Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   I6H78_RS07160 Genome accession   NZ_CP066059
Coordinates   1485185..1487338 (-) Length   717 a.a.
NCBI ID   WP_198459241.1    Uniprot ID   A0A7T4IRY3
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1480185..1492338
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS07130 (I6H78_07130) - 1480274..1480603 (-) 330 WP_125418557.1 helicase BlpT -
  I6H78_RS07135 (I6H78_07135) - 1480884..1481222 (+) 339 WP_125418559.1 LytTR family DNA-binding domain-containing protein -
  I6H78_RS07140 (I6H78_07140) comE/blpR 1481227..1481964 (+) 738 WP_198459240.1 response regulator transcription factor Regulator
  I6H78_RS07145 (I6H78_07145) - 1481978..1483318 (+) 1341 WP_125418563.1 sensor histidine kinase -
  I6H78_RS07150 (I6H78_07150) blpC 1483598..1483756 (-) 159 WP_125418565.1 quorum-sensing system pheromone BlpC -
  I6H78_RS07155 (I6H78_07155) - 1483813..1485174 (-) 1362 WP_125418567.1 bacteriocin secretion accessory protein -
  I6H78_RS07160 (I6H78_07160) comA/nlmT 1485185..1487338 (-) 2154 WP_198459241.1 peptide cleavage/export ABC transporter BlpA Regulator
  I6H78_RS07165 (I6H78_07165) - 1487619..1487822 (+) 204 WP_125418571.1 Blp family class II bacteriocin -
  I6H78_RS07170 (I6H78_07170) - 1488136..1488339 (+) 204 WP_038804511.1 hypothetical protein -
  I6H78_RS07175 (I6H78_07175) - 1488909..1489070 (+) 162 WP_198459242.1 hypothetical protein -
  I6H78_RS07180 (I6H78_07180) - 1489067..1489471 (+) 405 WP_198459243.1 immunity protein -
  I6H78_RS07185 (I6H78_07185) - 1489632..1490597 (+) 966 WP_198459244.1 thioredoxin domain-containing protein -
  I6H78_RS07190 (I6H78_07190) - 1490844..1491077 (+) 234 WP_001093253.1 bacteriocin class II family protein -
  I6H78_RS07195 (I6H78_07195) - 1491109..1491798 (+) 690 WP_198459245.1 CPBP family intramembrane glutamic endopeptidase -
  I6H78_RS07200 (I6H78_07200) blpM 1492021..1492275 (+) 255 WP_198459246.1 two-peptide bacteriocin subunit BlpM -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80805.80 Da        Isoelectric Point: 7.3566

>NTDB_id=516988 I6H78_RS07160 WP_198459241.1 1485185..1487338(-) (comA/nlmT) [Streptococcus oralis strain FDAARGOS_1021]
MTSYKRTFVPQIDARDCGVATLASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMRSTLGIISIGLIITYILQQAMSFSRDYLLTVLSQRLSID
VILAYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLLLDVSILILVGSVLLAQNPNLFLLSLISIPIYIF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLTKYSILQTNLKQGTKL
VLNIFILWFGAQLVMSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSNFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKEGDKVSLVGVSGSGKTTLAKMIVNFFDPYKGQITINHQDIKNIDKKILRRHI
NYLPQQAYIFNGSILENLTLGGNSMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSALDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELIQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=516988 I6H78_RS07160 WP_198459241.1 1485185..1487338(-) (comA/nlmT) [Streptococcus oralis strain FDAARGOS_1021]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCTAGAGACTGTGGTGTCGCTACCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACTACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACGCTCTTTGATATGAGCGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGGAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGATCCTTCTGTAAAAATCACCAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTGAGCTTCCTCCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTGGATGAGTACATCCCAAATCAGATGAGATCAACTTTAGGAATCATCTCAATTGGTCTAATTA
TCACCTATATTCTCCAACAAGCCATGAGCTTCTCCAGAGATTATCTCCTAACTGTTCTGAGTCAGAGATTAAGCATTGAT
GTAATTTTGGCCTATATTCGCCATATCTTTGAACTTCCTATGTCTTTCTTTGCGACACGTCGTACAGGGGAAATCATTTC
ACGATTCACAGATGCCAACTCTATTATAGATGCCTTAGCTTCTACCATTCTCTCTCTTCTTCTTGATGTTTCCATTCTGA
TCCTTGTAGGGAGTGTCTTACTGGCACAAAATCCTAACCTCTTTCTTCTTTCTCTTATTTCTATCCCTATTTACATATTC
ATCATCTTTTCTTTTATGAAACCTTTTGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGTTCTGCTAT
TATCGAAGATATCAACGGGATCGAAACCATCAAGTCACTCACAAGTGAAGAAAATCGCTACCAAAATATTGACAGTGAAT
TTGTCGATTATTTGGAAAAATCCTTTAAACTTACTAAATATTCTATTTTACAAACTAATTTAAAACAAGGAACAAAGTTA
GTTCTTAATATCTTTATCCTATGGTTTGGTGCTCAATTAGTCATGTCGAGTAAGATTTCTATCGGTCAGCTGATTACCTT
TAATACACTTCTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTACAAACTAAACTCCAATCTGCGAAGGTTG
CTAATAACCGCTTGAACGAGGTCTACTTAGTCGAATCTGAATTTCAAGTTCAAGAAAATCCTGTTCATTCAAATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGGCGAGATACCTTAACAGATATCAATCTAACGAT
TAAAGAAGGTGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTCTAGCCAAAATGATTGTCAACTTCT
TTGACCCTTACAAAGGACAGATTACCATCAATCATCAGGATATTAAAAATATTGATAAAAAAATCTTGCGACGTCATATT
AATTACCTGCCCCAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACCTTGGGCGGTAATAGTATGATTAG
CCAAGAAGATATTCTAAAAGCTTGCGAATTAGCTGAAATCCGTCAAGATATTGAAAGAATGCCTATGGGCTATCAAACTC
AACTTTCTGATGGAGCAGGTCTGTCAGGAGGACAGAAGCAACGAATCGCCCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGATGAAGCTACTAGTGCTCTCGATGTTTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTAAGTATAGCCGAACGGACTAACCGTGTCATTGTTCTTGACCAAGGGA
AAATCATTGAAGTTGGTAGTCATCAAGAGTTAATACAGGCGCAAGGCTTCTACCATCATCTATTCAACAAATAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T4IRY3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.469

99.721

0.713
  comA Streptococcus mitis NCTC 12261

66.059

99.442

0.657
  comA Streptococcus mitis SK321

65.498

99.442

0.651
  comA Streptococcus pneumoniae Rx1

65.498

99.442

0.651
  comA Streptococcus pneumoniae D39

65.498

99.442

0.651
  comA Streptococcus pneumoniae R6

65.498

99.442

0.651
  comA Streptococcus pneumoniae TIGR4

65.217

99.442

0.649
  comA Streptococcus gordonii str. Challis substr. CH1

64.575

100

0.646