Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6J12_RS04740 Genome accession   NZ_CP068060
Coordinates   989020..989694 (-) Length   224 a.a.
NCBI ID   WP_003036714.1    Uniprot ID   -
Organism   Streptococcus anginosus strain FDAARGOS_1155     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 984020..994694
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J12_RS04725 (I6J12_04725) - 984055..985668 (-) 1614 WP_003036772.1 M20/M25/M40 family metallo-hydrolase -
  I6J12_RS04730 (I6J12_04730) - 985845..987293 (+) 1449 WP_003036764.1 alpha-amylase -
  I6J12_RS04735 (I6J12_04735) ciaH 987684..989030 (-) 1347 WP_003036710.1 sensor histidine kinase Regulator
  I6J12_RS04740 (I6J12_04740) ciaR 989020..989694 (-) 675 WP_003036714.1 response regulator transcription factor Regulator
  I6J12_RS04745 (I6J12_04745) - 989969..990424 (-) 456 WP_003036769.1 hypothetical protein -
  I6J12_RS04750 (I6J12_04750) - 990761..991504 (-) 744 WP_003036850.1 alpha/beta fold hydrolase -
  I6J12_RS04760 (I6J12_04760) rplS 991746..992093 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  I6J12_RS04765 (I6J12_04765) - 992243..993202 (-) 960 WP_003036699.1 ROK family glucokinase -
  I6J12_RS11290 - 993476..993772 (+) 297 WP_003036801.1 LysR family transcriptional regulator -
  I6J12_RS11295 - 993973..994251 (+) 279 WP_003036789.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25373.03 Da        Isoelectric Point: 4.2408

>NTDB_id=526800 I6J12_RS04740 WP_003036714.1 989020..989694(-) (ciaR) [Streptococcus anginosus strain FDAARGOS_1155]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=526800 I6J12_RS04740 WP_003036714.1 989020..989694(-) (ciaR) [Streptococcus anginosus strain FDAARGOS_1155]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATCTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGCGATGTCACTA
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.518

100

0.915
  ciaR Streptococcus pneumoniae D39

91.518

100

0.915
  ciaR Streptococcus pneumoniae R6

91.518

100

0.915
  ciaR Streptococcus pneumoniae TIGR4

91.518

100

0.915
  ciaR Streptococcus mutans UA159

89.686

99.554

0.893
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362