTGAAAAATGCCATTCAAAGTGGGGTAGGTATAGACGCATCGCACCCTCTTTACTCCTTGT
ATCAGTCCTATCGTGATCAGTTGAGTTTGGCAGAGGATAAGACTACGGCTCAAAGTCAGATTGTAGCTCAATTAGATGGG
CAAATTTCTCAATTAGAAGCAACAGCTGCGACTTATCGTGTCCAATATGCTGGTGCAGGCGCTCAACAAGCCTATGCTAG
CAATTTATCTAGTCAGTTGGCTTCACTGAAAGCTCAGTATCTGGTCAAGGTAGGACAAGAATTGACCACTCTGACTCAGC
AAATCTTGGAAGCCGAGAGCAATCTTAAACTTCAAGAAACAGTCTCTAAGCGAGGTCAGATTTTGGCTGAAATGGATGGC
TTGCTTCACTTAAATCCAGAAGTACAAGGATCTACTCTAGTGGCAGAAGGAACAGCTTTGGCTCAGATTTATCCTAAAAT
CACCAGTGAACGAAAAATCAAAATTGTCACATATGTCTCTTCCAAGGATGTATCTACTATTAAAAATGGAGATAAGGTGC
GCTTTATCACAGCTGATGATGCTAACAAACAAATGATTTTGACATCCCAAATTTCCAGTATTGACGCCAATGCTACTCAA
ACCAAACAAGGAAATTTCTTTAAAGTAGAATGCGAAATGGCTGTTAGTAAAGATCAAGCTAAGAAGCTCCGCTATGGCTT
GGAAGGTAAATTCGTCATGGTAACTGGGCAAAAGACTTATTTCAGCTATTATATGGAGAAGTTTTTTAATCTTGGTTGA

Domains

Predicted by InterproScan.

HlyD family secretion protein (HlyD_3)

(314-426)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus gordonii str. Challis substr. CH1

98.23

100

0.982
  comB Streptococcus pneumoniae Rx1

56.222

99.558

0.56
  comB Streptococcus pneumoniae D39

56.222

99.558

0.56
  comB Streptococcus pneumoniae R6

56.222

99.558

0.56
  comB Streptococcus mitis NCTC 12261

56

99.558

0.558
  comB Streptococcus pneumoniae TIGR4

55.778

99.558

0.555
  comB Streptococcus mitis SK321

55.333

99.558

0.551