Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   I6I32_RS01615 Genome accession   NZ_CP066041
Coordinates   325104..326441 (-) Length   445 a.a.
NCBI ID   WP_071850862.1    Uniprot ID   A0A1L8Q6I3
Organism   Streptococcus oralis strain FDAARGOS_1075     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 320104..331441
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6I32_RS01590 (I6I32_01590) rpiA 320742..321461 (-) 720 WP_198464744.1 ribose-5-phosphate isomerase RpiA -
  I6I32_RS01595 (I6I32_01595) - 321567..322496 (-) 930 WP_198464745.1 peptidase U32 family protein -
  I6I32_RS01600 (I6I32_01600) - 322622..323302 (-) 681 WP_198464746.1 ABC transporter ATP-binding protein -
  I6I32_RS01605 (I6I32_01605) - 323316..324371 (-) 1056 WP_198464747.1 ABC transporter permease -
  I6I32_RS01610 (I6I32_01610) - 324755..325039 (+) 285 WP_071850864.1 DUF3270 domain-containing protein -
  I6I32_RS01615 (I6I32_01615) ciaH 325104..326441 (-) 1338 WP_071850862.1 sensor histidine kinase Regulator
  I6I32_RS01620 (I6I32_01620) ciaR 326431..327105 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  I6I32_RS01625 (I6I32_01625) - 327212..329758 (-) 2547 WP_198464748.1 M1 family metallopeptidase -
  I6I32_RS01630 (I6I32_01630) - 329879..330319 (-) 441 WP_042768392.1 ASCH domain-containing protein -
  I6I32_RS01635 (I6I32_01635) - 330316..331164 (-) 849 WP_042768391.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50905.61 Da        Isoelectric Point: 9.5377

>NTDB_id=516621 I6I32_RS01615 WP_071850862.1 325104..326441(-) (ciaH) [Streptococcus oralis strain FDAARGOS_1075]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADANKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIAYENDRVFEYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVYATDRHLYLTVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=516621 I6I32_RS01615 WP_071850862.1 325104..326441(-) (ciaH) [Streptococcus oralis strain FDAARGOS_1075]
ATGTTCAATAAACTAAAAAAAACATGGTATGCAGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTTGATGAAAAACTCCAAGCCC
TTAGTAGCAGTCCCCAAGCGGTTATCCAGCTAGCCTTGAATCGGGCAACTGAAGAGGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAACAAGGCTGAAATCAAACCCAATGTTAGCTCAAATACAGAAGTTTTACTTTTTGACAAGGATTTTAACCA
ACTCTTATTAGGGAACCGTTTTTTAGGCTTGGATAAGATCAAGCTAGACAAAAAAGAGTTGAATCATATTCGGCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTACCGAATGATCTTGATGGAAACCAATTCTTCCTCCGTATCAAGCAAT
GTCAAATATGCGGCGGTTTTAATCAATACCAGCCAGCTCGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTATCTTTAATTGCCAGTGTTTACCTGGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCGAGTCACGAACTGAGAACACCTTTGGCCGTTTTACAAAATCGTTTAGAA
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCTAGCGAAAGCATTGCTTCTAGCCTCGAAGAAGTTCGCAACAT
GCGCTTTCTCACGACCAATCTTCTCAACCTTGCACGTCGCGATGATGGAATCAAACCAGAGATAGCAGAAGTTTCTCCAC
AATTCTTCAAAACAACCTTTGCCAACTATGAGTTGATTGCTTATGAAAATGATCGTGTTTTTGAGTATGAAAATCGAATT
TACCGTCCCTTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTGTTTGATAATGCTATCAAGTATACTGA
AGAAGATGGGAAAATTGAGTTTGTAGTCTATGCTACAGATCGCCACCTCTATCTTACAGTAACGGATAATGGAATTGGAA
TCTCAGCTGCTGACAAGAAGAAAATCTTTGACCGATTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCTTTAGCCAAGCAAATCGTAGATGCCTTACGAGGAACGATTAGCGTAAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAGATCGCTATTCAATCTCCTTCGAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1L8Q6I3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

54.795

98.427

0.539