NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	I6I32_RS01620	Genome accession	NZ_CP066041
Coordinates	326431..327105 (-)	Length	224 a.a.
NCBI ID	WP_000590630.1	Uniprot ID	A0A4V0BT06
Organism	Streptococcus oralis strain FDAARGOS_1075
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 321431..332105

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6I32_RS01595 (I6I32_01595)	-	321567..322496 (-)	930	WP_198464745.1	peptidase U32 family protein	-
I6I32_RS01600 (I6I32_01600)	-	322622..323302 (-)	681	WP_198464746.1	ABC transporter ATP-binding protein	-
I6I32_RS01605 (I6I32_01605)	-	323316..324371 (-)	1056	WP_198464747.1	ABC transporter permease	-
I6I32_RS01610 (I6I32_01610)	-	324755..325039 (+)	285	WP_071850864.1	DUF3270 domain-containing protein	-
I6I32_RS01615 (I6I32_01615)	ciaH	325104..326441 (-)	1338	WP_071850862.1	sensor histidine kinase	Regulator
I6I32_RS01620 (I6I32_01620)	ciaR	326431..327105 (-)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
I6I32_RS01625 (I6I32_01625)	-	327212..329758 (-)	2547	WP_198464748.1	M1 family metallopeptidase	-
I6I32_RS01630 (I6I32_01630)	-	329879..330319 (-)	441	WP_042768392.1	ASCH domain-containing protein	-
I6I32_RS01635 (I6I32_01635)	-	330316..331164 (-)	849	WP_042768391.1	putative PEP-binding protein	-
I6I32_RS01640 (I6I32_01640)	-	331142..331642 (-)	501	WP_042768390.1	NUDIX hydrolase	-
I6I32_RS01645 (I6I32_01645)	-	331653..332003 (-)	351	Protein_326	SDR family oxidoreductase	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25479.29 Da Isoelectric Point: 4.2660

                                >NTDB_id=516622 I6I32_RS01620 WP_000590630.1 326431..327105(-) (ciaR) [Streptococcus oralis strain FDAARGOS_1075]

MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

Download Length: 675 bp

                                >NTDB_id=516622 I6I32_RS01620 WP_000590630.1 326431..327105(-) (ciaR) [Streptococcus oralis strain FDAARGOS_1075]

ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGCCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT

CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGCGTCTATGACTTGATTTTGCTTGACCTGATGT

TGCCTGAAAAAAATGGTTTCCAAGTTCTGAAAGAATTGCGTGAAAAAGGAATCACGACACCAGTCCTTATCATGACTGCA

AAAGAGAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAGCCTTTCTACCTAGAAGA

ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAACACCTTGACCTATGGAGATATTGTCG

TCAACCTTTCAACGAATGAAGTGAAGGTGGAAGATACTCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAC

TTCCTTCAAAATCAAAATGTTATTCTTCCCAAGACGCAAATTTTTGACCGTCTATGGGGGTTTGATAGCGATACAACGAT

TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAGAATCTTCAAACCTTGC

GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae TIGR4	97.768	100	0.978
ciaR	Streptococcus pneumoniae D39	97.768	100	0.978
ciaR	Streptococcus pneumoniae R6	97.768	100	0.978
ciaR	Streptococcus pneumoniae Rx1	97.768	100	0.978
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366

Detailed information NTG0516622