Detailed information
Bioinformatically predicted
Overview
| Name | comX/comX2 | Type | Regulator |
| Locus tag | SPN994039_RS00070 | Genome accession | NC_021005 |
| Coordinates | 14439..14918 (+) | Length | 159 a.a. |
| NCBI ID | WP_000588866.1 | Uniprot ID | A0A6C7J1A1 |
| Organism | Streptococcus pneumoniae SPN994039 | ||
| Function | activate transcription of late competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 12359..88077 | 14439..14918 | within | 0 |
Gene organization within MGE regions
Location: 12359..88077
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SPN994039_RS00065 (SPN994039_00130) | ftsH | 12359..14317 (+) | 1959 | WP_000744554.1 | ATP-dependent zinc metalloprotease FtsH | - |
| SPN994039_RS00070 (SPN994039_00140) | comX/comX2 | 14439..14918 (+) | 480 | WP_000588866.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| SPN994039_RS00105 | - | 20468..20677 (+) | 210 | Protein_14 | transposase | - |
| SPN994039_RS10970 (SPN994039_00150) | - | 20712..21509 (-) | 798 | Protein_15 | transposase | - |
| SPN994039_RS00125 (SPN994039_00160) | comW | 21775..22011 (+) | 237 | WP_000939546.1 | sigma(X)-activator ComW | Regulator |
| SPN994039_RS00130 (SPN994039_00170) | - | 22242..23528 (+) | 1287 | WP_000205044.1 | adenylosuccinate synthase | - |
| SPN994039_RS00135 (SPN994039_00180) | - | 23770..24918 (-) | 1149 | WP_000876732.1 | site-specific integrase | - |
| SPN994039_RS00140 (SPN994039_00190) | - | 25104..26027 (-) | 924 | WP_000122591.1 | exonuclease domain-containing protein | - |
| SPN994039_RS00145 (SPN994039_00200) | - | 26040..26423 (-) | 384 | WP_000136459.1 | ImmA/IrrE family metallo-endopeptidase | - |
| SPN994039_RS00150 (SPN994039_00210) | - | 26436..26801 (-) | 366 | WP_000492031.1 | helix-turn-helix transcriptional regulator | - |
| SPN994039_RS00155 (SPN994039_00230) | - | 27178..27399 (-) | 222 | WP_000041097.1 | hypothetical protein | - |
| SPN994039_RS12565 (SPN994039_00240) | - | 27518..27664 (+) | 147 | WP_000389576.1 | hypothetical protein | - |
| SPN994039_RS00160 (SPN994039_00250) | - | 27676..27879 (+) | 204 | WP_000032097.1 | helix-turn-helix transcriptional regulator | - |
| SPN994039_RS00165 | - | 27896..28093 (+) | 198 | WP_001057654.1 | hypothetical protein | - |
| SPN994039_RS12570 (SPN994039_00260) | - | 28104..28265 (+) | 162 | WP_001002946.1 | hypothetical protein | - |
| SPN994039_RS00170 (SPN994039_00270) | - | 28260..28685 (-) | 426 | WP_000386249.1 | hypothetical protein | - |
| SPN994039_RS00175 (SPN994039_00280) | - | 28739..29449 (+) | 711 | WP_001002359.1 | ORF6C domain-containing protein | - |
| SPN994039_RS00180 (SPN994039_00290) | - | 29463..29720 (+) | 258 | WP_000370959.1 | hypothetical protein | - |
| SPN994039_RS00185 (SPN994039_00300) | - | 29806..30126 (+) | 321 | WP_000462824.1 | hypothetical protein | - |
| SPN994039_RS00190 (SPN994039_00310) | - | 30142..30438 (+) | 297 | WP_000391805.1 | hypothetical protein | - |
| SPN994039_RS00195 (SPN994039_00320) | - | 30431..31237 (+) | 807 | WP_001289771.1 | phage replisome organizer N-terminal domain-containing protein | - |
| SPN994039_RS00200 (SPN994039_00340) | - | 31377..32147 (+) | 771 | WP_000228219.1 | ATP-binding protein | - |
| SPN994039_RS13285 | - | 32162..32356 (+) | 195 | WP_000470307.1 | hypothetical protein | - |
| SPN994039_RS00210 (SPN994039_00350) | - | 32356..32574 (+) | 219 | WP_000891962.1 | hypothetical protein | - |
| SPN994039_RS10980 | - | 32956..33054 (+) | 99 | Protein_36 | single-stranded DNA-binding protein | - |
| SPN994039_RS12575 (SPN994039_00370) | - | 33068..33235 (+) | 168 | WP_000233203.1 | hypothetical protein | - |
| SPN994039_RS00220 | - | 33222..33431 (+) | 210 | WP_000872740.1 | hypothetical protein | - |
| SPN994039_RS00225 (SPN994039_00380) | - | 33403..33720 (+) | 318 | WP_000969665.1 | hypothetical protein | - |
| SPN994039_RS12805 | - | 33722..33796 (+) | 75 | Protein_40 | DUF1642 domain-containing protein | - |
| SPN994039_RS00230 (SPN994039_00400) | - | 33973..34374 (+) | 402 | WP_000736390.1 | transcriptional activator | - |
| SPN994039_RS00235 (SPN994039_00410) | - | 34562..35104 (+) | 543 | WP_000397549.1 | site-specific integrase | - |
| SPN994039_RS00240 (SPN994039_00420) | - | 35481..35801 (+) | 321 | WP_000282427.1 | HNH endonuclease | - |
| SPN994039_RS00245 (SPN994039_00430) | - | 35938..36330 (+) | 393 | WP_001118283.1 | P27 family phage terminase small subunit | - |
| SPN994039_RS00250 (SPN994039_00440) | - | 36323..38053 (+) | 1731 | WP_000527299.1 | terminase large subunit | - |
| SPN994039_RS00255 | - | 38061..38279 (+) | 219 | WP_001002923.1 | hypothetical protein | - |
| SPN994039_RS00260 (SPN994039_00460) | - | 38297..39499 (+) | 1203 | WP_000510803.1 | phage portal protein | - |
| SPN994039_RS00265 (SPN994039_00470) | - | 39483..40058 (+) | 576 | WP_001172115.1 | HK97 family phage prohead protease | - |
| SPN994039_RS00270 (SPN994039_00480) | - | 40055..41221 (+) | 1167 | WP_001030357.1 | phage major capsid protein | - |
| SPN994039_RS00275 | - | 41233..41502 (+) | 270 | WP_000262606.1 | hypothetical protein | - |
| SPN994039_RS00280 (SPN994039_00500) | - | 41505..41786 (+) | 282 | WP_000370976.1 | hypothetical protein | - |
| SPN994039_RS00285 (SPN994039_00510) | - | 41773..42072 (+) | 300 | WP_000267055.1 | phage head closure protein | - |
| SPN994039_RS00290 (SPN994039_00520) | - | 42069..42416 (+) | 348 | WP_000063886.1 | HK97 gp10 family phage protein | - |
| SPN994039_RS00295 (SPN994039_00530) | - | 42413..42736 (+) | 324 | WP_000777003.1 | hypothetical protein | - |
| SPN994039_RS00300 (SPN994039_00540) | - | 42748..43326 (+) | 579 | WP_000191279.1 | major tail protein | - |
| SPN994039_RS00305 (SPN994039_00550) | - | 43338..43757 (+) | 420 | WP_001227146.1 | hypothetical protein | - |
| SPN994039_RS00310 (SPN994039_00560) | - | 44035..47130 (+) | 3096 | WP_000918318.1 | hypothetical protein | - |
| SPN994039_RS00315 (SPN994039_00570) | - | 47127..47849 (+) | 723 | WP_000589856.1 | hypothetical protein | - |
| SPN994039_RS12305 (SPN994039_00580) | - | 47850..54482 (+) | 6633 | WP_000966215.1 | phage tail spike protein | - |
| SPN994039_RS13290 (SPN994039_00590) | - | 54479..54595 (+) | 117 | WP_001063632.1 | hypothetical protein | - |
| SPN994039_RS00330 (SPN994039_00600) | - | 54576..54779 (+) | 204 | WP_001091113.1 | hypothetical protein | - |
| SPN994039_RS00335 (SPN994039_00610) | - | 54782..55132 (+) | 351 | WP_000852241.1 | hypothetical protein | - |
| SPN994039_RS00340 (SPN994039_00620) | - | 55141..55557 (+) | 417 | WP_001165344.1 | phage holin family protein | - |
| SPN994039_RS00345 (SPN994039_00630) | - | 55561..55893 (+) | 333 | WP_001186219.1 | phage holin | - |
| SPN994039_RS00350 (SPN994039_00640) | - | 55897..56853 (+) | 957 | WP_000350505.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| SPN994039_RS00360 | - | 57074..57262 (-) | 189 | WP_000109850.1 | hypothetical protein | - |
| SPN994039_RS00365 (SPN994039_00670) | tadA | 57830..58297 (+) | 468 | WP_000291870.1 | tRNA adenosine(34) deaminase TadA | - |
| SPN994039_RS00370 (SPN994039_00680) | - | 58483..58926 (+) | 444 | WP_000701992.1 | dUTP diphosphatase | - |
| SPN994039_RS00375 (SPN994039_00690) | - | 58928..59443 (+) | 516 | WP_001838385.1 | histidine phosphatase family protein | - |
| SPN994039_RS00380 (SPN994039_00700) | radA | 59457..60818 (+) | 1362 | WP_074017595.1 | DNA repair protein RadA | Machinery gene |
| SPN994039_RS00385 (SPN994039_00710) | - | 60891..61388 (+) | 498 | WP_001809263.1 | carbonic anhydrase | - |
| SPN994039_RS00395 (SPN994039_00720) | - | 61413..62243 (+) | 831 | Protein_72 | PrsW family glutamic-type intramembrane protease | - |
| SPN994039_RS00400 (SPN994039_00730) | - | 62388..63356 (+) | 969 | WP_000010163.1 | ribose-phosphate diphosphokinase | - |
| SPN994039_RS10995 (SPN994039_00740) | - | 63493..63771 (-) | 279 | Protein_74 | transposase family protein | - |
| SPN994039_RS12810 | - | 63815..64740 (-) | 926 | Protein_75 | Rpn family recombination-promoting nuclease/putative transposase | - |
| SPN994039_RS00425 (SPN994039_00770) | polA | 64996..67629 (+) | 2634 | WP_001809267.1 | DNA polymerase I | - |
| SPN994039_RS00430 (SPN994039_00780) | - | 67714..68151 (+) | 438 | WP_000076479.1 | CoA-binding protein | - |
| SPN994039_RS12815 | - | 68192..68620 (+) | 429 | WP_000693134.1 | hypothetical protein | - |
| SPN994039_RS00440 (SPN994039_00790) | - | 68649..69659 (-) | 1011 | WP_000009171.1 | YeiH family protein | - |
| SPN994039_RS00445 (SPN994039_00800) | - | 69808..70977 (+) | 1170 | WP_000366345.1 | pyridoxal phosphate-dependent aminotransferase | - |
| SPN994039_RS00450 (SPN994039_00810) | recO | 70974..71744 (+) | 771 | WP_000616162.1 | DNA repair protein RecO | - |
| SPN994039_RS00455 (SPN994039_00820) | plsX | 71741..72733 (+) | 993 | WP_000717457.1 | phosphate acyltransferase PlsX | - |
| SPN994039_RS00460 (SPN994039_00830) | - | 72739..72972 (+) | 234 | WP_000659556.1 | acyl carrier protein | - |
| SPN994039_RS11005 (SPN994039_00840) | - | 73018..73309 (+) | 292 | Protein_84 | IS5/IS1182 family transposase | - |
| SPN994039_RS00465 (SPN994039_00850) | blpU | 73512..73742 (+) | 231 | Protein_85 | bacteriocin-like peptide BlpU | - |
| SPN994039_RS13155 (SPN994039_00860) | - | 73745..73870 (+) | 126 | WP_000346297.1 | PncF family bacteriocin immunity protein | - |
| SPN994039_RS00480 (SPN994039_00870) | comA | 74457..76610 (+) | 2154 | WP_000668304.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| SPN994039_RS00485 (SPN994039_00880) | comB | 76623..77972 (+) | 1350 | WP_000801618.1 | competence pheromone export protein ComB | Regulator |
| SPN994039_RS00490 (SPN994039_00890) | purC | 78142..78849 (+) | 708 | WP_000043304.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| SPN994039_RS13295 | - | 78851..78994 (+) | 144 | WP_050167432.1 | hypothetical protein | - |
| SPN994039_RS00495 (SPN994039_00900) | - | 79051..82776 (+) | 3726 | WP_000361178.1 | phosphoribosylformylglycinamidine synthase | - |
| SPN994039_RS00500 (SPN994039_00910) | purF | 82869..84311 (+) | 1443 | WP_000220633.1 | amidophosphoribosyltransferase | - |
| SPN994039_RS00505 (SPN994039_00920) | purM | 84348..85370 (+) | 1023 | WP_000182558.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| SPN994039_RS00510 (SPN994039_00930) | purN | 85367..85912 (+) | 546 | WP_000717506.1 | phosphoribosylglycinamide formyltransferase | - |
| SPN994039_RS00515 (SPN994039_00940) | - | 85996..86505 (+) | 510 | WP_000894018.1 | VanZ family protein | - |
| SPN994039_RS00520 (SPN994039_00950) | purH | 86530..88077 (+) | 1548 | WP_000167082.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
Sequence
Protein
Download Length: 159 a.a. Molecular weight: 19845.46 Da Isoelectric Point: 7.3797
>NTDB_id=57915 SPN994039_RS00070 WP_000588866.1 14439..14918(+) (comX/comX2) [Streptococcus pneumoniae SPN994039]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLADDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGELSHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLADDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGELSHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH
Nucleotide
Download Length: 480 bp
>NTDB_id=57915 SPN994039_RS00070 WP_000588866.1 14439..14918(+) (comX/comX2) [Streptococcus pneumoniae SPN994039]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGCAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGCTCAGTCATCGTATAAGTGAGGGAGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGCAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGCTCAGTCATCGTATAAGTGAGGGAGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.