Detailed information NTG0524341

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: JHX98_RS04810
• Genome accession: NZ_CP067010
• Coordinates: 921532..922368 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain iGAS376
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 916532..927368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JHX98_RS04780 (JHX98_04780)	-	917080..917454 (+)	375	WP_011054498.1	hypothetical protein	-
JHX98_RS04785 (JHX98_04785)	-	917504..918415 (-)	912	Protein_902	diacylglycerol kinase family protein	-
JHX98_RS04790 (JHX98_04790)	-	918532..919182 (-)	651	WP_002984629.1	hemolysin III family protein	-
JHX98_RS04795 (JHX98_04795)	-	919179..919619 (-)	441	WP_002984627.1	DUF1836 domain-containing protein	-
JHX98_RS04800 (JHX98_04800)	ylqF	919838..920686 (+)	849	WP_011888872.1	ribosome biogenesis GTPase YlqF	-
JHX98_RS04805 (JHX98_04805)	-	920676..921467 (+)	792	WP_011888871.1	ribonuclease HII	-
JHX98_RS04810 (JHX98_04810)	dprA	921532..922368 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
JHX98_RS04815 (JHX98_04815)	topA	922474..924603 (+)	2130	WP_011888870.1	type I DNA topoisomerase	-
JHX98_RS04820 (JHX98_04820)	trmFO	924738..926084 (+)	1347	WP_011888869.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=524341 JHX98_RS04810 WP_011017772.1 921532..922368(+) (dprA) [Streptococcus pyogenes strain iGAS376]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=524341 JHX98_RS04810 WP_011017772.1 921532..922368(+) (dprA) [Streptococcus pyogenes strain iGAS376]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTTCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367