Detailed information NTG0524290

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: JHX97_RS05080
• Genome accession: NZ_CP067009
• Coordinates: 966594..967430 (-)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain iGAS391
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 961594..972430

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JHX97_RS05070 (JHX97_05070)	trmFO	962878..964224 (-)	1347	WP_011888869.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-
JHX97_RS05075 (JHX97_05075)	topA	964359..966488 (-)	2130	WP_011888870.1	type I DNA topoisomerase	-
JHX97_RS05080 (JHX97_05080)	dprA	966594..967430 (-)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
JHX97_RS05085 (JHX97_05085)	-	967495..968286 (-)	792	WP_011888871.1	ribonuclease HII	-
JHX97_RS05090 (JHX97_05090)	ylqF	968276..969124 (-)	849	WP_011888872.1	ribosome biogenesis GTPase YlqF	-
JHX97_RS05095 (JHX97_05095)	-	969343..969783 (+)	441	WP_002984627.1	DUF1836 domain-containing protein	-
JHX97_RS05100 (JHX97_05100)	-	969780..970430 (+)	651	WP_002984629.1	hemolysin III family protein	-
JHX97_RS05105 (JHX97_05105)	-	970547..971458 (+)	912	Protein_971	diacylglycerol kinase family protein	-
JHX97_RS05110 (JHX97_05110)	-	971508..971882 (-)	375	WP_011054498.1	hypothetical protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=524290 JHX97_RS05080 WP_011017772.1 966594..967430(-) (dprA) [Streptococcus pyogenes strain iGAS391]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=524290 JHX97_RS05080 WP_011017772.1 966594..967430(-) (dprA) [Streptococcus pyogenes strain iGAS391]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTTCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367