NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	JDY60_RS04470	Genome accession	NZ_CP066172
Coordinates	925611..926285 (-)	Length	224 a.a.
NCBI ID	WP_000590635.1	Uniprot ID	A0A139R176
Organism	Streptococcus oralis strain SF100
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 920611..931285

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JDY60_RS04445 (JDY60_04445)	-	920745..921674 (-)	930	WP_125456908.1	peptidase U32 family protein	-
JDY60_RS04450 (JDY60_04450)	-	921800..922480 (-)	681	WP_000209231.1	ABC transporter ATP-binding protein	-
JDY60_RS04455 (JDY60_04455)	-	922494..923549 (-)	1056	WP_049479725.1	ABC transporter permease	-
JDY60_RS04460 (JDY60_04460)	-	923935..924219 (+)	285	WP_200371547.1	DUF3270 domain-containing protein	-
JDY60_RS04465 (JDY60_04465)	ciaH	924284..925621 (-)	1338	WP_200371549.1	cell wall metabolism sensor histidine kinase WalK	Regulator
JDY60_RS04470 (JDY60_04470)	ciaR	925611..926285 (-)	675	WP_000590635.1	two-component system response regulator CiaR	Regulator
JDY60_RS04475 (JDY60_04475)	-	926394..928940 (-)	2547	WP_200371550.1	M1 family metallopeptidase	-
JDY60_RS04480 (JDY60_04480)	-	929061..929501 (-)	441	WP_000188825.1	ASCH domain-containing protein	-
JDY60_RS04485 (JDY60_04485)	-	929498..930346 (-)	849	WP_200371552.1	putative PEP-binding protein	-
JDY60_RS04490 (JDY60_04490)	-	930388..931116 (-)	729	WP_000418697.1	GNAT family N-acetyltransferase	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25465.26 Da Isoelectric Point: 4.2660

                                >NTDB_id=518047 JDY60_RS04470 WP_000590635.1 925611..926285(-) (ciaR) [Streptococcus oralis strain SF100]

MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVVVNLSTNEVKVEDTPVELLGKEFELLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

Download Length: 675 bp

                                >NTDB_id=518047 JDY60_RS04470 WP_000590635.1 925611..926285(-) (ciaR) [Streptococcus oralis strain SF100]

ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGTCTGTCAAACTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT

CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCAGAAAGTGGCGTTTATGACTTGATTTTGCTTGACCTGATGT

TGCCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAGTTGCGCGAAAAAGGAATTACCACACCAGTCCTTATCATGACGGCC

AAAGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTCTATCTAGAAGA

ACTCAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAACACCTTGACCTATGGGGATGTTGTCG

TAAACCTTTCAACGAATGAAGTAAAAGTGGAAGATACTCCTGTGGAACTGCTCGGGAAAGAGTTTGAGTTATTGGTTTAT

TTCCTTCAAAATCAAAATGTTATTCTTCCTAAGACGCAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT

TTCCGTTGTAGAAGTCTATGTTTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACTTTGC

GTAGTGTCGGGTATATATTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A139R176

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae TIGR4	97.321	100	0.973
ciaR	Streptococcus pneumoniae D39	97.321	100	0.973
ciaR	Streptococcus pneumoniae R6	97.321	100	0.973
ciaR	Streptococcus pneumoniae Rx1	97.321	100	0.973
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366

Detailed information NTG0518047