Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR/comR1   Type   Regulator
Locus tag   IGS65_RS05960 Genome accession   NZ_CP066294
Coordinates   1219505..1220407 (+) Length   300 a.a.
NCBI ID   WP_192072072.1    Uniprot ID   A0AAX1K0T2
Organism   Streptococcus mutans strain 27-3     
Function   repress natural transformation (predicted from homology)   
Competence regulation

Genomic Context

Location: 1214505..1225407
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IGS65_RS05935 (IGS65_005935) rimI 1215334..1215768 (-) 435 WP_002264347.1 ribosomal protein S18-alanine N-acetyltransferase -
  IGS65_RS05940 (IGS65_005940) tsaB 1215768..1216454 (-) 687 WP_002304697.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB -
  IGS65_RS05945 (IGS65_005945) - 1216465..1216923 (-) 459 WP_002269503.1 winged helix DNA-binding protein -
  IGS65_RS05950 (IGS65_005950) - 1217097..1218143 (+) 1047 WP_192072074.1 SDR family oxidoreductase -
  IGS65_RS05955 (IGS65_005955) - 1218164..1219132 (+) 969 WP_192072073.1 aldo/keto reductase -
  IGS65_RS05960 (IGS65_005960) comR/comR1 1219505..1220407 (+) 903 WP_192072072.1 XRE family transcriptional regulator Regulator
  IGS65_RS05965 (IGS65_005965) - 1220913..1221050 (-) 138 WP_002262470.1 hypothetical protein -
  IGS65_RS05970 (IGS65_005970) - 1221028..1221267 (-) 240 WP_002262471.1 hypothetical protein -
  IGS65_RS05975 (IGS65_005975) - 1221285..1221428 (-) 144 WP_002268033.1 hypothetical protein -
  IGS65_RS05980 (IGS65_005980) - 1221633..1222871 (-) 1239 WP_192072071.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
  IGS65_RS05985 (IGS65_005985) - 1222887..1223795 (-) 909 WP_002262474.1 hypothetical protein -
  IGS65_RS05990 (IGS65_005990) - 1223806..1224516 (-) 711 WP_002262475.1 SDR family oxidoreductase -
  IGS65_RS05995 (IGS65_005995) - 1224503..1225246 (-) 744 WP_024783849.1 methyltransferase domain-containing protein -

Sequence

Protein


Download         Length: 300 a.a.        Molecular weight: 35103.22 Da        Isoelectric Point: 4.4185

>NTDB_id=519134 IGS65_RS05960 WP_192072072.1 1219505..1220407(+) (comR/comR1) [Streptococcus mutans strain 27-3]
MTIKEDLGRRIKAERNRKQLTQSLLCGDETKLTIRQLQRIEGGQSLPTLEKLEFIADRLGTKIADLLEGSDIQLPDDYWE
LKGQIVKFPTYADKERLQQKQELIEEIYDKYFDILPEDELLFLDLSENILDSFHEKDIPNIEEIYDDAFEQVLKKETFAF
NDYLYMSYFLQKCGKTEDYDRTTFKLLEKKLLNQELTADELYNIEFLIAVMEASGVYAFHDDYQNLLPLLEKAQRIIDKA
QLHTYKPPLLELEAKYYVKVVKDKKKAKELYQQALVMGEVLGDPVIIADVKMEMANDGID

Nucleotide


Download         Length: 903 bp        

>NTDB_id=519134 IGS65_RS05960 WP_192072072.1 1219505..1220407(+) (comR/comR1) [Streptococcus mutans strain 27-3]
ATGACAATAAAAGAAGATTTAGGACGGCGGATTAAAGCAGAAAGGAATCGCAAGCAACTCACACAAAGCCTTTTGTGCGG
AGATGAAACAAAACTGACCATTCGACAGCTTCAGCGGATTGAGGGCGGGCAGTCTTTGCCGACCCTAGAAAAATTAGAAT
TCATTGCTGATCGCTTAGGAACTAAAATAGCCGACCTGCTGGAAGGCAGCGATATCCAGCTGCCAGATGATTACTGGGAG
CTAAAGGGGCAGATTGTTAAATTTCCCACCTATGCTGATAAGGAAAGACTTCAGCAAAAACAGGAGCTGATCGAAGAAAT
CTATGACAAATACTTTGATATCCTGCCTGAGGATGAACTGCTCTTTTTAGATTTGTCAGAGAATATCCTAGACAGTTTTC
ATGAAAAAGACATTCCTAACATTGAGGAGATTTACGACGATGCCTTTGAGCAAGTCCTCAAAAAGGAGACCTTTGCCTTT
AATGACTATCTTTACATGAGCTATTTTTTACAGAAGTGCGGAAAAACAGAGGACTATGATCGGACAACTTTCAAGCTGCT
TGAGAAAAAGTTGCTCAATCAAGAGCTAACAGCAGACGAACTTTATAATATTGAATTTTTGATTGCTGTTATGGAGGCAT
CAGGTGTTTATGCCTTTCATGATGATTATCAGAATCTGCTTCCTTTGTTAGAGAAGGCTCAGCGAATTATTGATAAGGCT
CAGCTTCACACCTATAAACCGCCACTTTTAGAACTTGAAGCCAAGTACTATGTCAAGGTTGTCAAGGATAAGAAAAAAGC
TAAGGAACTCTATCAGCAAGCCTTGGTGATGGGCGAAGTTCTAGGTGATCCTGTTATAATTGCAGATGTTAAGATGGAGA
TGGCAAATGATGGGATAGACTAG

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(75-294)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

76.333

100

0.763
  comR/comR2 Streptococcus sobrinus strain NIDR 6715-7

70

100

0.7
  comR Streptococcus salivarius strain HSISS4

42.809

99.667

0.427
  comR Streptococcus thermophilus LMD-9

42.475

99.667

0.423
  comR Streptococcus thermophilus LMG 18311

42.475

99.667

0.423
  comR Streptococcus salivarius SK126

41.806

99.667

0.417