Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SMUGS5_RS05060 Genome accession   NC_018089
Coordinates   1054761..1055435 (-) Length   224 a.a.
NCBI ID   WP_002262214.1    Uniprot ID   Q8DU28
Organism   Streptococcus mutans GS-5     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1049761..1060435
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUGS5_RS05035 (SMUGS5_04985) - 1050068..1051345 (-) 1278 WP_002281782.1 pyrimidine-nucleoside phosphorylase -
  SMUGS5_RS05040 (SMUGS5_04990) - 1051454..1052050 (-) 597 WP_002270201.1 class I SAM-dependent methyltransferase -
  SMUGS5_RS05045 (SMUGS5_04995) coaA 1052146..1053066 (+) 921 WP_002262217.1 type I pantothenate kinase -
  SMUGS5_RS05050 (SMUGS5_05000) rpsT 1053120..1053374 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUGS5_RS05055 (SMUGS5_05005) ciaH 1053464..1054771 (-) 1308 WP_002262215.1 three-component system sensor histidine kinase CiaH Regulator
  SMUGS5_RS05060 (SMUGS5_05010) ciaR 1054761..1055435 (-) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  SMUGS5_RS05065 (SMUGS5_05015) ciaX 1055486..1055749 (-) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUGS5_RS05070 (SMUGS5_05020) - 1056155..1058704 (-) 2550 WP_002268743.1 M1 family metallopeptidase -
  SMUGS5_RS05075 (SMUGS5_05025) phoU 1058745..1059398 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  SMUGS5_RS05080 (SMUGS5_05030) pstB 1059430..1060188 (-) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25475.23 Da        Isoelectric Point: 4.3425

>NTDB_id=52033 SMUGS5_RS05060 WP_002262214.1 1054761..1055435(-) (ciaR) [Streptococcus mutans GS-5]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=52033 SMUGS5_RS05060 WP_002262214.1 1054761..1055435(-) (ciaR) [Streptococcus mutans GS-5]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAATTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DU28

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

100

100

1
  ciaR Streptococcus pneumoniae Rx1

88.393

100

0.884
  ciaR Streptococcus pneumoniae D39

88.393

100

0.884
  ciaR Streptococcus pneumoniae R6

88.393

100

0.884
  ciaR Streptococcus pneumoniae TIGR4

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment