Detailed information NTG0520662

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: JF649_RS00325
• Genome accession: NZ_CP066541
• Coordinates: 53238..54149 (+)
• Length: 303 a.a.
• NCBI ID: WP_020904818.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS270
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48238..59149

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JF649_RS00305 (JF649_00310)	purE	48522..49013 (+)	492	WP_023079042.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
JF649_RS00310 (JF649_00315)	purK	49000..50073 (+)	1074	WP_023610834.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
JF649_RS00315 (JF649_00320)	-	50100..51797 (+)	1698	WP_129321629.1	AIPR family protein	-
JF649_RS00320 (JF649_00325)	purB	51815..53107 (+)	1293	WP_129321630.1	adenylosuccinate lyase	-
JF649_RS00325 (JF649_00330)	comR	53238..54149 (+)	912	WP_020904818.1	XRE family transcriptional regulator	Regulator
JF649_RS00330	comS	54240..54338 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
JF649_RS00335 (JF649_00335)	ruvB	54369..55367 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
JF649_RS00340 (JF649_00340)	-	55505..55942 (+)	438	WP_002994668.1	low molecular weight phosphotyrosine protein phosphatase	-
JF649_RS00345 (JF649_00345)	-	55965..56366 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
JF649_RS00350 (JF649_00350)	-	56363..58138 (+)	1776	WP_129321631.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35887.54 Da
• Isoelectric Point: 4.9349

>NTDB_id=520662 JF649_RS00325 WP_020904818.1 53238..54149(+) (comR) [Streptococcus pyogenes strain MGAS270]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=520662 JF649_RS00325 WP_020904818.1 53238..54149(+) (comR) [Streptococcus pyogenes strain MGAS270]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366