Detailed information NTG0519150

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: IGS65_RS07960
• Genome accession: NZ_CP066294
• Coordinates: 1600700..1601614 (+)
• Length: 304 a.a.
• NCBI ID: WP_002275820.1
• Uniprot ID: A0AAX1K1I3
• Organism: Streptococcus mutans strain 27-3
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1595700..1606614

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IGS65_RS07935 (IGS65_007935)	-	1596309..1596920 (+)	612	WP_002273256.1	CPBP family intramembrane glutamic endopeptidase	-
IGS65_RS07940 (IGS65_007940)	-	1596964..1597380 (+)	417	WP_002286077.1	SRPBCC family protein	-
IGS65_RS07945 (IGS65_007945)	-	1597408..1598283 (+)	876	WP_002269364.1	hypothetical protein	-
IGS65_RS07950 (IGS65_007950)	purB	1598300..1599598 (+)	1299	WP_192072008.1	adenylosuccinate lyase	-
IGS65_RS07955 (IGS65_007955)	-	1599618..1600304 (+)	687	WP_002303974.1	DNA alkylation repair protein	-
IGS65_RS07960 (IGS65_007960)	comR	1600700..1601614 (+)	915	WP_002275820.1	helix-turn-helix domain-containing protein	Regulator
IGS65_RS07965 (IGS65_007965)	-	1602146..1603987 (-)	1842	WP_192072009.1	carbohydrate-binding domain-containing protein	-
IGS65_RS07970 (IGS65_007970)	ruvB	1604323..1605318 (+)	996	WP_002284808.1	Holliday junction branch migration DNA helicase RuvB	-
IGS65_RS07975 (IGS65_007975)	-	1605356..1605781 (+)	426	WP_002278431.1	low molecular weight protein-tyrosine-phosphatase	-
IGS65_RS07980 (IGS65_007980)	-	1605846..1606229 (+)	384	WP_011074470.1	membrane protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35228.36 Da
• Isoelectric Point: 5.0064

>NTDB_id=519150 IGS65_RS07960 WP_002275820.1 1600700..1601614(+) (comR) [Streptococcus mutans strain 27-3]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMA
RTYDFQKKPIVNLLTWKHHLFVEKDYAKAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=519150 IGS65_RS07960 WP_002275820.1 1600700..1601614(+) (comR) [Streptococcus mutans strain 27-3]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAGGCTGTCTGCCTTGATGA
ATCGCAGTTGTCAACACGGCAGCTGACTAGAATTGAATCGGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGACGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTTGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGACCAGCAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGTTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATAAAATCATGGCT
AGAACTTATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GAAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (9-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	99.013	100	0.99
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.431	94.737	0.497
comR	Streptococcus pyogenes MGAS8232	47.02	99.342	0.467
comR	Streptococcus pyogenes MGAS315	47.157	98.355	0.464
comR	Streptococcus suis 05ZYH33	43.478	98.355	0.428
comR	Streptococcus suis P1/7	43.478	98.355	0.428
comR	Streptococcus suis D9	37	98.684	0.365