Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   JJN14_RS05725 Genome accession   NZ_CP067992
Coordinates   1178478..1179812 (-) Length   444 a.a.
NCBI ID   WP_201058100.1    Uniprot ID   -
Organism   Streptococcus mitis strain S022-V7-A3     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1173478..1184812
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JJN14_RS05695 (JJN14_05695) - 1173696..1174505 (-) 810 WP_201058096.1 purine-nucleoside phosphorylase -
  JJN14_RS05700 (JJN14_05700) - 1174502..1175062 (-) 561 WP_201058097.1 DUF1697 domain-containing protein -
  JJN14_RS05705 (JJN14_05705) - 1175064..1176275 (-) 1212 WP_004259464.1 phosphopentomutase -
  JJN14_RS05710 (JJN14_05710) rpiA 1176299..1176982 (-) 684 WP_201058098.1 ribose-5-phosphate isomerase RpiA -
  JJN14_RS05715 (JJN14_05715) - 1177088..1178017 (-) 930 WP_124787964.1 peptidase U32 family protein -
  JJN14_RS05720 (JJN14_05720) - 1178157..1178444 (+) 288 WP_201058099.1 DUF3270 domain-containing protein -
  JJN14_RS05725 (JJN14_05725) ciaH 1178478..1179812 (-) 1335 WP_201058100.1 two-component system sensor histidine kinase CiaH Regulator
  JJN14_RS05730 (JJN14_05730) ciaR 1179802..1180476 (-) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  JJN14_RS05735 (JJN14_05735) - 1180583..1183129 (-) 2547 WP_201058101.1 M1 family metallopeptidase -
  JJN14_RS05740 (JJN14_05740) - 1183252..1183692 (-) 441 WP_201058102.1 ASCH domain-containing protein -
  JJN14_RS05745 (JJN14_05745) - 1183723..1184421 (-) 699 WP_201058103.1 3-oxoacyl-ACP reductase -
  JJN14_RS05750 (JJN14_05750) - 1184414..1184650 (-) 237 WP_000141924.1 DUF2829 domain-containing protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50691.35 Da        Isoelectric Point: 8.2606

>NTDB_id=526159 JJN14_RS05725 WP_201058100.1 1178478..1179812(-) (ciaH) [Streptococcus mitis strain S022-V7-A3]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSNLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HQTIVTDQLLLKQLMTILFDNAIKYTEEDGEIDFMISATDRNLYLLVSDNGVGISAEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTVFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=526159 JJN14_RS05725 WP_201058100.1 1178478..1179812(-) (ciaH) [Streptococcus mitis strain S022-V7-A3]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTCACTCTGAT
TTTCTCTACCATGACTCTGATTATTTTACAAGTCATGCATTCGAATCTCTATACTTCGGTGGATGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAGGCAGTTATTCAGCTTGCTGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAGAATGCCGCT
ACAGATACTAGTAAGACTGAAGTAAAACCCAATGTCAGTTCCAATACGGAGGTTATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAACCGATTTTTGGGATTGGATAAGATTAAGTTAGAGAAAAAAGAACTAGGACATATCTATCAGATTC
AAGTTTTTAATAGCTATGGACAAGAAGAAATTTATCGCATGATTTTGATGGAAACGAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCGGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCCAGTCAAAAGCATGAGCAATTGATTGTAATTGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGCA
TGCAGAAGCAACAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTTGCAGTTTTGCAAAACCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCAACCATTATGGATGTGAGCGAAAGTATTGCCTCTAGTTTGGAAGAAGTCCGAAATAT
GCGGTTTTTGACGACGAACTTGTTGAATTTAGCTCGTAGAGATGATGGGATTAAGCCGGAACTTGCAGAAGTTCCAACCA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCTGAAAATGACCGTGTCTTTCGTTTTGAAAATCGTATC
CATCAAACGATTGTCACAGATCAGCTTCTTTTGAAACAACTGATGACCATTCTATTTGATAATGCCATCAAATATACTGA
GGAGGATGGTGAAATTGATTTTATGATTTCAGCGACTGATCGTAATCTTTATTTGCTAGTTTCCGACAATGGAGTCGGTA
TTTCAGCAGAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTGGACAAGGCTAGAACCCGTCAAAAAGGTGGTTTC
GGTTTAGGTTTATCCCTAGCCAAGCAAATTGTAGATGCCCTAAAAGGAACCATTACTGTTAAAGATAATAAACCGAAAGG
AACAGTCTTTGAAGTGAAGATTGCCATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

95.495

100

0.955
  ciaH Streptococcus pneumoniae D39

95.495

100

0.955
  ciaH Streptococcus pneumoniae R6

95.495

100

0.955
  ciaH Streptococcus pneumoniae TIGR4

95.495

100

0.955
  ciaH Streptococcus mutans UA159

55.172

97.973

0.541