Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6J14_RS02325 Genome accession   NZ_CP068057
Coordinates   480222..480896 (+) Length   224 a.a.
NCBI ID   WP_003050941.1    Uniprot ID   A0A380JVA5
Organism   Streptococcus dysgalactiae strain FDAARGOS_1157     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 475222..485896
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J14_RS02310 (I6J14_02310) pstB 475791..476549 (+) 759 WP_003050947.1 phosphate ABC transporter ATP-binding protein PstB -
  I6J14_RS02315 (I6J14_02315) phoU 476627..477280 (+) 654 WP_003050946.1 phosphate signaling complex protein PhoU -
  I6J14_RS02320 (I6J14_02320) - 477480..480017 (+) 2538 WP_003050944.1 M1 family metallopeptidase -
  I6J14_RS02325 (I6J14_02325) ciaR 480222..480896 (+) 675 WP_003050941.1 response regulator transcription factor Regulator
  I6J14_RS02330 (I6J14_02330) ciaH 480889..482199 (+) 1311 WP_115252901.1 HAMP domain-containing sensor histidine kinase Regulator
  I6J14_RS02335 (I6J14_02335) rpsT 482357..482605 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  I6J14_RS02340 (I6J14_02340) coaA 482659..483579 (-) 921 WP_003050936.1 type I pantothenate kinase -
  I6J14_RS02345 (I6J14_02345) - 483848..484447 (+) 600 WP_037584951.1 class I SAM-dependent methyltransferase -
  I6J14_RS02350 (I6J14_02350) - 484434..485711 (+) 1278 WP_003050932.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25539.54 Da        Isoelectric Point: 4.4684

>NTDB_id=526710 I6J14_RS02325 WP_003050941.1 480222..480896(+) (ciaR) [Streptococcus dysgalactiae strain FDAARGOS_1157]
MLKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGKKEVQVDGQPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDLVDKLQTLRSVGYILKSHE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=526710 I6J14_RS02325 WP_003050941.1 480222..480896(+) (ciaR) [Streptococcus dysgalactiae strain FDAARGOS_1157]
ATGCTCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGAGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGTTTTCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCAGTGTTGATCATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACGGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAACGTCGTAG
TGGATTTAGGAAAAAAAGAAGTTCAAGTGGATGGCCAACCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTTTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATCTTGTGGACAAACTTCAGACATTAA
GAAGTGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380JVA5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

83.71

98.661

0.826
  ciaR Streptococcus pneumoniae D39

83.71

98.661

0.826
  ciaR Streptococcus pneumoniae R6

83.71

98.661

0.826
  ciaR Streptococcus pneumoniae TIGR4

83.71

98.661

0.826
  ciaR Streptococcus mutans UA159

83.258

98.661

0.821
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.778

100

0.379
  vicR Streptococcus mutans UA159

35.443

100

0.375