Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6J12_RS09765 Genome accession   NZ_CP068060
Coordinates   2032252..2033442 (+) Length   396 a.a.
NCBI ID   WP_003032033.1    Uniprot ID   I0S836
Organism   Streptococcus anginosus strain FDAARGOS_1155     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2027252..2038442
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J12_RS09740 (I6J12_09740) comE/comE2 2029062..2029811 (-) 750 WP_003038257.1 competence system response regulator transcription factor ComE Regulator
  I6J12_RS09745 (I6J12_09745) comD/comD2 2029811..2031133 (-) 1323 WP_003038254.1 GHKL domain-containing protein Regulator
  I6J12_RS09750 (I6J12_09750) - 2031148..2031297 (-) 150 WP_003038250.1 bacteriocin -
  I6J12_RS09760 (I6J12_09760) rlmH 2031579..2032058 (-) 480 WP_004225060.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6J12_RS09765 (I6J12_09765) htrA 2032252..2033442 (+) 1191 WP_003032033.1 S1C family serine protease Regulator
  I6J12_RS09770 (I6J12_09770) spo0J 2033497..2034264 (+) 768 WP_003038259.1 ParB/RepB/Spo0J family partition protein Regulator
  I6J12_RS09775 (I6J12_09775) dnaA 2034493..2035836 (+) 1344 WP_004225063.1 chromosomal replication initiator protein DnaA -
  I6J12_RS09780 (I6J12_09780) dnaN 2035993..2037129 (+) 1137 WP_004225019.1 DNA polymerase III subunit beta -
  I6J12_RS09785 (I6J12_09785) - 2037129..2037326 (+) 198 WP_003038262.1 DUF951 domain-containing protein -
  I6J12_RS09790 (I6J12_09790) - 2037350..2037849 (-) 500 Protein_1948 DUF1307 domain-containing protein -

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41651.61 Da        Isoelectric Point: 9.4264

>NTDB_id=526819 I6J12_RS09765 WP_003032033.1 2032252..2033442(+) (htrA) [Streptococcus anginosus strain FDAARGOS_1155]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=526819 I6J12_RS09765 WP_003032033.1 2032252..2033442(+) (htrA) [Streptococcus anginosus strain FDAARGOS_1155]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0S836

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75.561

100

0.765
  htrA Streptococcus mitis NCTC 12261

72.544

100

0.727
  htrA Streptococcus pneumoniae Rx1

72.292

100

0.725
  htrA Streptococcus pneumoniae D39

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.292

100

0.725
  htrA Streptococcus pneumoniae TIGR4

72.292

100

0.725
  htrA Streptococcus mutans UA159

55.471

99.242

0.551