Detailed information NTG0053345

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: HMPREF1038_RS06055
• Genome accession: NC_018630
• Coordinates: 1139409..1140113 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae gamPNI0373
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1134409..1145113

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF1038_RS06025 (HMPREF1038_01224)	-	1134598..1135584 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
HMPREF1038_RS06030 (HMPREF1038_01225)	-	1135847..1136620 (-)	774	WP_025172523.1	potassium channel family protein	-
HMPREF1038_RS06035 (HMPREF1038_01226)	-	1136667..1136921 (-)	255	WP_001823540.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HMPREF1038_RS06040 (HMPREF1038_01227)	relB	1136923..1137165 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
HMPREF1038_RS06045 (HMPREF1038_01228)	vicX	1137256..1138065 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
HMPREF1038_RS06050 (HMPREF1038_01229)	micB	1138067..1139416 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
HMPREF1038_RS06055 (HMPREF1038_01230)	micA	1139409..1140113 (-)	705	WP_000722076.1	response regulator YycF	Regulator
HMPREF1038_RS06060 (HMPREF1038_01231)	mutY	1140168..1141343 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
HMPREF1038_RS13425 (HMPREF1038_01232)	-	1141440..1141565 (+)	126	WP_001818232.1	hypothetical protein	-
HMPREF1038_RS06065 (HMPREF1038_01233)	-	1141671..1143341 (-)	1671	WP_000845289.1	formate--tetrahydrofolate ligase	-
HMPREF1038_RS06070 (HMPREF1038_01234)	coaB	1143571..1144260 (+)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
HMPREF1038_RS06075 (HMPREF1038_01235)	coaC	1144272..1144823 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=53345 HMPREF1038_RS06055 WP_000722076.1 1139409..1140113(-) (micA) [Streptococcus pneumoniae gamPNI0373]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=53345 HMPREF1038_RS06055 WP_000722076.1 1139409..1140113(-) (micA) [Streptococcus pneumoniae gamPNI0373]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTACGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38