Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   GGS_RS05325 Genome accession   NC_018712
Coordinates   1066851..1067525 (-) Length   224 a.a.
NCBI ID   WP_003060678.1    Uniprot ID   A0AAE9R380
Organism   Streptococcus dysgalactiae subsp. equisimilis RE378     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1061851..1072525
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GGS_RS05300 (GGS_1009) - 1062037..1063314 (-) 1278 WP_015017041.1 pyrimidine-nucleoside phosphorylase -
  GGS_RS05305 (GGS_1010) - 1063301..1063900 (-) 600 WP_015057597.1 class I SAM-dependent methyltransferase -
  GGS_RS05310 (GGS_1011) coaA 1064169..1065088 (+) 920 Protein_1014 type I pantothenate kinase -
  GGS_RS05315 rpsT 1065142..1065390 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  GGS_RS05320 (GGS_1012) ciaH 1065548..1066858 (-) 1311 WP_012766987.1 HAMP domain-containing sensor histidine kinase Regulator
  GGS_RS05325 (GGS_1013) ciaR 1066851..1067525 (-) 675 WP_003060678.1 response regulator transcription factor Regulator
  GGS_RS05330 (GGS_1014) - 1067729..1070266 (-) 2538 WP_042357920.1 M1 family metallopeptidase -
  GGS_RS05335 (GGS_1015) phoU 1070467..1071120 (-) 654 WP_015017046.1 phosphate signaling complex protein PhoU -
  GGS_RS05340 (GGS_1016) pstB 1071198..1071956 (-) 759 WP_003057749.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25601.58 Da        Isoelectric Point: 4.4684

>NTDB_id=53965 GGS_RS05325 WP_003060678.1 1066851..1067525(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis RE378]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGQKEVQVDGRPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=53965 GGS_RS05325 WP_003060678.1 1066851..1067525(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis RE378]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGCTGATTATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACGGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAATGTCGTAG
TGGATTTAGGACAAAAAGAAGTTCAAGTGGATGGCCGGCCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTTTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae D39

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae R6

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae TIGR4

84.615

98.661

0.835
  ciaR Streptococcus mutans UA159

84.163

98.661

0.83
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.326

100

0.388
  vicR Streptococcus mutans UA159

35.443

100

0.375

Multiple sequence alignment