Detailed information NTG0052005

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SMUGS5_RS00350
• Genome accession: NC_018089
• Coordinates: 58946..59860 (+)
• Length: 304 a.a.
• NCBI ID: WP_002307469.1
• Uniprot ID: -
• Organism: Streptococcus mutans GS-5
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 53946..64860

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUGS5_RS00325 (SMUGS5_00235)	-	54391..54810 (+)	420	WP_014834780.1	SRPBCC family protein	-
SMUGS5_RS00330 (SMUGS5_00240)	-	54914..55510 (+)	597	WP_014834781.1	hypothetical protein	-
SMUGS5_RS00335 (SMUGS5_00245)	-	55532..56263 (+)	732	WP_014834782.1	hypothetical protein	-
SMUGS5_RS00340 (SMUGS5_00250)	purB	56556..57854 (+)	1299	WP_014834783.1	adenylosuccinate lyase	-
SMUGS5_RS00345	-	57874..58563 (+)	690	WP_042899543.1	DNA alkylation repair protein	-
SMUGS5_RS00350 (SMUGS5_00260)	comR	58946..59860 (+)	915	WP_002307469.1	helix-turn-helix domain-containing protein	Regulator
SMUGS5_RS00355 (SMUGS5_00265)	-	60322..62166 (-)	1845	WP_002267914.1	carbohydrate-binding domain-containing protein	-
SMUGS5_RS00360 (SMUGS5_00270)	ruvB	62502..63497 (+)	996	WP_002269367.1	Holliday junction branch migration DNA helicase RuvB	-
SMUGS5_RS00365 (SMUGS5_00275)	-	63535..63960 (+)	426	WP_002263403.1	low molecular weight protein-tyrosine-phosphatase	-
SMUGS5_RS00370 (SMUGS5_00280)	-	64025..64408 (+)	384	WP_011074470.1	membrane protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35203.27 Da
• Isoelectric Point: 4.9127

>NTDB_id=52005 SMUGS5_RS00350 WP_002307469.1 58946..59860(+) (comR) [Streptococcus mutans GS-5]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMA
RTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=52005 SMUGS5_RS00350 WP_002307469.1 58946..59860(+) (comR) [Streptococcus mutans GS-5]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAGGCTGTCTGCCTTGATGA
ATCGCAGTTGTCAACACGGCAGCTGACTAGAATTGAATCAGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGACGTTTAGGAGTAACGCTTGGCTATTTAACGGACGGAGAGAATGTCGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGACCAACAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGTTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACTAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTTAGCAATAAAATCATGGCT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GGAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAAAACGGGACATAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (9-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	99.671	100	0.997
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.778	94.737	0.5
comR	Streptococcus pyogenes MGAS8232	46.689	99.342	0.464
comR	Streptococcus pyogenes MGAS315	47.157	98.355	0.464
comR	Streptococcus suis P1/7	43.813	98.355	0.431
comR	Streptococcus suis 05ZYH33	43.813	98.355	0.431
comR	Streptococcus suis D9	37	98.684	0.365