Detailed information
Bioinformatically predicted
Overview
| Name | comA | Type | Regulator |
| Locus tag | I6L85_RS00390 | Genome accession | NZ_CP077248 |
| Coordinates | 56300..58453 (+) | Length | 717 a.a. |
| NCBI ID | WP_111724245.1 | Uniprot ID | - |
| Organism | Streptococcus gordonii strain FDAARGOS 1455 | ||
| Function | processing and transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 24721..61589 | 56300..58453 | within | 0 |
Gene organization within MGE regions
Location: 24721..61589
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L85_RS00135 (I6L85_00135) | ftsH | 24721..26703 (+) | 1983 | WP_046164766.1 | ATP-dependent zinc metalloprotease FtsH | - |
| I6L85_RS00150 (I6L85_00150) | comR/comR2 | 27232..27714 (+) | 483 | WP_045772576.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| I6L85_RS00260 (I6L85_00260) | mreC | 34619..35434 (+) | 816 | WP_111724262.1 | rod shape-determining protein MreC | - |
| I6L85_RS00265 (I6L85_00265) | mreD | 35436..35936 (+) | 501 | WP_111724261.1 | rod shape-determining protein MreD | - |
| I6L85_RS00270 (I6L85_00270) | pcsB | 36036..37226 (+) | 1191 | WP_111724260.1 | peptidoglycan hydrolase PcsB | - |
| I6L85_RS00275 (I6L85_00275) | - | 37386..38351 (+) | 966 | WP_111724259.1 | ribose-phosphate diphosphokinase | - |
| I6L85_RS00280 (I6L85_00280) | abpA | 38568..39155 (+) | 588 | WP_045504766.1 | amylase-binding adhesin AbpA | - |
| I6L85_RS00285 (I6L85_00285) | srtB | 39243..40100 (+) | 858 | WP_045504765.1 | class B sortase, LPKTxAVK-specific | - |
| I6L85_RS00290 (I6L85_00290) | - | 40179..40838 (+) | 660 | WP_061597425.1 | HAD family phosphatase | - |
| I6L85_RS00295 (I6L85_00295) | - | 41178..41468 (+) | 291 | WP_045504760.1 | thiamine-binding protein | - |
| I6L85_RS00300 (I6L85_00300) | - | 41431..42183 (+) | 753 | WP_060554273.1 | ABC transporter permease | - |
| I6L85_RS00305 (I6L85_00305) | - | 42224..43225 (+) | 1002 | WP_111724258.1 | ABC transporter substrate-binding protein | - |
| I6L85_RS00310 (I6L85_00310) | - | 43225..43947 (+) | 723 | WP_111724257.1 | ABC transporter ATP-binding protein | - |
| I6L85_RS00315 (I6L85_00315) | rpsD | 44213..44824 (+) | 612 | WP_008810013.1 | 30S ribosomal protein S4 | - |
| I6L85_RS00320 (I6L85_00320) | - | 44913..46079 (-) | 1167 | WP_111724256.1 | site-specific integrase | - |
| I6L85_RS00325 (I6L85_00325) | - | 46425..47414 (-) | 990 | WP_084849558.1 | DUF3644 domain-containing protein | - |
| I6L85_RS00330 (I6L85_00330) | - | 47458..48231 (-) | 774 | WP_111724255.1 | helix-turn-helix transcriptional regulator | - |
| I6L85_RS00335 (I6L85_00335) | - | 48395..48592 (+) | 198 | WP_111724254.1 | helix-turn-helix transcriptional regulator | - |
| I6L85_RS00340 (I6L85_00340) | - | 48607..49233 (+) | 627 | WP_111724253.1 | Rha family transcriptional regulator | - |
| I6L85_RS00345 (I6L85_00345) | - | 49515..49718 (+) | 204 | WP_111724252.1 | hypothetical protein | - |
| I6L85_RS00350 (I6L85_00350) | - | 49720..49935 (+) | 216 | WP_111724251.1 | hypothetical protein | - |
| I6L85_RS00355 (I6L85_00355) | - | 49932..50273 (+) | 342 | WP_111724250.1 | DNA-binding protein | - |
| I6L85_RS00360 (I6L85_00360) | - | 50266..50542 (+) | 277 | Protein_45 | XRE family transcriptional regulator | - |
| I6L85_RS00365 (I6L85_00365) | - | 50683..51543 (+) | 861 | WP_111724249.1 | primase alpha helix C-terminal domain-containing protein | - |
| I6L85_RS00370 (I6L85_00370) | - | 51623..53062 (+) | 1440 | WP_111724323.1 | phage/plasmid primase, P4 family | - |
| I6L85_RS00375 (I6L85_00375) | - | 53427..53951 (+) | 525 | WP_111724248.1 | hypothetical protein | - |
| I6L85_RS00380 (I6L85_00380) | - | 54024..54527 (+) | 504 | WP_111724247.1 | hypothetical protein | - |
| I6L85_RS00385 (I6L85_00385) | - | 55389..55598 (+) | 210 | WP_111724246.1 | hypothetical protein | - |
| I6L85_RS00390 (I6L85_00390) | comA | 56300..58453 (+) | 2154 | WP_111724245.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| I6L85_RS00395 (I6L85_00395) | comB | 58463..59821 (+) | 1359 | WP_111724244.1 | competence pheromone export protein ComB | Regulator |
| I6L85_RS00400 (I6L85_00400) | lytF | 59940..61589 (-) | 1650 | WP_111724243.1 | GBS Bsp-like repeat-containing protein | Regulator |
Sequence
Protein
Download Length: 717 a.a. Molecular weight: 80754.75 Da Isoelectric Point: 7.0816
>NTDB_id=580232 I6L85_RS00390 WP_111724245.1 56300..58453(+) (comA) [Streptococcus gordonii strain FDAARGOS 1455]
MKFRKRHYRAQVDTRDCGVAALAMVFGYYGSYFSLATLREKAKTTNDGTTALGLVKVAEGLNFETRAFKADMGIFDLEYV
SYPFIVHVLKEGKLLHYYVVTGQDKHTIHIADPDPQVKMTKISRERFEQEWTGITIFLAPSPAYKPSQEKKNGLLDFIPL
LIKQKGLITNIVLATLLVTVINIVGSYYLQSIIDTYVPDHMKTTLGMISIGLIIVYILQQFLSYAQEYLLLVLGQRLSID
VILSYIKHVFQLPMSFFATRRTGEIVSRFTDANRIIDALASTILSIFLDVSIVSIIAIVLFSQNSSLFFLTLLGIPVYAL
IIFLFMKPFEKMNHETMEANSLLSSSIIEDINGIETIKSLTSEKQRYQKIDKEFVTYLKKSFAYGRSESLQKVLKAAARL
ILNVLILWLGATLVMDQKISLGQLITYNTLLVYFTNPLENIINLQTKLQSARVANERLNEVYLVQSEFEEEKLIKDLSHF
QADIDFRGVSYKYGYGANVLSEIDLHIPAGSKTSFVGVSGSGKTTLAKMMVHFYAPNHGDICLGGVNLNQLDKQALRQYI
NYLPQQPYVFNGTILENLLLGAREGTTQEDILRAVELAEIRSDIERMPLNYQTELSADGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIIDNLMALDKTIIFIAHRLTIAERSEQVVVLDQGRIVESGSHKELIEREGFYHHLVNS
MKFRKRHYRAQVDTRDCGVAALAMVFGYYGSYFSLATLREKAKTTNDGTTALGLVKVAEGLNFETRAFKADMGIFDLEYV
SYPFIVHVLKEGKLLHYYVVTGQDKHTIHIADPDPQVKMTKISRERFEQEWTGITIFLAPSPAYKPSQEKKNGLLDFIPL
LIKQKGLITNIVLATLLVTVINIVGSYYLQSIIDTYVPDHMKTTLGMISIGLIIVYILQQFLSYAQEYLLLVLGQRLSID
VILSYIKHVFQLPMSFFATRRTGEIVSRFTDANRIIDALASTILSIFLDVSIVSIIAIVLFSQNSSLFFLTLLGIPVYAL
IIFLFMKPFEKMNHETMEANSLLSSSIIEDINGIETIKSLTSEKQRYQKIDKEFVTYLKKSFAYGRSESLQKVLKAAARL
ILNVLILWLGATLVMDQKISLGQLITYNTLLVYFTNPLENIINLQTKLQSARVANERLNEVYLVQSEFEEEKLIKDLSHF
QADIDFRGVSYKYGYGANVLSEIDLHIPAGSKTSFVGVSGSGKTTLAKMMVHFYAPNHGDICLGGVNLNQLDKQALRQYI
NYLPQQPYVFNGTILENLLLGAREGTTQEDILRAVELAEIRSDIERMPLNYQTELSADGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIIDNLMALDKTIIFIAHRLTIAERSEQVVVLDQGRIVESGSHKELIEREGFYHHLVNS
Nucleotide
Download Length: 2154 bp
>NTDB_id=580232 I6L85_RS00390 WP_111724245.1 56300..58453(+) (comA) [Streptococcus gordonii strain FDAARGOS 1455]
ATGAAATTTAGGAAACGGCATTACAGAGCGCAAGTTGATACTAGGGATTGCGGTGTGGCAGCTCTGGCTATGGTTTTTGG
TTATTATGGATCGTATTTTTCCTTAGCTACACTGCGAGAAAAGGCAAAAACTACCAATGATGGCACAACTGCTTTGGGTT
TGGTAAAAGTTGCTGAGGGTCTAAATTTTGAGACAAGGGCTTTTAAAGCTGATATGGGAATCTTTGATCTGGAATATGTA
TCTTATCCTTTCATCGTTCATGTACTTAAGGAAGGGAAGCTCCTGCATTATTATGTTGTGACGGGACAAGATAAACACAC
GATTCATATTGCAGACCCAGACCCTCAAGTTAAGATGACAAAGATTTCGCGAGAGCGTTTTGAACAGGAGTGGACAGGAA
TTACCATTTTCCTAGCTCCTAGTCCAGCCTATAAGCCTAGTCAGGAAAAGAAGAATGGGCTTTTGGACTTCATTCCCTTA
TTGATCAAGCAAAAGGGGTTGATTACTAATATTGTGCTTGCAACTTTGCTGGTAACAGTGATTAATATTGTTGGATCTTA
CTACCTTCAGTCGATTATTGATACTTATGTGCCTGATCATATGAAAACGACGCTGGGTATGATTTCTATCGGCTTGATTA
TTGTCTATATTTTGCAGCAATTCTTGTCTTATGCCCAAGAATATTTGCTTTTGGTTTTAGGGCAGCGCCTATCGATTGAT
GTGATCTTATCCTATATTAAGCATGTTTTTCAGCTACCTATGTCATTTTTTGCGACAAGGCGGACAGGAGAAATCGTCTC
TCGTTTTACAGATGCCAATAGAATTATTGATGCTTTGGCCAGTACAATCTTGTCTATTTTCTTGGATGTATCGATTGTGT
CGATCATTGCGATTGTTCTTTTTTCACAAAATAGCAGTCTTTTCTTTTTGACCTTGTTAGGAATCCCAGTTTACGCTCTC
ATTATTTTTCTTTTTATGAAGCCTTTTGAAAAGATGAATCATGAGACGATGGAAGCAAATAGTTTGTTGTCGTCTTCCAT
CATTGAAGATATCAATGGGATTGAAACCATCAAGTCTTTGACCAGCGAAAAACAACGTTATCAGAAGATTGATAAGGAAT
TTGTGACTTATCTGAAAAAGTCTTTTGCTTACGGGCGTTCTGAGAGCCTACAAAAAGTCTTGAAAGCAGCAGCTCGTTTG
ATTTTAAACGTCTTGATTTTATGGCTAGGAGCTACACTTGTCATGGATCAAAAAATCAGCCTTGGTCAGCTCATTACTTA
TAACACACTTCTAGTCTACTTTACTAATCCTTTAGAAAATATTATCAATCTGCAAACGAAGTTACAGTCTGCACGAGTGG
CCAATGAGCGTCTCAATGAGGTCTATTTAGTCCAGTCTGAATTTGAAGAAGAGAAGCTTATTAAAGACTTGAGCCACTTT
CAGGCTGACATCGATTTTCGTGGAGTCAGCTATAAATATGGCTATGGGGCCAATGTATTATCAGAAATTGACTTGCATAT
TCCTGCTGGAAGTAAGACAAGCTTTGTTGGTGTATCCGGTTCAGGAAAAACAACCTTGGCCAAGATGATGGTGCATTTCT
ACGCTCCGAATCATGGGGATATTTGTTTGGGAGGAGTCAACCTCAATCAGCTGGATAAGCAGGCACTGCGCCAATATATC
AACTATCTTCCCCAGCAACCGTATGTTTTTAATGGAACTATTTTGGAAAATTTACTCTTAGGTGCGCGTGAAGGTACGAC
TCAAGAAGATATTCTGCGGGCGGTAGAATTGGCAGAAATTAGGTCGGATATTGAGCGGATGCCTCTCAATTATCAGACAG
AGCTGTCTGCAGATGGAGCAGGAATCTCGGGTGGTCAACGTCAGCGTATTGCTTTAGCAAGGGCTCTCTTGACAGATGCG
CCAGTGCTTATCTTAGATGAAGCAACGAGTAGTCTGGATATTCTAACAGAGAAGCGGATCATTGATAATCTGATGGCGCT
TGATAAGACGATTATTTTCATCGCGCATCGTTTGACTATTGCGGAACGTTCGGAGCAGGTGGTCGTTTTGGATCAAGGTA
GGATTGTCGAGAGTGGAAGTCATAAGGAGCTGATCGAAAGAGAAGGCTTTTACCACCATTTGGTCAATAGTTAG
ATGAAATTTAGGAAACGGCATTACAGAGCGCAAGTTGATACTAGGGATTGCGGTGTGGCAGCTCTGGCTATGGTTTTTGG
TTATTATGGATCGTATTTTTCCTTAGCTACACTGCGAGAAAAGGCAAAAACTACCAATGATGGCACAACTGCTTTGGGTT
TGGTAAAAGTTGCTGAGGGTCTAAATTTTGAGACAAGGGCTTTTAAAGCTGATATGGGAATCTTTGATCTGGAATATGTA
TCTTATCCTTTCATCGTTCATGTACTTAAGGAAGGGAAGCTCCTGCATTATTATGTTGTGACGGGACAAGATAAACACAC
GATTCATATTGCAGACCCAGACCCTCAAGTTAAGATGACAAAGATTTCGCGAGAGCGTTTTGAACAGGAGTGGACAGGAA
TTACCATTTTCCTAGCTCCTAGTCCAGCCTATAAGCCTAGTCAGGAAAAGAAGAATGGGCTTTTGGACTTCATTCCCTTA
TTGATCAAGCAAAAGGGGTTGATTACTAATATTGTGCTTGCAACTTTGCTGGTAACAGTGATTAATATTGTTGGATCTTA
CTACCTTCAGTCGATTATTGATACTTATGTGCCTGATCATATGAAAACGACGCTGGGTATGATTTCTATCGGCTTGATTA
TTGTCTATATTTTGCAGCAATTCTTGTCTTATGCCCAAGAATATTTGCTTTTGGTTTTAGGGCAGCGCCTATCGATTGAT
GTGATCTTATCCTATATTAAGCATGTTTTTCAGCTACCTATGTCATTTTTTGCGACAAGGCGGACAGGAGAAATCGTCTC
TCGTTTTACAGATGCCAATAGAATTATTGATGCTTTGGCCAGTACAATCTTGTCTATTTTCTTGGATGTATCGATTGTGT
CGATCATTGCGATTGTTCTTTTTTCACAAAATAGCAGTCTTTTCTTTTTGACCTTGTTAGGAATCCCAGTTTACGCTCTC
ATTATTTTTCTTTTTATGAAGCCTTTTGAAAAGATGAATCATGAGACGATGGAAGCAAATAGTTTGTTGTCGTCTTCCAT
CATTGAAGATATCAATGGGATTGAAACCATCAAGTCTTTGACCAGCGAAAAACAACGTTATCAGAAGATTGATAAGGAAT
TTGTGACTTATCTGAAAAAGTCTTTTGCTTACGGGCGTTCTGAGAGCCTACAAAAAGTCTTGAAAGCAGCAGCTCGTTTG
ATTTTAAACGTCTTGATTTTATGGCTAGGAGCTACACTTGTCATGGATCAAAAAATCAGCCTTGGTCAGCTCATTACTTA
TAACACACTTCTAGTCTACTTTACTAATCCTTTAGAAAATATTATCAATCTGCAAACGAAGTTACAGTCTGCACGAGTGG
CCAATGAGCGTCTCAATGAGGTCTATTTAGTCCAGTCTGAATTTGAAGAAGAGAAGCTTATTAAAGACTTGAGCCACTTT
CAGGCTGACATCGATTTTCGTGGAGTCAGCTATAAATATGGCTATGGGGCCAATGTATTATCAGAAATTGACTTGCATAT
TCCTGCTGGAAGTAAGACAAGCTTTGTTGGTGTATCCGGTTCAGGAAAAACAACCTTGGCCAAGATGATGGTGCATTTCT
ACGCTCCGAATCATGGGGATATTTGTTTGGGAGGAGTCAACCTCAATCAGCTGGATAAGCAGGCACTGCGCCAATATATC
AACTATCTTCCCCAGCAACCGTATGTTTTTAATGGAACTATTTTGGAAAATTTACTCTTAGGTGCGCGTGAAGGTACGAC
TCAAGAAGATATTCTGCGGGCGGTAGAATTGGCAGAAATTAGGTCGGATATTGAGCGGATGCCTCTCAATTATCAGACAG
AGCTGTCTGCAGATGGAGCAGGAATCTCGGGTGGTCAACGTCAGCGTATTGCTTTAGCAAGGGCTCTCTTGACAGATGCG
CCAGTGCTTATCTTAGATGAAGCAACGAGTAGTCTGGATATTCTAACAGAGAAGCGGATCATTGATAATCTGATGGCGCT
TGATAAGACGATTATTTTCATCGCGCATCGTTTGACTATTGCGGAACGTTCGGAGCAGGTGGTCGTTTTGGATCAAGGTA
GGATTGTCGAGAGTGGAAGTCATAAGGAGCTGATCGAAAGAGAAGGCTTTTACCACCATTTGGTCAATAGTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comA | Streptococcus gordonii str. Challis substr. CH1 |
98.187 |
100 |
0.982 |
| comA | Streptococcus pneumoniae Rx1 |
80.893 |
100 |
0.809 |
| comA | Streptococcus pneumoniae D39 |
80.893 |
100 |
0.809 |
| comA | Streptococcus pneumoniae R6 |
80.893 |
100 |
0.809 |
| comA | Streptococcus mitis NCTC 12261 |
80.753 |
100 |
0.808 |
| comA | Streptococcus mitis SK321 |
80.614 |
100 |
0.806 |
| comA | Streptococcus pneumoniae TIGR4 |
80.474 |
100 |
0.805 |
| comA/nlmT | Streptococcus mutans UA159 |
64.714 |
100 |
0.647 |