Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   HMPREF1038_RS02760 Genome accession   NC_018630
Coordinates   509005..511158 (-) Length   717 a.a.
NCBI ID   WP_000205159.1    Uniprot ID   G3EBW0
Organism   Streptococcus pneumoniae gamPNI0373     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 504005..516158
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF1038_RS02730 (HMPREF1038_00556) - 504337..504666 (-) 330 WP_000132583.1 hypothetical protein -
  HMPREF1038_RS02735 (HMPREF1038_00557) - 504943..505281 (+) 339 WP_000682136.1 LytTR family DNA-binding domain-containing protein -
  HMPREF1038_RS02740 (HMPREF1038_00558) comE/blpR 505286..506023 (+) 738 WP_001219137.1 LytTR family DNA-binding domain-containing protein Regulator
  HMPREF1038_RS02745 (HMPREF1038_00559) - 506037..507377 (+) 1341 WP_001099894.1 sensor histidine kinase -
  HMPREF1038_RS02750 (HMPREF1038_00560) blpC 507421..507576 (-) 156 WP_000358812.1 quorum-sensing system pheromone BlpC -
  HMPREF1038_RS02755 (HMPREF1038_00561) - 507633..508994 (-) 1362 WP_001069064.1 bacteriocin secretion accessory protein -
  HMPREF1038_RS02760 (HMPREF1038_00562) comA/nlmT 509005..511158 (-) 2154 WP_000205159.1 peptide cleavage/export ABC transporter BlpA Regulator
  HMPREF1038_RS02765 (HMPREF1038_00563) blpM 511440..511694 (+) 255 WP_001093255.1 two-peptide bacteriocin subunit BlpM -
  HMPREF1038_RS02770 (HMPREF1038_00564) blpN 511710..511913 (+) 204 WP_001099490.1 two-peptide bacteriocin subunit BlpN -
  HMPREF1038_RS02775 (HMPREF1038_00565) cipB 512157..512306 (+) 150 WP_001809846.1 bacteriocin-like peptide BlpO Regulator
  HMPREF1038_RS02780 (HMPREF1038_00567) - 512410..512529 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -
  HMPREF1038_RS02795 (HMPREF1038_00569) - 513010..513368 (+) 359 Protein_536 immunity protein -
  HMPREF1038_RS02805 (HMPREF1038_00570) - 513997..514380 (+) 384 WP_000877381.1 hypothetical protein -
  HMPREF1038_RS02810 (HMPREF1038_00571) - 514432..515121 (+) 690 WP_000760532.1 CPBP family intramembrane glutamic endopeptidase -
  HMPREF1038_RS02815 (HMPREF1038_00572) blpZ 515163..515396 (+) 234 WP_000276498.1 immunity protein BlpZ -
  HMPREF1038_RS02820 (HMPREF1038_00573) - 515547..516158 (+) 612 WP_000394044.1 CPBP family intramembrane glutamic endopeptidase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80835.85 Da        Isoelectric Point: 7.6610

>NTDB_id=53332 HMPREF1038_RS02760 WP_000205159.1 509005..511158(-) (comA/nlmT) [Streptococcus pneumoniae gamPNI0373]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINYQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLISLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=53332 HMPREF1038_RS02760 WP_000205159.1 509005..511158(-) (comA/nlmT) [Streptococcus pneumoniae gamPNI0373]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCTAGAGACTGCGGTGTTGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTGGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTTTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTCCTTTCTCTTCTTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTCG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGGCATATTTCCATCAATTATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAATTTAACCTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATCCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATCGCTCTCGCTCGTGCTCTTTTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATATCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGCTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(169-438)

ABC transporter (ABC_tran)

(500-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G3EBW0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.168

99.721

0.72
  comA Streptococcus mitis NCTC 12261

66.62

99.442

0.662
  comA Streptococcus pneumoniae Rx1

66.339

99.442

0.66
  comA Streptococcus pneumoniae D39

66.339

99.442

0.66
  comA Streptococcus pneumoniae R6

66.339

99.442

0.66
  comA Streptococcus mitis SK321

66.059

99.442

0.657
  comA Streptococcus pneumoniae TIGR4

66.059

99.442

0.657
  comA Streptococcus gordonii str. Challis substr. CH1

65.32

100

0.654

Multiple sequence alignment