Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SMUGS5_RS05055 Genome accession   NC_018089
Coordinates   1053464..1054771 (-) Length   435 a.a.
NCBI ID   WP_002262215.1    Uniprot ID   -
Organism   Streptococcus mutans GS-5     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1048464..1059771
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUGS5_RS05025 (SMUGS5_04975) - 1049011..1049481 (-) 471 WP_012997758.1 cytidine deaminase -
  SMUGS5_RS05030 (SMUGS5_04980) deoC 1049387..1050049 (-) 663 WP_002262220.1 deoxyribose-phosphate aldolase -
  SMUGS5_RS05035 (SMUGS5_04985) - 1050068..1051345 (-) 1278 WP_002281782.1 pyrimidine-nucleoside phosphorylase -
  SMUGS5_RS05040 (SMUGS5_04990) - 1051454..1052050 (-) 597 WP_002270201.1 class I SAM-dependent methyltransferase -
  SMUGS5_RS05045 (SMUGS5_04995) coaA 1052146..1053066 (+) 921 WP_002262217.1 type I pantothenate kinase -
  SMUGS5_RS05050 (SMUGS5_05000) rpsT 1053120..1053374 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUGS5_RS05055 (SMUGS5_05005) ciaH 1053464..1054771 (-) 1308 WP_002262215.1 three-component system sensor histidine kinase CiaH Regulator
  SMUGS5_RS05060 (SMUGS5_05010) ciaR 1054761..1055435 (-) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  SMUGS5_RS05065 (SMUGS5_05015) ciaX 1055486..1055749 (-) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUGS5_RS05070 (SMUGS5_05020) - 1056155..1058704 (-) 2550 WP_002268743.1 M1 family metallopeptidase -
  SMUGS5_RS05075 (SMUGS5_05025) phoU 1058745..1059398 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49868.35 Da        Isoelectric Point: 9.7262

>NTDB_id=52032 SMUGS5_RS05055 WP_002262215.1 1053464..1054771(-) (ciaH) [Streptococcus mutans GS-5]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHIINKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=52032 SMUGS5_RS05055 WP_002262215.1 1053464..1054771(-) (ciaH) [Streptococcus mutans GS-5]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCGGAAATAACAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTATCAATAAGGTCAACCGTCAA
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAGAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

100

100

1
  ciaH Streptococcus pneumoniae Rx1

55.632

100

0.556
  ciaH Streptococcus pneumoniae D39

55.632

100

0.556
  ciaH Streptococcus pneumoniae R6

55.632

100

0.556
  ciaH Streptococcus pneumoniae TIGR4

55.632

100

0.556

Multiple sequence alignment