Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   JJN14_RS05730 Genome accession   NZ_CP067992
Coordinates   1179802..1180476 (-) Length   224 a.a.
NCBI ID   WP_000590639.1    Uniprot ID   A0A419RXM2
Organism   Streptococcus mitis strain S022-V7-A3     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1174802..1185476
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JJN14_RS05705 (JJN14_05705) - 1175064..1176275 (-) 1212 WP_004259464.1 phosphopentomutase -
  JJN14_RS05710 (JJN14_05710) rpiA 1176299..1176982 (-) 684 WP_201058098.1 ribose-5-phosphate isomerase RpiA -
  JJN14_RS05715 (JJN14_05715) - 1177088..1178017 (-) 930 WP_124787964.1 peptidase U32 family protein -
  JJN14_RS05720 (JJN14_05720) - 1178157..1178444 (+) 288 WP_201058099.1 DUF3270 domain-containing protein -
  JJN14_RS05725 (JJN14_05725) ciaH 1178478..1179812 (-) 1335 WP_201058100.1 two-component system sensor histidine kinase CiaH Regulator
  JJN14_RS05730 (JJN14_05730) ciaR 1179802..1180476 (-) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  JJN14_RS05735 (JJN14_05735) - 1180583..1183129 (-) 2547 WP_201058101.1 M1 family metallopeptidase -
  JJN14_RS05740 (JJN14_05740) - 1183252..1183692 (-) 441 WP_201058102.1 ASCH domain-containing protein -
  JJN14_RS05745 (JJN14_05745) - 1183723..1184421 (-) 699 WP_201058103.1 3-oxoacyl-ACP reductase -
  JJN14_RS05750 (JJN14_05750) - 1184414..1184650 (-) 237 WP_000141924.1 DUF2829 domain-containing protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=526160 JJN14_RS05730 WP_000590639.1 1179802..1180476(-) (ciaR) [Streptococcus mitis strain S022-V7-A3]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=526160 JJN14_RS05730 WP_000590639.1 1179802..1180476(-) (ciaR) [Streptococcus mitis strain S022-V7-A3]
ATGATAAAAATCTTATTAGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGATGATTTTGCGGATGT
CATGCAGGTATTTGATGGGGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTCGATTTGATGT
TACCTGAAAAAAACGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGGATTACGACTCCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCAGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGAATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAACACCTTGACATATGGAAATATTGTAG
TTAATTTGTCAACCAATACCGTTAAAGTCGAAGATACTCCTGTCGAATTGTTGGGGAAAGAGTTCGATTTATTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCGAAGACTCAGATTTTTGATCGTTTATGGGGATTTGATAGTGACACAACGAT
TTCAGTTGTCGAAGTTTACGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A419RXM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

88.839

100

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371