Detailed information NTG0516965

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: I6H78_RS05180
• Genome accession: NZ_CP066059
• Coordinates: 1069187..1071340 (-)
• Length: 717 a.a.
• NCBI ID: WP_198459010.1
• Uniprot ID: A0A7T4IR80
• Organism: Streptococcus oralis strain FDAARGOS_1021
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1064187..1076340

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H78_RS09455	-	1066804..1066872 (-)	69	Protein_1002	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
I6H78_RS05170 (I6H78_05170)	purC	1066949..1067656 (-)	708	WP_198459008.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
I6H78_RS05175 (I6H78_05175)	comB	1067825..1069174 (-)	1350	WP_198459009.1	competence pheromone export protein ComB	Regulator
I6H78_RS05180 (I6H78_05180)	comA	1069187..1071340 (-)	2154	WP_198459010.1	peptide cleavage/export ABC transporter ComA	Regulator
I6H78_RS05185 (I6H78_05185)	-	1071550..1071759 (-)	210	WP_000869801.1	hypothetical protein	-
I6H78_RS05190 (I6H78_05190)	-	1071784..1071972 (-)	189	WP_198459011.1	hypothetical protein	-
I6H78_RS05195 (I6H78_05195)	-	1071982..1072149 (-)	168	WP_000415691.1	bacteriocin	-
I6H78_RS05200 (I6H78_05200)	-	1072167..1072355 (-)	189	WP_084921541.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
I6H78_RS05205 (I6H78_05205)	-	1072799..1073035 (-)	237	WP_000136435.1	acyl carrier protein	-
I6H78_RS05210 (I6H78_05210)	plsX	1073042..1074034 (-)	993	WP_198459012.1	phosphate acyltransferase PlsX	-
I6H78_RS05215 (I6H78_05215)	recO	1074031..1074801 (-)	771	WP_198459013.1	DNA repair protein RecO	-
I6H78_RS05220 (I6H78_05220)	-	1074798..1075967 (-)	1170	WP_198459014.1	pyridoxal phosphate-dependent aminotransferase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80543.89 Da
• Isoelectric Point: 7.1568

>NTDB_id=516965 I6H78_RS05180 WP_198459010.1 1069187..1071340(-) (comA) [Streptococcus oralis strain FDAARGOS_1021]
MKFRKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVIGQDKKHIHIADPDPGVKLTKISRERFAQEWTGVSIFMAPSPGYKPHKEKKQGLLSFLPI
LFKQRGLVTNIVLATLLVTLINIVGSYYLQSIIDSYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLILGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTILIISLVLFSQNMTLFFISLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAQL
LLNVAVLWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSMM
KGDMIFKQVHYKYGYGRDVLSDINLTIPQGSKMAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGTHADLLAQNGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=516965 I6H78_RS05180 WP_198459010.1 1069187..1071340(-) (comA) [Streptococcus oralis strain FDAARGOS_1021]
ATGAAATTTAGGAAAAGGCACTATCGTCCCCAGGTGGATCAGATGGATTGTGGCGTGGCTTCTTTGGCTATGGTCTTTGG
TTACTACGGTAGTTATTACTCCTTGGCTCATCTACGAGAGTTAGCCAAGACGACCATGGATGGGACGACCGCTTTGGGAC
TTGTAAAGGTGGCAGAGGAGATTGGATTTGAGACGCGGGCTATCAAGGCGGATATGACGCTCTTTGATTTGCCAGATTTG
ACCTTTCCTTTTGTGGCTCATGTGCTCAAGGAAGGGAAGTTGCTCCACTACTATGTGGTGATAGGTCAGGATAAAAAGCA
CATTCATATCGCTGATCCGGATCCTGGTGTCAAGCTGACCAAGATTTCCCGTGAGCGTTTTGCGCAAGAGTGGACAGGGG
TCAGTATTTTTATGGCGCCATCTCCGGGCTATAAACCTCATAAGGAGAAGAAACAGGGTCTCCTATCCTTCTTGCCGATT
TTATTCAAACAGCGTGGCTTAGTTACCAATATCGTCCTAGCGACACTCTTGGTAACCTTGATCAATATCGTGGGCTCCTA
CTATCTTCAGTCCATCATTGATAGTTACGTGCCAGATCAGATGCGCTCGACGCTGGGTATTATCTCTATTGGGCTGGTCA
TCGTCTATATCCTCCAGCAGATTTTGTCCTACGCGCAGGAATATCTCCTACTAATCCTTGGGCAGCGCTTGTCCATCGAT
GTGATTTTGTCCTACATCAAGCATGTTTTTCACCTGCCGATGTCCTTTTTCGCGACACGCAGGACAGGAGAAATCGTATC
TCGTTTTACAGATGCCAACAGTATCATCGATGCGTTGGCGTCGACCATTCTGTCGATTTTCCTAGATGTGTCGACGATTT
TGATTATCTCGCTGGTCTTGTTTTCACAAAATATGACACTCTTTTTCATTAGTCTGCTTGCGCTTCCCATCTATACAGTG
ATTATCTTTGCCTTTATGAAGCCTTTTGAAAAGATGAATCGTGATACCATGGAAGCTAATGCGGTTCTGTCTTCTTCTAT
CATCGAGGACATCAACGGTATCGAGACCATTAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAGATTGATAAGGAAT
TTGTAGATTATCTGAAAAAATCCTTTACCTACAGTCGGGCAGAAAGTCAGCAAAAGGCACTGAAAAAAGTTGCTCAGCTC
CTGCTCAATGTTGCCGTTCTCTGGATGGGGGCAGTACTCGTCATGGATGGCAAGATGAGTTTGGGGCAATTGATTACCTA
TAATACTTTGCTTGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAACTTCAGACAGCGCAGGTTG
CCAATAATCGCTTAAATGAGGTTTATCTGGTCGCTTCGGAGTTTGAGGAGAAGAAAACAGTCGAAGATTTGAGCATGATG
AAGGGAGATATGATTTTTAAGCAGGTTCATTATAAGTATGGCTATGGTCGTGACGTCTTGTCGGATATCAATTTGACCAT
TCCGCAAGGATCAAAGATGGCTTTCGTGGGGATTTCAGGTTCGGGTAAGACCACCTTGGCAAAGATGATGGTTAATTTCT
ATGACCCTAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCTTGCGCCAGTATATC
AACTATCTACCTCAACAGCCCTATGTCTTTAACGGCACGATTTTGGAGAATCTGCTCCTTGGAGCCAAGGAAGGGACGAC
GCAAGAAGATATCTTACGAGCAGTTGAATTGGCTGAAATTCGGGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTAACTTCGGATGGGGCAGGGATTTCAGGTGGACAACGTCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCTGTCTTGATATTGGATGAGGCGACCAGCAGTCTGGATATTTTGACAGAGAAGCGGATCGTGGATAATCTCATGGCTTT
AGATAAGACCTTGATTTTCATCGCCCATCGCTTGACCATCGCTGAGCGGACAGAAAAGGTTGTTGTTTTGGATCAGGGCA
AAATTGTCGAAGAAGGTACCCATGCAGACTTGCTTGCACAGAATGGCTTTTACGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (500-650)

• ABC transporter transmembrane region (ABC_membrane) (169-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A7T4IR80

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	95.119	100	0.951
comA	Streptococcus pneumoniae Rx1	94.84	100	0.948
comA	Streptococcus pneumoniae D39	94.84	100	0.948
comA	Streptococcus pneumoniae R6	94.84	100	0.948
comA	Streptococcus mitis SK321	94.561	100	0.946
comA	Streptococcus pneumoniae TIGR4	94.421	100	0.944
comA	Streptococcus gordonii str. Challis substr. CH1	80.614	100	0.806
comA/nlmT	Streptococcus mutans UA159	64.993	100	0.65