NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	I6H78_RS07140	Genome accession	NZ_CP066059
Coordinates	1481227..1481964 (+)	Length	245 a.a.
NCBI ID	WP_198459240.1	Uniprot ID	A0A7T4M116
Organism	Streptococcus oralis strain FDAARGOS_1021
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1476227..1486964

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H78_RS07110 (I6H78_07110)	-	1477573..1477860 (-)	288	WP_198459236.1	hypothetical protein	-
I6H78_RS07115 (I6H78_07115)	-	1477870..1478280 (-)	411	WP_198459237.1	HIT family protein	-
I6H78_RS07120 (I6H78_07120)	pptA	1478348..1479079 (+)	732	WP_198459238.1	ABC transporter ATP-binding protein	Regulator
I6H78_RS07125 (I6H78_07125)	-	1479076..1480125 (+)	1050	WP_198459239.1	ABC transporter permease	-
I6H78_RS07130 (I6H78_07130)	-	1480274..1480603 (-)	330	WP_125418557.1	helicase BlpT	-
I6H78_RS07135 (I6H78_07135)	-	1480884..1481222 (+)	339	WP_125418559.1	LytTR family DNA-binding domain-containing protein	-
I6H78_RS07140 (I6H78_07140)	comE/blpR	1481227..1481964 (+)	738	WP_198459240.1	response regulator transcription factor	Regulator
I6H78_RS07145 (I6H78_07145)	-	1481978..1483318 (+)	1341	WP_125418563.1	sensor histidine kinase	-
I6H78_RS07150 (I6H78_07150)	blpC	1483598..1483756 (-)	159	WP_125418565.1	quorum-sensing system pheromone BlpC	-
I6H78_RS07155 (I6H78_07155)	-	1483813..1485174 (-)	1362	WP_125418567.1	bacteriocin secretion accessory protein	-

Sequence

Protein

Download Length: 245 a.a. Molecular weight: 28729.96 Da Isoelectric Point: 5.7365

                                >NTDB_id=516987 I6H78_RS07140 WP_198459240.1 1481227..1481964(+) (comE/blpR) [Streptococcus oralis strain FDAARGOS_1021]

MRIFVLEDDFSQQVRIETTIEKLLKKQSIIPSSFEVFGKPDQLLAEVDEKGVHQLFFLDIEIRNEEMKGLEVARKIRDRD

PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSTEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY

LETSPRAHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVQLDKKEKLLFFPNGGSCLIARYKVREVSEA

INNLH

Nucleotide

Download Length: 738 bp

                                >NTDB_id=516987 I6H78_RS07140 WP_198459240.1 1481227..1481964(+) (comE/blpR) [Streptococcus oralis strain FDAARGOS_1021]

ATGAGAATATTTGTTTTAGAAGATGACTTTTCCCAACAAGTTAGAATTGAAACGACGATTGAAAAACTTTTGAAAAAACA

GAGTATCATTCCTAGTTCTTTTGAAGTCTTTGGGAAACCAGACCAACTGCTGGCAGAGGTGGATGAGAAGGGGGTGCATC

AGCTTTTCTTTTTGGATATTGAGATTCGAAACGAAGAGATGAAGGGGCTAGAAGTGGCTAGAAAGATTCGGGATCGGGAT

CCTTATGCTCTAATCGTCTTTGTGACAACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA

CTACATTGATAAGGCCTTGTCGACAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA

GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCCTTTAAAGAGGTTTACTAT

CTCGAAACGTCGCCTAGAGCCCATCGTGTTATTCTCTATACCAAGACGGATAGGTTGGAATTTACAGCGAGTTTAGAGGA

GGTTCTCAAGCAGGAACCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTGGTTCAATTGGATA

AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT

ATCAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A7T4M116

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.585	100	0.367

Detailed information NTG0516987